Cystoid macular edema and anterior uveitis associated with latanoprost use

Warwar, Ronald E.; Bullock, John D.; Ballal, Deepti

doi:10.1016/s0161-6420(98)92977-3

Cited by 226 publications

(42 citation statements)

References 14 publications

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“…Arachidonic acid may, consequently, encourage the increase in eicosanoids as well as other proinflammatory mediators in the eye, thus causing an alteration in the blood-aqueous and blood-retina barrier [11, 13]. Clinically observable flare in the anterior chamber has been seen in some patients treated with latanoprost following anterior segment surgery [11, 13, 15, 17]. …”

Section: Discussionmentioning

confidence: 99%

“…In some cases, there is an increase in iris and eyelid pigmentation as well as an increase in growth and pigmentation of the eye lashes [7, 8]. Less frequently, keratitis [9, 10], anterior uveitis [11, 12]or cystoid macular edema [13, 14, 15, 16, 17]may appear. The onset of an intraocular inflammatory reaction following the use of these new molecules is a frequently debated possibility as it is strictly linked to the safe use of these drugs.…”

Section: Introductionmentioning

confidence: 99%

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Prostaglandin Analogs and Blood-Aqueous Barrier Integrity: A Flare Cell Meter Study

et al. 2004

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Purpose: To study, with an objective method, inflammation of the anterior segment of the glaucomatous eye after treatment with latanoprost, travoprost and bimatoprost. Materials and Methods: Sixty patients with chronic open-angle glaucoma aged between 38 and 76 years (mean 64.0 ± 12.2) were randomly assigned to latanoprost 0.005, travoprost 0.004 and bimatoprost 0.03%. The study period lasted 6 months. Intraocular pressure (IOP) was measured every 2 weeks. We studied the intraocular inflammation before and after 3 and 6 months of therapy with an instrument composed of a He-Ne laser beam system, a photomultiplier mounted on a slitlamp microscope and a computer. This flare meter allows objective determination of the flare and the number of cells in the aqueous of the anterior chamber. Results: At the baseline, IOP was 26.4 ± 3.6 mm Hg. After 3 months of treatment, mean IOP in the latanoprost group was 17.9 ± 0.3 mm Hg (p < 0.001) with a mean cellularity of 12.638 ± 3.284 photons/ms (p < 0.001). The travoprost group had an IOP of 17.2 ± 0.3 mm Hg (p < 0.001) with a cellularity of 9.719 ± 1.927 photons/ms (0.001). Finally, IOP in the bimatoprost group was 17.6 ± 0.5 mm Hg (p < 0.001) with a cellularity of 6.138 ± 1.475 photons/ms (p < 0.032). After 6 months of treatment, IOP in the latanoprost group was 18.1 ± 0.3 (p < 0.001), in the travoprost group 17.3 ± 0.3 (p < 0.001) and in the bimatoprost group 17.7 ± 0.5 mm Hg (p < 0.001), whereas cellularity was 11.838 ± 3.218 (p < 0.001), 8.950 ± 3.692 (p < 0.001) and 7.617 ± 2.603 photons/ms (p < 0.001), respectively. After 3 months, the travoprost (p < 0.013) and the bimatoprost groups (p < 0.001) had less flare compared with the latanoprost group and this remained so even at 6 months. When we compared the travoprost group with the bimatoprost group, we found significantly less flare at 3 months in the bimatoprost group (p < 0.001) but not at 6 months (p < 0.246). Conclusions: The flare meter analysis shows that the eyes treated with bimatoprost and travoprost have a less significantly broken blood-aqueous barrier and their anterior chamber is also significantly less inflamed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prostaglandin Analogs and Blood-Aqueous Barrier Integrity: A Flare Cell Meter Study

et al. 2004

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“…Some investigators have reported that latanoprost induced anterior uveitis or flare elevation in humans [9][10][11][12]: Fechtner et al [9], Warwar et al [10] and Smith et al [12] contributed case reports, whereas Miyake et al [11] described an experimental situation following cataract surgery. However, controlled clinical studies showed that inflammation was not associated with latanoprost in humans [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Linder et al [7] and Widergard et al [8] have reported that latanoprost had no clinically significant effect on the permeability of the blood-aqueous barrier in humans. Others have described anterior uveitis or disruption of the blood-aqueous barrier associated with latanoprost [9][10][11][12]. In the present study, we examined the effects of isopropyl unoprostone, latanoprost, and PGE 2 on aqueous flare elevation in pigmented rabbits.…”

mentioning

confidence: 94%

Effects of Isopropyl Unoprostone, Latanoprost, and Prostaglandin E<sub>2</sub> on Acute Rise of Aqueous Flare in Pigmented Rabbits

Zhang¹,

Hayasaka²,

Hayasaka³

et al. 2002

Ophthalmic Res

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Purpose: To evaluate the effect of isopropyl unoprostone, latanoprost, and prostaglandin E₂ (PGE₂) on aqueous flare elevation. Methods: Isopropyl unoprostone (0.12%) or latanoprost (0.005%) was topically instilled. Transcorneal diffusion of PGE₂, 25 µg/ml, using a glass cylinder, was achieved in pigmented rabbits. Aqueous flare was measured with a laser flare cell meter. Results: Topical instillation of isopropyl unoprostone induced aqueous flare elevation in rabbit eyes. Also, topical isopropyl unoprostone additionally induced aqueous flare elevation in eyes with transcorneal diffusion of PGE₂. Latanoprost did not induce flare elevation. Conclusion: Isopropyl unoprostone induced aqueous flare elevation in rabbits, and latanoprost did not produce aqueous flare elevation.

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“…It is very effective in lowering intraocular pressure and is usually well tolerated [2][3][4]. Among the very few side effects are itching and possibly anterior uveitis and cystoid edema [5,6], as well as reactivation of herpes simplex keratitis [7,8]. Various reports in the literature have also documented an increase in iris and eyelash pigmentation after several weeks of topical application [2,4,9].…”

Section: Introductionmentioning

confidence: 99%

Short-Time Application of Latanoprost Does Not Stimulate Melanogenesis in Bovine Ocular Melanin-Containing Cells in vitro

2001

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Topical use of latanoprost for glaucoma can lead to an increase in iris and eye lash pigmentation but the precise mechanism is unclear. To study the possible effect of this drug on ocular melanogenesis, we used cultures of bovine iris melanocytes, iris pigment epithelial cells, retinal pigment epithelial cells, and choroidal melanocytes. Latanoprost (at concentrations of 10^–8 and 10^–6 mol) was applied for 3 days, and cell numbers as well as melanin content were measured prior to and 10 days after exposure and compared to untreated controls. In none of the cell types examined a significant increase in melanin content or an increase in cell proliferation was observed. Additional treatment with the tyrosinase inhibitor α-methyl-p-tyrosine showed no significant effect either. Our results support the concept of a rather complex mechanism underlying the increased iris pigmentation after treatment with latanoprost.

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Cystoid macular edema and anterior uveitis associated with latanoprost use

Cited by 226 publications

References 14 publications

Prostaglandin Analogs and Blood-Aqueous Barrier Integrity: A Flare Cell Meter Study

Prostaglandin Analogs and Blood-Aqueous Barrier Integrity: A Flare Cell Meter Study

Effects of Isopropyl Unoprostone, Latanoprost, and Prostaglandin E<sub>2</sub> on Acute Rise of Aqueous Flare in Pigmented Rabbits

Short-Time Application of Latanoprost Does Not Stimulate Melanogenesis in Bovine Ocular Melanin-Containing Cells in vitro

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