Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

Chen, Min; Zhu, Jieying; Mu, Wang-Jing; Guo, Liang

doi:10.1016/j.gendis.2021.12.023

Cited by 26 publications

(25 citation statements)

References 111 publications

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“…In diverse human cancers, cysteine oxidation shifts toward enhancing adaptation of cancerous cells to reduce oxidative stress through increase of their antioxidative capacity (Chen et al, 2022). CDO1 catalyzes the rate limiting step in cysteine oxidation and is frequently downregulated by promoter methylation in many cancers (Brait et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

The Origin of Cysteine and its Catabolism in Mammalian Tissues and Tumors

Yoon

Combs

Falzone

et al. 2022

Preprint

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Cysteine plays critical roles in cellular biosynthesis, enzyme catalysis, and is an essential contributor to redox metabolism. While cultured cells are highly dependent on exogenous cystine for proliferation and survival, how diverse tissues obtain and use cysteine in vivo has not been characterized. We comprehensively interrogated cysteine metabolism in normal murine tissues and the cancer that arise from them using stable isotope 13C-serine and 13C-cystine tracing. We found that de novo cysteine synthesis was highest in normal liver and pancreas and absent in lung tissue. In tumors, cysteine synthesis was either inactive or downregulated during tumorigenesis. By contrast, cystine uptake and metabolism to downstream metabolites was a universal feature of normal tissues and tumors. Differences in cysteine catabolism were evident across tumor types, including glutathione synthesis. Thus, cystine is a major contributor to the cysteine pool in tumors and cysteine catabolic pathways are differentially active across tumor types.

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Section: Resultsmentioning

confidence: 99%

The Origin of Cysteine and its Catabolism in Mammalian Tissues and Tumors

Yoon

Combs

Falzone

et al. 2022

Preprint

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“…All these proteins are known to facilitate the occurrence of ferroptosis. C-Myc regulates cysteine dioxygenase type 1 (CDO1) [ 69 ], the inhibition of which restores the activity of GPx4 [ 70 ]. Anti-apoptotic protein HSP-70 is involved in rendering resistance to multiple types of regulated cell death [ 71 , 72 ] and was shown to sustain damage from increased levels of ROS and lipid peroxides [ 73 ].…”

Section: Gallium Salts Complexes and Nanoparticlesmentioning

confidence: 99%

Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings

Bartos

Sikora

2023

IJMS

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Ferroptosis was first reported as a separate modality of regulated cell death in 2008 and distinguished under its current name in 2012 after it was first induced with erastin. In the following decade, multiple other chemical agents were researched for their pro- or anti-ferroptotic properties. Complex organic structures with numerous aromatic moieties make up the majority of this list. This review fills a more overlooked niche by gathering, outlining and setting out conclusions regarding less prominent cases of ferroptosis induced by bioinorganic compounds and reported on within the last few years. The article contains a short summary of the application of bioinorganic chemicals based on gallium, several chalcogens, transition metals and elements known as human toxicants used for the purpose of evoking ferroptotic cell death in vitro or in vivo. These are used in the form of free ions, salts, chelates, gaseous and solid oxides or nanoparticles. Knowledge of how exactly these modulators promote or inhibit ferroptosis could be beneficial in the context of future therapies aimed against cancer or neurodegenerative diseases, respectively.

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“…Adipocyte differentiation is a finely regulated process. PPARγ and C/EBPα are the key adipogenic factors (Chen et al, 2022). In the meantime, a variety of negative regulators for adipogenesis has been reported, such as Pref‐1, Wnt family proteins, Krueppel‐like factor (KLF) 2/3, GATA2/3, and so on (Guo et al, 2019).…”

Section: Overview Of Adipocyte Differentiationmentioning

confidence: 99%

Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism

Yan

Guo

2023

Journal Cellular Physiology

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White adipocytes play a key role in the regulation of fat mass amount and energy balance. An appropriate level of white adipocyte differentiation is important for maintaining metabolic homeostasis. Exercise, an important way to improve metabolic health, can regulate white adipocyte differentiation. In this review, the effect of exercise on the differentiation of white adipocytes is summarized. Exercise could regulate adipocyte differentiation in multiple ways, such as exerkines, metabolites, microRNAs, and so on. The potential mechanism underlying the role of exercise in adipocyte differentiation is also reviewed and discussed. In‐depth investigation of the role and mechanism of exercise in white adipocyte differentiation would provide new insights into exercise‐mediated improvement of metabolism and facilitate the application of exercise‐based strategy against obesity.

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Cysteine dioxygenase type 1 (CDO1): Its functional role in physiological and pathophysiological processes

Cited by 26 publications

References 111 publications

The Origin of Cysteine and its Catabolism in Mammalian Tissues and Tumors

The Origin of Cysteine and its Catabolism in Mammalian Tissues and Tumors

Bioinorganic Modulators of Ferroptosis: A Review of Recent Findings

Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism

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