Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome

Archontogeorgis, Kostas; Nena, Evangelia; Tsigalou, Christina; Voulgaris, Athanasios; Xanthoudaki, Maria; Froudarakis, Marios; Steiropoulos, Paschalis

doi:10.1155/2016/8081723

Cited by 20 publications

(15 citation statements)

References 50 publications

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“…The underlying mechanism by which intermittent hypoxia induces IR still remains unclear, but recent data suggest that hypoxia-mediated inflammation of the adipose tissue may be an important contributor [ 31 ]. Hypoxia is the major determinant of renal function in OSAS patients as well [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

Archontogeorgis

Παπάνας

Nena

et al. 2017

TOCMJ

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Background:Obstructive sleep apnoea syndrome (OSAS) has been linked with abnormal glucose metabolism, insulin resistance (IR) and development of diabetes mellitus.Methods:Non-diabetic patients (n=69) with OSAS, diagnosed by polysomnography, were prospectively recruited. To evaluate IR among OSAS patients, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Insulin sensitivity by Quantitative Insulin sensitivity Check Index (QUICKI) were used.Results:HOMA-IR was positively associated with body-mass index (BMI) (ρ=0.364, p=0.002), time with oxyhaemoglobin saturation <90% (ρ=0.291, p=0.015), arousal index (ρ=0.268, p=0.027), Epworth sleepiness scale (ESS) score (ρ=0.293, p=0.019) and negatively with average oxyhaemoglobin saturation (ρ=-0.398, p=0.001) and minimum oxyhaemoglobin saturation (ρ=-0.327, p=0.006). QUICKI was positively associated with forced vital capacity (r=0.301, p=0.014), average oxyhaemoglobin saturation (r=0.443, p<0.001), minimum oxyhaemoglobin saturation (ρ=0.318, p=0.008), and negatively associated with sleep stage transitions (r=-0.266, p=0.032), oxygen desaturation index (r=-0.404, p=0.005), time with oxyhaemoglobin saturation <90% (r=-0.311, p=0.019), arousal index (r=-0.344, p=0.004) and ESS score (r=-0.299, p=0.016). After adjustment for age and BMI, HOMA-IR was associated with sleep stage transitions, time with oxyhaemoglobin saturation <90%, average oxyhaemoglobin saturation, minimum oxyhaemoglobin saturation and arousal index. QUICKI was associated with oxygen desaturation index, sleep stage transitions, ESS score, minimum oxyhaemoglobin saturation and arousal index.Conclusions:An independent association between OSAS and IR in patients without pre-existing diabetes mellitus was observed. Recurrent hypoxia and sleep fragmentation in OSAS are associated with IR in these patients.

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Section: Discussionmentioning

confidence: 99%

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

Archontogeorgis

Παπάνας

Nena

et al. 2017

TOCMJ

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“…Obstructive sleep apnea syndrome is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease 53 . Serum Cystatin C serum levels are increased in obstructive sleep apnea syndrome patients without comorbidities, suggesting an increased renal and cardiovascular disease risk 53 .…”

Section: Cardiovascularmentioning

confidence: 99%

“…In a large study that evaluated the role of early kidney dysfunction as a risk factor for hypertension that included 2,767 individuals with a median follow-up of 3 years, Cystatin C levels were elevated and associated with older age and traditional cardiovascular risk factors 53 . After adjustment for established arterial hypertension risk factors, each increase in serum Cystatin C levels of 15nmol/L was associated with a 15% greater incidence of hypertension 53 .…”

Section: Cardiovascularmentioning

confidence: 99%

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

Viniegra¹,

Shiguetomi²,

Glogauer³

2018

CMRJ

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Cystatin C is a low-molecular-weight biomarker that meets the conditions necessary to be a marker of the glomerular filtration rate. This endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily plays a key role in health and disease. Human cystatin C is encoded by the CST3 gene, ubiquitously expressed at moderate levels throughout the body, given it is produced in all nucleated cells in a constant amount. It is present in all human body fluids, and may be determined in the serum, plasma, capillary blood and urine. In this review, we present and discuss most of the available data from the literature for the use of cystatin C in clinical practice. In addition to a kidney function marker, studies suggest cystatin C could be used as a marker for cardiovascular risk assessment, in predicting and detecting preeclampsia, in patients with malignant neoformations, etc. Local cystatin C deficiency has also been demonstrated in atherosclerosis, aneurismal lesions, among others, suggesting a protective role of cystatin C. Far beyond its humble beginning, it promises uses from prognosis to treatments for everything from prostate cancer to periodontal disease. Cystatin C has begun its journey into a multitude of disciplines; we can only begin to imagine the many more purposes yet to find going forward.

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“…In recent years, there are many studies on the clinical significance of serum Cys C levels changes in respiratory diseases. It has been studied that Cys C plays a role in pathogenesis of obstructive sleep apnea syndrome [10][11][12][13][14][15][16][17][18][19][20], lung malignancy [21], pleural effusions [22], and emphysema [23].…”

Section: Introductionmentioning

confidence: 99%

The association between cystatin C and COPD: a meta-analysis and systematic review

et al. 2020

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Background: In recent years, many studies have discovered that cystatin C (Cys C) may play an important role in respiratory diseases, especially in chronic obstructive pulmonary disease (COPD). However, the findings of these studies were inconsistent. This systematic review and meta-analysis aimed to assess the relationship between serum Cys C and COPD. Methods: We conducted a systematic literature search in PubMed, Embase, Web of Science, Wanfang databases, and the China National Knowledge Infrastructure. The standardized mean difference (SMD), Fisher's Z-value and 95% confidence interval (CI) were calculated to investigate the effect sizes. Subgroup analyses were performed on disease status, ethnicity, assay method, and study design. Sensitivity was performed, and publication bias was assessed. Results: A total of 15 studies, including 4079 COPD patients and 5949 controls, were included in this meta-analysis. The results showed that serum Cys C levels in patients with COPD were significantly higher than those in controls (SMD = 0.99, 95% CI =0.62-1.37, P < 0.001), especially in AECOPD (SMD = 1.59, 95% CI =1.05-2.13, P < 0.001), and there were statistically different among AECOPD and SCOPD (SMD = 0.35, 95% CI =0.10-0.59, P = 0.005). The serum Cys C levels were negatively correlated with FEV1%pre (Z = − 0.45, 95%CI =-0.58-0.32, P = 0.011) and FEV1/FVC (Z = − 0.32, 95%CI =-0.50-0.14, P = 0.006). The serum Cys C levels were independent of ethnicity, assay method, and study design. Conclusion: Serum Cys C levels were associated with COPD and COPD exacerbation, and they were inversely correlated with FEV1%pre and FEV1/FVC.

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Cystatin C Levels in Middle-Aged Patients with Obstructive Sleep Apnea Syndrome

Cited by 20 publications

References 50 publications

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

Insulin Sensitivity and Insulin Resistance in Non-Diabetic Middle-Aged Patients with Obstructive Sleep Apnoea Syndrome

Clinical Role, Diagnostic and Prognostic Value of Human Cystatin C Through the Body

The association between cystatin C and COPD: a meta-analysis and systematic review

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