“…It is well known to work in synergy with ACh to regulate secretions (Lundberg et al, 1980; Heinz-Erian et al, 1985, 1986). Interestingly, VIP KO mice generated in the C57BL/6 background demonstrated, in vivo , the central role of VIP in CFTR regulation (Chappe and Said, 2012; Alcolado et al, 2014). Originally developed to study airway diseases, such as bronchial asthma (Hamidi et al, 2006; Szema et al, 2006; Said, 2009), VIP-KO mice were used by Alcolado et al (2014) to demonstrate the molecular link between VIP and CFTR regulation in the airways and small intestines, and observed a CF-like phenotype.…”