Cystic fluid chromogranin A levels in different pancreatic cystic lesions

Oruç, Nevin; Aydın, Ahmet; Barutçuoğlu, Burcu; Aktan, Çağdaş; Nart, Denız; Veral, Alı

doi:10.5152/tjg.2015.0329

Cited by 3 publications

(2 citation statements)

References 27 publications

(19 reference statements)

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“…Ascitis was diagnosed to be due to tubercular pathology as carcinoma with metastasis in CPN is very rare [5,6] her tumor markers were normal [7][8][9][10][11] she underwent spleen preserving distal pancreatectomy. Careful preoperative workup established that she had 2 being pathologies which could be cured.…”

Section: Discussionmentioning

confidence: 99%

Radical Resection HPB Tumors Presenting as Metastatic Lesions: Report of 2 Cases and Literature Review

Gupta¹

2017

RMES

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IntroductionCase 1 60 yr old lady referred to department of GI and HPB surgery for management for GB with ascetic, who underwent diagnostic laparoscopy for supposed to be metastatic ca GB at oncology hospital. Presenting features-Pain and distension abdomen, vomiting, generalized edema for 10 days. Diagnostic laparoscopy and biopsy findings of which were-diffuse ascitis with frozen subheptic region with GB not visualized, was biopsy negative for malignancy (exact site not mentioned). O/E-pt ASA GR3 pedal edema+, ascetic +, abdomen soft no s/o icterus/Lymphadenopathy/peritonitis /Mets Investigations-Hb-9.8gm/dl-, TLC-12700, DLC-N-74%, L-22%, E-2%, M-2%, urea-17 creatinine-0.6, HIV, HBS Ag, anti HCV -ve, serum bilirubin-0.3, SGOT-98, SGPT-78, ALP-327, alb -2.3 CXR-B/L pleural effusion, tapping done. USG-CBD normal, mass in GB lumen not involving liver, liver normal, moderate ascitis. Ascetic cytologyve CTSCAN -Mass in GB lumen localized to GB wall filling the lumen with no Mets /LNs, ascetic+ ca 19-9 -3u/ml. Management -She was treated for gastritis, hyponatremia, hypoprotinemia with PPIs, high protein diet, albumin infusion &TPN for 7 days. After nutritional build up reevaluation showed serum albumin-3.1gm/ dl, CECT findings same with resolution of ascitis. The ascitis was a result of hypoprotinemia as ascetic cytology was negative which disappeared after protein replacement. So decision was taken to proceed with diag. lap &radical cholecystectomy. Intraoperative Findings: Diag. lap-no free fluid, no Mets.Open: There was localized T2 tumor inside GB lumen no s/o hepatic infiltration, no Mets no HDL/Interaortocaval nodes. Radical ccx with segment 4b+5 resection with standard lymphadenectomy and port site excision done (pic1) HPE -gross-polypoid mass GB lumen with a stalk attached to body of GB (pic-2). MicroscopyPapillary adenocarcinoma GB (T2, N0 (0/10 ln), M0), no port site Mets. Postoperative coursePt remained stable oral diet started on day 1, she was discharged on day5. follow up-pt followed up for 2.5yrs every 3 Monika AbstractIntroduction: Pts with resettable tumors may have varied presentations. Few of the tumors can present like advanced tumors with metastasis. These cases should be properly assessed regarding lesions masquerading metastasis with having separate resettable pathology.

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Section: Discussionmentioning

confidence: 99%

Radical Resection HPB Tumors Presenting as Metastatic Lesions: Report of 2 Cases and Literature Review

Gupta¹

2017

RMES

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“…However, currently used markers do not allow a final diagnosis to be made, and new markers of CPNENs are being sought. In the study of Oruc et al cystic fluid levels of chromogranin A(CgA) (non-specific serum marker of neuroendocrine tumours) were not characteristic for CPNENs and did not have any value in the differential diagnosis of pancreatic cystic lesions [38].…”

Section: Differential Diagnosismentioning

confidence: 99%

Neuroendokrynne torbielowate nowotwory trzustki — punkt widzenia gastroenterologa

Dąbkowski

Kos–Kudła

Andrysiak‐Mamos

et al. 2018

Endokrynologia Polska

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Cystic pancreatic tumors are detected with increasing frequency and remain a clinical problem. Since they have different potential of malignancy the management and decision making process is a hard task. Guidelines, concerning pancreatic cystic tumors indicate the management with mucinous, serous cystic pancreatic neoplasms and solid pseudopappilary tumor, while the management with pancreatic cystic neuroendocrine tumors is not included into these standards. This review tries to answer the question are the cystic pancreatic neuroendocrine tumors different entity from solid tumors of neuroendocrine origin.The management and differential diagnosis of these neoplasms with special focus on features on imaging studies allowing preoperative diagnosis are discussed.

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