Cystic endometriosis of the epididymis

Giannarini, Gianluca; Scott, Cathryn Anne; Moro, U; Grossetti, Barbara; Pomara, Giorgio; Selli, Cesare

doi:10.1016/j.urology.2006.01.017

Cited by 31 publications

(26 citation statements)

References 12 publications

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“…17,18,20 Four of these cases also demonstrated peripheral smooth muscle, as in endomyometriosis, 14,17,18 and 3 reported confirmation of the patient's XY genotype through analysis of nonlesional tissue. 15,16,19 Here, we report a striking example of endomyometriosis in an XY male, with confirmatory immunohistochemical and molecular testing performed on the lesional tissue.…”

Section: Introductionmentioning

confidence: 55%

“…[11][12][13][14][15][16][17][18][19][20] This finding typically occurs in patients that underwent hormonal therapy for prostatic carcinoma, [11][12][13][14][15][16][17]20 though 2 reports were in males without such a history, including a 27-year-old. 19 Male endometriosis appears to originate exclusively in lower genitourinary tract locations, such as the urinary bladder, [11][12][13] prostate, 15 scrotum, 14 and paratesticular tissue. 17,18,20 Four of these cases also demonstrated peripheral smooth muscle, as in endomyometriosis, 14,17,18 and 3 reported confirmation of the patient's XY genotype through analysis of nonlesional tissue.…”

Section: Introductionmentioning

confidence: 99%

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Endomyometriosis (“Uterus - like mass”) in an XY Male

2014

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Male endometriosis and endomyometriosis (also termed "uterus-like mass") are 2 unusual manifestations of endometriosis. We report a case of male endomyometriosis with immunohistochemical and molecular confirmation. A 52-year-old man presented with stabbing pelvic pain. Computed tomography scan showed a mass in the right inguinal area, at the site of prior hernia repair. The lesion was tubular in shape, with a thick muscular wall and a central blood-filled lumen. Microscopically, the tissue showed layers of concentric smooth muscle, with endometrial glands and stroma lining the lumen. Many theories have been proposed regarding the etiology of both endomyometriosis and male endometriosis, including remnant rests of Müllerian tissue and metaplasia. Cases of male endometriosis typically have been linked to estrogen therapy for prostate cancer. Our patient had a history of cirrhosis and took spironolactone, possibly leading to an altered hormonal state that interacted with a reactive/metaplastic process at a site of prior surgery.

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Section: Introductionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Endomyometriosis (“Uterus - like mass”) in an XY Male

2014

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“…Benign pathological conditions such as the ectopic growth of endometrium in endometriosis and adenomyosis could be originating from the same ASC. This model could offer an explanation for clinical situations in which endometriosis is present in extra-pelvic sites (69), premenarche (70), and in men (71). Another clinical condition that can be easily understood by the role of ASC in the endometrium is the common observation (72) of endometrial regeneration following endometrial ablation, which is supposed to destroy the endometrium.…”

Section: Uterine Adult Stem Cellsmentioning

confidence: 99%

Multitasking Human Endometrium

Revel¹

2009

Obstetrical &Amp; Gynecological Survey

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“…Lastly, several cases of endometriosis lesions have been reported in elderly men who received high doses of estrogens for prostate cancer treatment, in whom the lesions appeared in the bladder and paratesticular region. 50,51 Higher levels of E 2 have been described in the menstrual blood of women with endometriosis compared to that of healthy women, suggesting that E 2 is locally formed in the endometrium of patients with endometriosis 52 (Figure 1). This is further confirmed by the aberrant expression of several enzymes of estrogen metabolism in the ectopic endometrium, which has high levels of aromatase and suppression of type 2 17, b-hydroxysteroid dehydrogenase.…”

Section: Estrogens and Endometriosismentioning

confidence: 99%

2-Methoxyestradiol in the Pathophysiology of Endometriosis: Focus on Angiogenesis and Therapeutic Potential

et al. 2012

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Endometriosis is a common condition among women of childbearing potential in which ectopic endometrial tissue is found outside the uterine cavity. Neoangiogenesis plays a major role in the development of endometriotic implants. Some evidence suggests that a disorder in the balance of proangiogenic and antiangiogenic factors that favors the former is induced by local hypoxia and is mediated by the hypoxia-inducible factor-vascular endothelium growth factor pathway could partially explain the development of this condition in some women. 2-methoxyestradiol is a biologically active metabolite of estradiol having antiangiogenic action. Changes in estradiol homeostasis have been locally observed in endometriosis. In this review, we summarize current knowledge of endometriosis pathophysiology, in particular, the balance between local 2-methoxyestradiol production and angiogenesis, which could promote the development of endometriotic lesions. 2-Methoxyestradiol emerges as a promising new candidate for the treatment of endometriosis.

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Cystic endometriosis of the epididymis

Cited by 31 publications

References 12 publications

Endomyometriosis (“Uterus - like mass”) in an XY Male

Endomyometriosis (“Uterus - like mass”) in an XY Male

Multitasking Human Endometrium

2-Methoxyestradiol in the Pathophysiology of Endometriosis: Focus on Angiogenesis and Therapeutic Potential

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