Cysteine: A multifaceted amino acid involved in signaling, plant resistance and antifungal development

Roblin, Gabriel; Octave, Stéphane; Faucher, Mireille; Fleurat‐Lessard, Pierrette; Berjeaud, Jean‐Marc

doi:10.1016/j.plaphy.2018.05.024

Cited by 19 publications

(9 citation statements)

References 77 publications

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“…Cysteine, an important amino acid implicated in plant sulfur assimilation, is crucial in resistance against pathogens, among other vital pathways. Roblin et al (77) verified the cysteine capacity of inhibiting completely or partially the growth of some fungal pathogens (Phaeomoniella chlamydospora and Phaeoacremonium minimum), affecting both spore germination and mycelium development. This could be tested and applied to control wood-degrading diseases.…”

Section: Thiols and Derivativesmentioning

confidence: 99%

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Redondo-Blanco

Fernández

López-Ibáñez

et al. 2020

Journal of Food Protection

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Synthetic food additives generate a negative perception in consumers. This fact generates an important pressure on food manufacturers, searching for safer natural alternatives. Phytochemicals (such as polyphenols and thiols) and plant essential oils (terpenoids) possess antimicrobial activities that are able to prevent food spoilage due to fungi (e.g., Aspergillus, Penicillium) and intoxications (due to mycotoxins), both of which are important economic and health problems worldwide. This review summarizes industrially interesting antifungal bioactivities from the three main types of plant nutraceuticals: terpenoids (as thymol), polyphenols (as resveratrol) and thiols (as allicin) as well as some of the mechanisms of action. These phytochemicals are widely distributed in fruits and vegetables and are very useful in food preservation as they inhibit growth of important spoilage and pathogenic fungi, affecting especially mycelial growth and germination. Terpenoids and essential oils are the most abundant group of secondary metabolites found in plant extracts, especially in common aromatic plants, but polyphenols are a more remarkable group of bioactive compounds as they show a broad array of bioactivities. HIGHLIGHTS

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Section: Thiols and Derivativesmentioning

confidence: 99%

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Redondo-Blanco

Fernández

López-Ibáñez

et al. 2020

Journal of Food Protection

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“…To the best of the authors' knowledge, no data on the role of tyrosine on GTDs has been published to date. Nonetheless, cysteine has been reported to be involved in signaling, plant resistance and antifungal development [27]. Like other amino acids, cysteine can be transported along the vascular tissues of vines over long distances, and it can induce dramatic alterations in the structural organization of the mycelium (nucleus, mitochondria, vacuoles and cell wall), causing the death of the hyphae [52].…”

Section: Mechanism Of Actionmentioning

confidence: 99%

“…), and is associated with high resistance rates to both bio-and necrotrophic phytopathogens. In a recent study by Roblin, et al [27], it was reported that cysteine may be able to control fungal diseases either by acting directly on fungal development and/or functioning as an early signal that elicits the plant's host reaction. In relation to GTDs, the same group also chose cysteine as a one of the chemicals in their experimental model aimed at the elaboration of preventive and/or curative treatments of esca syndrome [28].…”

Section: Introductionmentioning

confidence: 99%

On the Applicability of Chitosan Oligomers-Amino Acid Conjugate Complexes as Eco-Friendly Fungicides against Grapevine Trunk Pathogens

et al. 2021

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In a context in which the incidence and severity of grapevine fungal diseases is increasing as a result of both climate change and modern management culture practices, reducing the excessive use of phytosanitary products in viticulture represents a major challenge. Specifically, grapevine trunk diseases (GTDs), caused by several complexes of wood decay or xylem-inhabiting fungi, pose a major challenge to vineyard sustainability. In this study, the efficacy of chitosan oligomers (COS)–amino acid conjugate complexes against three fungal species belonging to the Botryosphaeriaceae family (Neofusicoccum parvum, Diplodia seriata, and Botryosphaeria dothidea) was investigated both in vitro and in planta. In vitro tests led to EC50 and EC90 effective concentrations in the 254.6−448.5 and 672.1−1498.5 µg·mL−1 range, respectively, depending on the amino acid involved in the conjugate complex (viz. cysteine, glycine, proline or tyrosine) and on the pathogen assayed. A synergistic effect between COS and the amino acids was observed against D. seriata and B. dothidea (synergy factors of up to 2.5 and 2.8, respectively, according to Wadley’s method). The formulations based on COS and on the conjugate complex that showed the best inhibition rates, COS−tyrosine, were further investigated in a greenhouse trial on grafted vines of two varieties (”Tempranillo” on 775P and “Garnacha” on 110R rootstock), artificially inoculated with the mentioned three Botryosphaeriaceae species. The in planta bioassay revealed that the chosen formulations induced a significant decrease in disease severity against N. parvum and B. dothidea. In summary, the reported conjugate complexes may be promising enough to be worthy of additional examination in larger field trials.

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“…Cysteine inhibited both spore germination and mycelial growth in a concentration-dependent manner of the fungal pathogens Phaeomoniella chlamydospora and Phaeoacremonium minimum, which cause the grapevine trunk (esca) disease [44]. Using 35 S-cysteine, it was demonstrated that the amino acid was absorbed following leaf spraying and transported to the trunk, which is the area where the fungal pathogens are localized in the course of the development of esca disease [44]. Similar antifungal effects of Cys were also shown for other fungal pathogens such as B. cinerea [45] and Eutypa lata [46].…”

Section: Cysteinementioning

confidence: 99%

The Versatile Roles of Sulfur-Containing Biomolecules in Plant Defense—A Road to Disease Resistance

Künstler

Gullner

Ádám

et al. 2020

Plants

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Sulfur (S) is an essential plant macronutrient and the pivotal role of sulfur compounds in plant disease resistance has become obvious in recent decades. This review attempts to recapitulate results on the various functions of sulfur-containing defense compounds (SDCs) in plant defense responses to pathogens. These compounds include sulfur containing amino acids such as cysteine and methionine, the tripeptide glutathione, thionins and defensins, glucosinolates and phytoalexins and, last but not least, reactive sulfur species and hydrogen sulfide. SDCs play versatile roles both in pathogen perception and initiating signal transduction pathways that are interconnected with various defense processes regulated by plant hormones (salicylic acid, jasmonic acid and ethylene) and reactive oxygen species (ROS). Importantly, ROS-mediated reversible oxidation of cysteine residues on plant proteins have profound effects on protein functions like signal transduction of plant defense responses during pathogen infections. Indeed, the multifaceted plant defense responses initiated by SDCs should provide novel tools for plant breeding to endow crops with efficient defense responses to invading pathogens.

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Cysteine: A multifaceted amino acid involved in signaling, plant resistance and antifungal development

Cited by 19 publications

References 77 publications

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

Plant Phytochemicals in Food Preservation: Antifungal Bioactivity: A Review

On the Applicability of Chitosan Oligomers-Amino Acid Conjugate Complexes as Eco-Friendly Fungicides against Grapevine Trunk Pathogens

The Versatile Roles of Sulfur-Containing Biomolecules in Plant Defense—A Road to Disease Resistance

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