Cystic disease of the breast: Relationship to carcinoma

Davis, Herbert H.; Simons, Milton; Davis, John B.

doi:10.1002/1097-0142(196408)17:8<957::aid-cncr2820170802>3.0.co;2-o

Cited by 200 publications

(43 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is quite possible that multiple monoclonal AH lesions could arise in a single subject, few, if any, of which ever accumulate the additional genetic abnormalities required to progress to a malignancy. This scenario suggests that a field defect might exist in certain breasts, a hypothesis consistent with the bilateral risk of cancer in patients diagnosed with AH lesions (1,3,17,22,23). Alternative models of breast tumorigenesis exist, and some breast tumors may not evolve through an identifiable proliferative stage.…”

Section: Discussionmentioning

confidence: 65%

See 1 more Smart Citation

Detection of monoclonal microsatellite alterations in atypical breast hyperplasia.

Rosenberg

Morenas²,

Huang³

et al. 1996

J. Clin. Invest.

View full text Add to dashboard Cite

Atypical hyperplastic (AH) breast lesions are currently classified and treated as benign proliferative disorders, but their presence is associated with a four-to fivefold increased risk of developing breast cancer. Currently, it is not known if an AH lesion is a marker of increased risk, or is itself a premalignant lesion. To investigate this question, we used a series of 15 microsatellite loci to analyze 15 separate AH lesions microdissected from the archived pathology specimens of subjects with no coincident or previous breast malignancy. We found that a significant subset (6/15, or 40%) of these AH lesions demonstrated evidence of monoclonal microsatellite alterations, both length variation and allele loss. These monoclonal alterations suggest that the AH lesion has already undergone genetic changes conferring a growth advantage. Thus, these AH lesions may actually be early neoplasms. We also noted that monoclonality characterized AH lesions in younger as compared with older women (44 vs. 59 yrs, P Ͻ 0.05) and that a subset of monoclonal lesions (4/6) demonstrated microsatellite alterations at more than one locus, suggesting that an undetermined type of genetic instability may play a role early in the development of abnormal breast proliferations. These findings contribute to our un-

show abstract

Section: Discussionmentioning

confidence: 65%

“…The risk appears to affect both breasts (1,3,17,22,23), and may be greatest within 10 yr of diagnosis (31) and in premenopausal women (2,4). At present, no reliable pathologic characteristics can identify which subjects with AH lesions will, and which will not, develop a malignancy.…”

Section: Discussionmentioning

confidence: 99%

Detection of monoclonal microsatellite alterations in atypical breast hyperplasia.

Rosenberg

Morenas²,

Huang³

et al. 1996

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…Increases in the enzymes in the tumor tissue ranged from 1.4-fold for the fl-N-acetylglucosaminidase activity to 5-fold for the neuraminidase activity. In five patients with fibrocystic disease, which is considered by many (19) to be a premalignant lesion of the human female breast, intermediate levels of some of the degradative enzymes were found (Table 4). Moreover, in fibroadenoma, a noninvasive nonmalignant tumor, enzyme levels were in general normal or slightly elevated.…”

Section: Resultsmentioning

confidence: 99%

Enzyme Activity in Invasive Tumors of Human Breast and Colon

Bosmann

Hall

1974

Proc. Natl. Acad. Sci. U.S.A.

172

View full text Add to dashboard Cite

show abstract

“…incidence of gross cysts on histology was 23% and postmortem studies suggest an even higher incidence (Davies et al, 1964) yet it is estimated that only 7% of women in the Western world will develop a clinically aspirable breast cyst in their lifetime (Haagensen, 1971). No information is available on the clinical cyst aspiration rate in the Page and Dupont paper.…”

Section: Discussionmentioning

confidence: 99%

“…No information is available on the clinical cyst aspiration rate in the Page and Dupont paper. Modern practice is to aspirate breast cysts and histology is rarely available in contrast to the older series (Page et al, 1978;Dupont & Page, 1985;Davies et al, 1964) and thus direct comparison between studies is difficult. Haagensen's original finding of an increased breast cancer risk in women who have had aspiration of a breast cyst has been sustained in this study.…”

Section: Discussionmentioning

confidence: 99%