Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism

Abstract

White adipocytes play a key role in the regulation of fat mass amount and energy balance. An appropriate level of white adipocyte differentiation is important for maintaining metabolic homeostasis. Exercise, an important way to improve metabolic health, can regulate white adipocyte differentiation. In this review, the effect of exercise on the differentiation of white adipocytes is summarized. Exercise could regulate adipocyte differentiation in multiple ways, such as exerkines, metabolites, microRNAs, and so on. The potential mechanism underlying the role of exercise in adipocyte differentiation is also reviewed and discussed. In‐depth investigation of the role and mechanism of exercise in white adipocyte differentiation would provide new insights into exercise‐mediated improvement of metabolism and facilitate the application of exercise‐based strategy against obesity.

Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice

“…NAFLD is a primary metabolic disease state with an increasing prevalence rate but can be prevented with regular exercise 8 , 9 , 16 , 17 . Exercise has a powerful effect in the prevention and treatment of NAFLD, and it is even proved to be more effective than some low-performing pharmacological agents 18 – 21 .…”