Endomyometriosis (“Uterus - like mass”) in an XY Male

González, Raúl; Shi, Chanjuan; Fadare, Oluwole

doi:10.1177/1066896913501385

Cited by 20 publications

(22 citation statements)

References 28 publications

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“…It is interesting that a man also had a ULM. [24] ULM can occur in various areas, there seems to be some elusive. The ovary is the most common site which followed by ligament of the uterus and ovary.…”

Section: Discussionmentioning

confidence: 99%

Uterus-like mass

Zhou³

2016

Medicine

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Background:Uterus-like mass (ULM) is an extremely rare lesion. Gross morphology of ULM resembling a uterus. It can occur in various organs in the abdominal cavity, even in the spinal cord. The histogenesis of ULM remains uncertain. A number of hypotheses have been proposed including metaplasia, congenital anomaly, and heterotopia theory.Methods:We describe a case of 43-year-old male presented with a complaint of acute low abdominal pain. Pelvic ultrasound found a large pelvic mass embedded in the broad ligament.Results:The mass contains a variable thickness smooth muscle layer lined with endometrial glands and stroma which resembling a uterus. Eventually, the patient was diagnosed as ULM by histopathological examination.Conclusion:Except hypomenorrhea, the patient did not have any other associated abnormalities. We suggest this case supports the metaplasia theory that ULM is a benign mass formed by the proliferation of ectopic endometrial stromal cells or pluripotent mesenchymal cells of the 2nd Müllerian system.

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Section: Discussionmentioning

confidence: 99%

Uterus-like mass

Zhou³

2016

Medicine

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“…3,9,10,13,15 Various theories have also been combined to understand the unusual types of endometriosis. Although its underlying cause is uncertain, it is likely to be multifactorial and include genetic factors with possible epigenetic influences, hormonal induction and apoptosis suppression.…”

Section: Makiyanmentioning

confidence: 99%

“…8 Male endometriosis of the prostate 9 and male "uterus-like mass" are 2 unusual manifestations of endometriosis. Gonz alez RS et al 10 reported a case of male uterus-like mass (endomyometriosis) in the right inguinal area at the site of a prior hernia repair. The lesion was tubular in shape, with a thick muscular wall and a central blood-filled lumen.…”

Section: Introductionmentioning

confidence: 99%

“…Microscopically, the tissue showed layers of concentric smooth muscle, with endometrial glands and stroma lining the lumen. 9,10 How explain the presence of endometriosis: in female fetuses, in females with complete utero-vaginal aplasia without functional endometrial cavity and even in males or DSD (disorders of sex development) patients with 46,XY karyotype?…”

Section: Introductionmentioning

confidence: 99%

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Endometriosis origin from primordial germ cells

Makiyan

2017

Organogenesis

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ABSTRACT. Endometriosis is defined by the presence of endometrial ectopia. Multiple hypotheses have been postulated to explain the etiology of endometriosis to understand various clinical evidences. The etiology of endometriosis is still unclear.The primary question to understanding the etiology of endometrial ectopia (endometriosis) is determining the origin of eutopic (normally cited) endometrium.According to the new theory, primordial germ cells migrate from hypoblast (yolk sac close to the allantois) to the gonadal ridges. The gonadal ridges which composed of primordial germ cells derive to the: eutopic endometrium, ovary, ovarian ligament and ligamentum teres uteri.There are 2 principal processes in uterine organogenesis: the intersection of gonadal ridges with mesonephral ducts to form the uterine folds with an endometrial cavity and the fusion of the both uterine folds together to form the unicavital (normal) uterus. In the uterine folds there are closer cell-to-cell communications, polypotential germ cells differentiate and grow into myometrium and endometrial layers.Some of the polypotential germ cells fail to reach the ridges and stay in the peritoneal cavity, where they may be transforming into external endometrial heterotopies.The main insight in the etiology of endometriosis is polypotential germ cells origin, which may explain its potency, pathogenesis and expansion.

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“…However, the presence of bundles of smooth muscle in the stroma of the lesion, as was observed in this case, is unusual. This feature makes the lesion more of a uterus-like mass or endomiometrioma [ 44 ].…”

Section: Case Presentationmentioning

confidence: 99%

A rare case of endometrioma in a bitch

et al. 2015

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BackgroundEndometriosis is ectopic development of endometrial glands and stroma in extra-uterine sites and if the lesions occur as a well-defined mass is referred to as endometrioma. In the literature, endometrioma has been reported in only women and there are no reports of endometrioma in animals, including non-human primates.Case presentationA rare case of endometrioma is reported in an 11-year-old female German Shepherd with clinical signs of dehydration, anemia and prostration. Necropsy revealed ascites, generalized pallor, and a well-demarcated reddish mass adjacent to the left ovary and uterus and adherent to the retroperitoneum. The mass measured 25.0 × 20.0 cm with intermingled soft and firm areas. Upon incision, the mass was found to be solid with variable sized cystic cavities filled with coagulated blood. Microscopically, the mass was composed of cuboidal or prismatic epithelial cells arranged in tubules or acini. The epithelium of the mass had similar characteristics to the normal endometrium with PAS-positive secretions. The stroma was prominent and formed by loose connective tissue and smooth muscle fibers as confirmed by Masson trichrome. Extensive multifocal areas of hemorrhage were also observed in the stroma of the mass and in the interior of some epithelium-lined, cystic structures. Most of the epithelial cells had strong and diffuse cytokeratin expression, and some had vimentin expression. Epithelial and stromal cells also showed ERβ, AR, VEGF and COX2 expression. The stroma showed areas with strong and diffuse vimentin expression. Factor VIII expression was observed only in the endothelium of blood vessels in the stroma.ConclusionsThe macroscopic, microscopic and immunohistochemical findings are consistent with an endometrioma.

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Endomyometriosis (“Uterus - like mass”) in an XY Male

Cited by 20 publications

References 28 publications

Uterus-like mass

Uterus-like mass

Endometriosis origin from primordial germ cells

A rare case of endometrioma in a bitch

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