Genotype–phenotype interactions in pediatric obstructive sleep apnea

Kheirandish‐Gozal, Leila; Gozal, David

doi:10.1016/j.resp.2013.03.016

Cited by 53 publications

(24 citation statements)

References 79 publications

(78 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings also indicate the need to develop effective tools that will enable objective and accurate prediction of the response to treatment of obese children with OSAS [41][42][43][44][45], and the identification of those at risk for developing OSAS with end-organ damage.…”

Section: Discussionmentioning

confidence: 99%

Treatment outcomes of obstructive sleep apnoea in obese community-dwelling children: the NANOS study

et al. 2015

Self Cite

View full text Add to dashboard Cite

The first line of treatment of obstructive sleep apnoea syndrome (OSAS) in children consists of adenotonsillectomy (T&A). The aim of the present study was to evaluate treatment outcomes of OSAS among obese children recruited from the community.A cross-sectional, prospective, multicentre study of Spanish obese children aged 3-14 years, with four groups available for follow-up: group 1: non-OSAS with no treatment; group 2: dietary treatment; group 3: surgical treatment; and group 4: continuous positive airway pressure treatment.117 obese children (60 boys, 57 girls) with a mean age of 11.3±2.9 years completed the initial (T0) and follow-up (T1) assessments. Their mean body mass index (BMI) at T1 was 27.6±4.7 kg·m −2 , corresponding to a BMI Z-score of 1.34±0.59. Mean respiratory disturbance index (RDI) at follow-up was 3.3±3.9 events·h −1 . Among group 1 children, 21.2% had an RDI ⩾3 events·h −1 at T1, the latter being present in 50% of group 2, and 43.5% in group 3. In the binary logistic regression model, age emerged as a significant risk factor for residual OSAS (odds ratio 1.49, 95% confidence interval 1.01-2.23; p<0.05) in obese children surgically treated, and RDI at T0 as well as an increase in BMI emerged as significant risk factors for persistent OSAS in obese children with dietary treatment (OR 1.82,).Age, RDI at diagnosis and obesity are risk factors for relatively unfavourable OSAS treatment outcomes at follow-up. @ERSpublications Age, RDI and obesity are risk factors for unfavourable OSAS treatment outcomes at follow-up

show abstract

Section: Discussionmentioning

confidence: 99%

Treatment outcomes of obstructive sleep apnoea in obese community-dwelling children: the NANOS study

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is therefore plausible that susceptibility modifiers, both genetic and environmental, may play a role in phenotypic expression 43. Accordingly, several genetic factors have been thus far been identified to account for discrepancies in the cognitive functional performance of children with OSA.…”

Section: Morbidity Of Osamentioning

confidence: 99%

Obstructive sleep apnea in children: a critical update

Tan¹,

Gozal²,

Kheirandish‐Gozal³

2013

NSS

Self Cite

105

View full text Add to dashboard Cite

Obstructive sleep apnea (OSA) in children is a highly prevalent disorder caused by a conglomeration of complex pathophysiological processes, leading to recurrent upper airway dysfunction during sleep. The clinical relevance of OSA resides in its association with significant morbidities that affect the cardiovascular, neurocognitive, and metabolic systems. The American Academy of Pediatrics recently reiterated its recommendations that children with symptoms and signs suggestive of OSA should be investigated with polysomnography (PSG), and treated accordingly. However, treatment decisions should not only be guided by PSG results, but should also integrate the magnitude of symptoms and the presence or absence of risk factors and signs of OSA morbidity. The first-line therapy in children with adenotonsillar hypertrophy is adenotonsillectomy, although there is increasing evidence that medical therapy, in the form of intranasal steroids or montelukast, may be considered in mild OSA. In this review, we delineate the major concepts regarding the pathophysiology of OSA, its morbidity, diagnosis, and treatment.

show abstract

“…Adenotonsillectomy is the most effective method in treating OSAS; however, anti-inflammatory treatments such as leukotriene receptor antagonists or nasal steroids may be useful in the residual OSAS after adenotonsillectomy (25,26).…”

Section: Discussionmentioning

confidence: 99%

Adenoid Vegetation in Children with Allergic Rhinitis

Bozkurt¹,

Dizdar²,

Korkut³

et al. 2016

Turk Arch Otorhinolaryngol

View full text Add to dashboard Cite

Objective: Pediatric patients with nasal obstruction due to adenoid vegetation (AV) can also encounter allergic rhinitis (AR) as a comorbidity. The aim of the study was to estimate the incidence of mite sensitization and its effect on adenoid size in children who underwent adenoidectomy.Methods: This prospective randomized study conducted between August and September 2014 included 84 children. Skin Prick Test (SPT) for inhalant allergens was preoperatively applied to all children who underwent adenoidectomy for nasal obstruction. Children were divided into two study groups: AV only (Group I) (n=52) and AV with Dermatophagoides Pteronyssinus and/or D. farinae allergy (Group II) (n=32). Postoperative specimen volumes, visual analogue scale (VAS) scores, and adenoid volumes measured using flexible fiberoptic nasopharyngolaryngoscopy were compared between the two groups.Results: Postoperative specimen volume measures were higher in Group II compared with those in Group I (p<0.05). Furthermore, in preoperative endoscopic examination, adenoid volume measures were higher in Group II compared with those in Group I (p<0.05). Pre and postoperative VAS scores in SPT+ group were higher in the Group II (p<0.05) than those in Group I. Conclusion:We observed that children with AR tend to have an early onset of symptoms of adenoid hypertrophy. We believe that focusing on the management of role of allergy regarding these early symptoms will reduce the need for surgery in a large number of cases. We suggest that SPT must be performed in all children with AV and adenoid examination should not be neglected in children with AR. Keywords: Adenoid vegetation, allergic rhinitis, adenoid volume

show abstract

Genotype–phenotype interactions in pediatric obstructive sleep apnea

Cited by 53 publications

References 79 publications

Treatment outcomes of obstructive sleep apnoea in obese community-dwelling children: the NANOS study

Treatment outcomes of obstructive sleep apnoea in obese community-dwelling children: the NANOS study

Obstructive sleep apnea in children: a critical update

Adenoid Vegetation in Children with Allergic Rhinitis

Contact Info

Product

Resources

About