Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea

Tsaoussoglou, Marina; Lianou, Loukia; Maragozidis, Panagiotis; Hatzinikolaou, Souzana; Mavromati, Maria; Orologas, N; Panaghiotopoulou-Gartagani, Polytimi; Rassidakis, George Z.; Balatsos, Nikolaos A. A.; Chrousos, George P.; Kaditis, Athanasios G.

doi:10.1016/j.sleep.2012.03.010

Cited by 36 publications

(34 citation statements)

References 19 publications

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“…Recently, researchers have been studying the role of leukotrienes in the pathophysiology of adenotonsillar hypertrophy and OSA. Increased expression of leukotriene receptors have now been identified in the tonsillar tissue of children with OSA [13]. Thus, researchers have begun to investigate the role of montelukast, a leukotriene inhibitor, in the treatment of pediatric OSA [14].…”

Section: Montelukast (Oral)mentioning

confidence: 99%

An Update on the Management of Pediatric Obstructive Sleep Apnea

Rubinstein

Baldassari

2015

Curr Treat Options Peds

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Section: Montelukast (Oral)mentioning

confidence: 99%

An Update on the Management of Pediatric Obstructive Sleep Apnea

Rubinstein

Baldassari

2015

Curr Treat Options Peds

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“…Immunofluorescence was performed with the same anti-CD3, CD4, CD45, FoxP3, and GATA3 antibodies, and then incubated in for 30 min in fluorescence secondary antibodies as described previously44. Sections were observed under a fluorescence microscope (×200 magnification).…”

Section: Methodsmentioning

confidence: 99%

The relationship between allergic status and adenotonsillar regrowth: a retrospective research on children after adenotonsillectomy

Huo

Shi

Shu

et al. 2017

Sci Rep

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Adenotonsillar regrowth in children after adenotonsillectomy (T&A) for obstructive sleep apnea (OSA) is often seen in clinical treatment, however, the relationship between allergic disease and adenotonsillar regrowth remains unclear. In this retrospective study, children were assigned to either the recurrence or control group, and subdivided by age at operation. Among children over 36 months, those in the recurrence group had more allergic disease and higher IgE, IL-4, and IL-5 levels than the same-aged children in control group. The Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) scores for nasal symptoms and activity were higher in children older than 36 months in recurrence group. The results of immunohistochemistry and immunofluorescence showed that FoxP3+ cells (Tregs) were less, while GATA3+ cells (Th2 cells) were more in recurrence group for all ages. Allergic status and low levels of FoxP3 were proved as independent risk factors for adenotonsillar regrowth by multivariate logistic regression. These results indicate that allergic disease is a risk factor for adenotonsillar regrowth in children following T&A for OSA, and this risk increases with age. The decreased level of Tregs and subsequent changes in immune function play an important role in the pathogenesis of adenotonsillar regrowth.

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“…Accordingly, alterations in local (i.e., upper airway) and systemic inflammatory markers have been consistently reported in children with OSA (Li et al, 2007; Gozal et al,2008; Goldbart et al,2006; Kaditis et al, 2009; Shen et al, 2011), thereby suggesting that inflammation is an important precipitating risk factor for OSA. For example, increased expression of cysteinyl leukotrienes and changes in glucocorticoid receptor expression and activity have been reported by several investigators in the adenoids and tonsils of children with OSA, and putatively assigned a mechanistic role in the induction of hyperplasia and hypertrophy of these upper airway tissues (Goldbart et al, 2004; Kaditis et al,2008; Goldbart et al, 2005; Tsaoussoglou et al, 2012). …”

Section: Pathophysiological Mechanisms In Psdbmentioning

confidence: 98%

Genotype–phenotype interactions in pediatric obstructive sleep apnea

Kheirandish‐Gozal¹,

Gozal²

2013

Respiratory Physiology & Neurobiology

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Pediatric sleep disordered breathing (PSDB) is not only a very frequent condition affecting 2–4% of all children, but is also associated with an increased risk for a variety of manifestations underlying end-organ injury and dysfunction that impose both immediate and potentially long-term morbidities and corresponding inherent elevations in healthcare costs. One of the major problems with the creation of valid algorithms aiming to stratify diagnostic and treatment prioritization lies in our current inability to predict and identify those children who are most at-risk for PSDB-induced adverse consequences. Thus, improved our understanding of the mechanisms governing phenotype variance in PSDB is essential. Here, we examine some of the potential underpinnings of phenotypic variability in PSDB, and further propose a conceptual framework aimed at facilitating the process of advancing knowledge in this frequent disorder.

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Cysteinyl leukotriene receptors in tonsillar B- and T-lymphocytes from children with obstructive sleep apnea

Cited by 36 publications

References 19 publications

An Update on the Management of Pediatric Obstructive Sleep Apnea

An Update on the Management of Pediatric Obstructive Sleep Apnea

The relationship between allergic status and adenotonsillar regrowth: a retrospective research on children after adenotonsillectomy

Genotype–phenotype interactions in pediatric obstructive sleep apnea

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