Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions

Kinoshita, Eiichiro; Hayashi, Kyoko; Katayama, Hiroshi; Hayashi, Toshimitsu; Obata, Akio

doi:10.1271/bbb.120112

Cited by 70 publications

(62 citation statements)

References 25 publications

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“…Frequently reported in the literature is the antiviral activity of Sambucus nigra fruit. A very popular supplement with such properties that is sold as a prophylactic agent in many countries is the Sambucol preparation, patented in Israel by Dr. Madeleine Mumcuoglu (Kinoshita, Hayashi, Katayama, Hayashi, & Obata, 2012;Martens, 2008;Wierzbicki, 2002; Zakay-Rones, Thom, Wollan, & Wadstein, 2004). The healing properties of elderberry are mostly associated with the presence of phenolic compounds, which are characterized by a strong antioxidant activity and therefore are able to eliminate free radicals and counteract the oxidative stress, a factor causing the degradation of the human body, thus contributing to the development of a number of diseases (Gollucke, Peres, Odair, & Ribeiro, 2013).…”

Section: Medicinal Potentialmentioning

confidence: 99%

Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry

Młynarczyk

Walkowiak-Tomczak

Łysiak

2018

Journal of Functional Foods

189

149

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Section: Medicinal Potentialmentioning

confidence: 99%

Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry

Młynarczyk

Walkowiak-Tomczak

Łysiak

2018

Journal of Functional Foods

189

149

View full text Add to dashboard Cite

“…HA is also responsible for the virus' capacity to induce hemagglutination in human hosts (Ito et al, ; Mandenius et al, ), which Sambucol has been shown in vitro to inhibit fourfold to 16‐fold depending on the strain of influenza (Zakay‐Rones et al, ). Studies have also indicated that elderberry's effectiveness against infection may be due to immune stimulation (Kinoshita et al, ; Ho et al, ; Ho et al, ). In order to move toward the best possible treatment for influenza, more research is needed to determine to what extent S. nigra antiviral effects are due to each chemical constituent of the plant, and if synergistic effects exist between combinations of these constituents to increase their therapeutic potential.…”

Section: Antiviral Propertiesmentioning

confidence: 99%

“…One study on synergistic effects between amantadine and a multi‐herb treatment containing S. nigra flowers found that synergistic effects exists between the herbal treatment and several amantadine treatments against influenza in vitro (Serkedjieva and Zgorniak‐Nowosielska, ). A study comparing oseltamivir with concentrated elderberry juice in influenza‐infected mice found that the elderberry juice significantly inhibited the infection, and that while oseltamivir may have had slightly greater inhibition, elderberry worked at least in part by stimulating an immune response, while oseltamivir lessened immune response compared with a control group by directly inhibiting viral neuraminidase (Kinoshita et al, ). However, these few studies alone are insufficient to accurately determine the potential of S. nigra or its constituents in comparison with accepted antiviral medications, and more research is needed in this area.…”

Section: Recommendations For Usementioning

confidence: 99%

A Review of the Antiviral Properties of Black Elder (Sambucus nigraL.) Products

Porter

Bode

2017

Phytother. Res.

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Black elder (Sambucus nigra L.) has a long ethnobotanical history across many disparate cultures as a treatment for viral infection and is currently one of the most-used medicinal plants worldwide. Until recently, however, substantial scientific research concerning its antiviral properties has been lacking. Here, we evaluate the state of current scientific research concerning the use of elderberry extract and related products as antivirals, particularly in the treatment of influenza, as well as their safety and health impacts as dietary supplements. While the extent of black elder's antiviral effects are not well known, antiviral and antimicrobial properties have been demonstrated in these extracts, and the safety of black elder is reflected by the United States Food and Drug Administration approval as generally recognized as safe. A deficit of studies comparing these S. nigra products and standard antiviral medications makes informed and detailed recommendations for use of S. nigra extracts in medical applications currently impractical. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Investigations have also revealed the efficacy of S . nigra against infection that may be due to the stimulation of the immune system (Ho et al, ; Ho, Zou, Aslaksen, Wangensteen, & Barsett, ; Kinoshita, Hayashi, Katayama, Hayashi, & Obata, ). The literature showed a very high antiviral potential of S .…”

Section: Medicinal Plants Used In Influenzamentioning

confidence: 99%

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

Akram

Tahir

Shah

et al. 2018

Phytotherapy Research

213

170

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Viral infections are being managed therapeutically through available antiviral regimens with unsatisfactory clinical outcomes. The refractory viral infections resistant to available antiviral drugs are alarming threats and a serious health concern. For viral hepatitis, the interferon and vaccine therapies solely are not ultimate solutions due to recurrence of hepatitis C virus. Owing to the growing incidences of viral infections and especially of resistant viral strains, the available therapeutic modalities need to be improved, complemented with the discovery of novel antiviral agents to combat refractory viral infections. It is widely accepted that medicinal plant heritage is nature gifted, precious, and fueled with the valuable resources for treatment of metabolic and infectious disorders. The aims of this review are to assemble the facts and to conclude the therapeutic potential of medicinal plants in the eradication and management of various viral diseases such as influenza, human immunodeficiency virus (HIV), herpes simplex virus (HSV), hepatitis, and coxsackievirus infections, which have been proven in diverse clinical studies. The articles, published in the English language since 1982 to 2017, were included from Web of Science, Cochrane Library, AMED, CISCOM, EMBASE, MEDLINE, Scopus, and PubMed by using relevant keywords including plants possessing antiviral activity, the antiviral effects of plants, and plants used in viral disorders. The scientific literature mainly focusing on plant extracts and herbal products with therapeutic efficacies against experimental models of influenza, HIV, HSV, hepatitis, and coxsackievirus were included in the study. Pure compounds possessing antiviral activity were excluded, and plants possessing activity against viruses other than viruses in inclusion criteria were excluded. Hundreds of plant extracts with antiviral effect were recognized. However, the data from only 36 families investigated through in vitro and in vivo studies met the inclusion criteria of this review. The inferences from scientific literature review, focusing on potential therapeutic consequences of medicinal plants on experimental models of HIV, HSV, influenza, hepatitis, and coxsackievirus have ascertained the curative antiviral potential of plants. Fifty-four medicinal plants belonging to 36 different families having antiviral potential were documented. Out of 54 plants, 27 individually belong to particular plant families. On the basis of the work of several independent research groups, the therapeutic potential of medicinal plants against listed common viral diseases in the region has been proclaimed. In this context, the herbal formulations as alternative medicine may contribute to the eradication of complicated viral infection significantly. The current review consolidates the data of the various medicinal plants, those are Sambucus nigra, Caesalpinia pulcherrima, and Hypericum connatum, holding promising specific antiviral activities scientifically proven through studies on experimental animal mo...

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Anti-Influenza Virus Effects of Elderberry Juice and Its Fractions

Cited by 70 publications

References 25 publications

Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry

Bioactive properties of Sambucus nigra L. as a functional ingredient for food and pharmaceutical industry

A Review of the Antiviral Properties of Black Elder (Sambucus nigraL.) Products

Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review

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