Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas

Ayadi, Lobna; Toumi, Nabil; Frikha, F.; Daoud, E.; Makni, S.; Frikha, M.; Beyrouti, Mohamed Issam; Sellami‐Boudawara, Tahya

doi:10.1016/j.jpedsurg.2008.01.068

Cited by 19 publications

(18 citation statements)

References 11 publications

(22 reference statements)

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“…This cystic appearance may lead to misdiagnosis such as hydatid cyst or amebic abscess as in our case. In the literature there have been several case reports of UES of the liver being mistaken for hydatid disease (9,10,11). According to Buetow et al (7) the increased water content within the abundant myxoid stroma of UES accounts for the attenuation lower than that of soft tissue on CT scans and the high signal intensity on T2 weighted MRI, as was in our case (7).…”

supporting

confidence: 59%

Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: case report and review of the literature

Halefoğlu¹,

Öz²

2014

Journal of the Belgian Society of Radiology

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supporting

confidence: 59%

Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: case report and review of the literature

Halefoğlu¹,

Öz²

2014

Journal of the Belgian Society of Radiology

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“…In their literature review, Pachera et al found that the diagnosis of UES was delayed in 12 cases (23.5%) where the presentation with large cystic hepatic mass was suggestive of a benign lesion. There have been previous case reports of hepatic UES being mistaken for hydatid disease [5-8] however this is the first report of a case in which the diagnosis was made after attempted percutaneous drainage with evidence of rapid track-seeding and progression post-resection.…”

Section: Discussionmentioning

confidence: 89%

Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease

et al. 2010

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Primary undifferentiated embryonal sarcoma of the liver is a rare tumor with a peak incidence between the ages of 6 and 10 years. We report a case of a primary hepatic undifferentiated embryonal sarcoma arising in a 21-year-old male mistaken for hydatid disease of the liver. The rapid recurrence of this tumor along the site of attempted percutaneous drainage illustrates some important management points regarding this malignancy.

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“…Labs are often normal, although sometimes AFP, transaminase, or cancer antigen 125 will be elevated. Ultrasound displays a large solid lesion with cystic components, which frequently leads to misdiagnosis as a hydatid lesion, hepatic abscess, or a benign hepatic neoplasm [5][6][7]. CT is also often nonspecific and may show a hypodense mass with solid and cystic components [8].…”

Section: Discussionmentioning

confidence: 99%

Undifferentiated Embryonal Sarcoma of the Liver Presents as a Molecular Mimic of Parasitic Infection

Letherer

Mastenbrook

VanEnk

et al. 2020

Cureus

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Medical laboratory tests are becoming more reliable with increased specificity and sensitivity, leading to their use as definitive diagnostic tests for many medical conditions. Enzyme-linked immunosorbent assay (ELISA) tests are convenient, sensitive, and standardly used for rapid detection and quantification of antigens or patient antibodies against specific antigens. However, based upon the specificity and sensitivity of an ELISA test, the results may not be definitive for a specific disease but merely suggestive, due to potential cross-reactivity of antigens and antibodies. Here, we present a case of a 15-year-old male who presented with fever, nausea, and right upper quadrant pain. Computed tomography scan showed an 18-cm liver mass with cystic features. Biopsy results confirmed a diagnosis of undifferentiated embryonal sarcoma of the liver; however, the clinical picture was complicated by positive ELISA results for Echinococcus, Entamoeba histolytica, and histoplasmosis. Due to the absence of travel and positive ELISA result for three different infectious agents, we hypothesize that tumor molecular mimicry might have led to false-positive ELISA results in the absence of infection in this case, demonstrating a limitation of ELISA serology. Critical appraisal of all possible evidence to ensure alignment when assigning the final diagnosis is essential for optimal patient outcomes.

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Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas

Cited by 19 publications

References 11 publications

Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: case report and review of the literature

Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: case report and review of the literature

Primary undifferentiated embryonal sarcoma of the liver mistaken for hydatid disease

Undifferentiated Embryonal Sarcoma of the Liver Presents as a Molecular Mimic of Parasitic Infection

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