Chromogranin A and NSE in cystic pancreatic neuroendocrine tumors

Faias, Sandra; Prazeres, Susana; Cunha, Mário; Pereira, Luísa; Roque, Rúben; Chaves, Paula; Cravo, Marília; Claro, Isabel; Silveira, Margarida; Leite, Valeriano; Pereira, António Dias

doi:10.1016/j.clinre.2020.101601

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…This model is helpful to predict the GD2 phenotype in clinical specimens from cancer patients. NSE can be useful for the diagnosis, prognosis, staging, and treatment of related neuroendocrine tumors ( Faias et al, 2021 ). We found that our GTscore was positively correlated with NSE expression levels, indicating that the GTscore we developed could be used as a marker of neuroendocrine tumors.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Glycosyltransferase Signature for Predicting Prognosis and Immune Microenvironment in Neuroblastoma

Sha

Han

Sun

et al. 2022

Front. Cell Dev. Biol.

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Neuroblastoma (NB) is one of the most common solid tumors in children. Glycosyltransferases (GTs) play a crucial role in tumor development and immune escape and have been used as prognostic biomarkers in various tumors. However, the biological functions and prognostic significance of GTs in NB remain poorly understood. The expression data from Gene Expression Omnibus (GEO) and Therapeutically Applicable Research to Generate Effective Treatments (TARGET) were collected as training and testing data. Based on a progression status, differentially expressed GTs were identified. We constructed a GTscore through support vector machine, least absolute shrinkage and selection operator, and Cox regression in NB, which included four prognostic GTs and was an independent prognostic risk factor for NB. Patients in the high GTscore group had an older age, MYCN amplification, advanced International Neuroblastoma Staging System stage, and high risk. Samples with high GTscores revealed high disialoganglioside (GD2) and neuron-specific enolase expression levels. In addition, a lack of immune cell infiltration was observed in the high GTscore group. This GTscore was also associated with the expression of chemokines (CCL2, CXCL9, and CXCL10) and immune checkpoint genes (cytotoxic T-lymphocyte–associated protein 4, granzyme H, and granzyme K). A low GTscore was also linked to an enhanced response to anti–PD-1 immunotherapy in melanoma patients, and one type of tumor was also derived from neuroectodermal cells such as NB. In conclusion, the constructed GTscore revealed the relationship between GT expression and the NB outcome, GD2 phenotype, and immune infiltration and provided novel clues for the prediction of prognosis and immunotherapy response in NB.

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Section: Discussionmentioning

confidence: 99%

Identification of a Glycosyltransferase Signature for Predicting Prognosis and Immune Microenvironment in Neuroblastoma

Sha

Han

Sun

et al. 2022

Front. Cell Dev. Biol.

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“…Intra-cystic glucose measurement has yielded promising results in differentiating mucinous from nonmucinous cysts. In a multicentre study, a glucose concentration of ≤ 25 mg/dL had a sensitivity of 88.1% and a specificity of 91.2% in detecting mucinous pancreatic cysts [42] .…”

Section: Biochemical Markersmentioning

confidence: 97%

Recent advances in detecting premalignant pancreatic cysts

Jalal¹,

Gbadegesin²,

Ibrahim³

et al. 2023

J Cancer Metastasis Treat

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The incidental discovery of pancreatic cysts in asymptomatic patients is on the rise due to the widespread use of cross-sectional imaging. The challenge in the management of pancreatic cysts is in distinguishing those with malignant potentials, like mucinous pancreatic cysts, from non-mucinous cysts that have negligible malignant potentials. Similarly, it can be difficult to identify mucinous cysts that harbour high-grade dysplasia or early cancer. This review focuses on the recent advances in detecting pancreatic cancer and cysts with premalignant potential.

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Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker

Horvat,

Kos,

Pišlar

2024

Cell Biosci

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Enolase, a multifunctional protein with diverse isoforms, has generally been recognized for its primary roles in glycolysis and gluconeogenesis. The shift in isoform expression from α-enolase to neuron-specific γ-enolase extends beyond its enzymatic role. Enolase is essential for neuronal survival, differentiation, and the maturation of neurons and glial cells in the central nervous system. Neuron-specific γ-enolase is a critical biomarker for neurodegenerative pathologies and neurological conditions, not only indicating disease but also participating in nerve cell formation and neuroprotection and exhibiting neurotrophic-like properties. These properties are precisely regulated by cysteine peptidase cathepsin X and scaffold protein γ1-syntrophin. Our findings suggest that γ-enolase, specifically its C-terminal part, may offer neuroprotective benefits against neurotoxicity seen in Alzheimer's and Parkinson's disease. Furthermore, although the therapeutic potential of γ-enolase seems promising, the effectiveness of enolase inhibitors is under debate. This paper reviews the research on the roles of γ-enolase in the central nervous system, especially in pathophysiological events and the regulation of neurodegenerative diseases.

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Chromogranin A and NSE in cystic pancreatic neuroendocrine tumors

Cited by 5 publications

References 9 publications

Identification of a Glycosyltransferase Signature for Predicting Prognosis and Immune Microenvironment in Neuroblastoma

Identification of a Glycosyltransferase Signature for Predicting Prognosis and Immune Microenvironment in Neuroblastoma

Recent advances in detecting premalignant pancreatic cysts

Multifunctional roles of γ-enolase in the central nervous system: more than a neuronal marker

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