Cystatin C and Seminal Parameter Evaluation in Patients with End-Stage Renal Disease

Abstract

Objective: We aimed to investigate the possible relationship between seminal parameters and cystatin C seminal levels in an infertility evaluation of chronic hemodialysis patients. Materials and Methods: This was a cross-sectional study, aged 18-60 years, in a group of 60 men undergoing hemodialysis (case) for more than 6 months, and a group of 15 healthy men (control) without clinical or laboratory signs of genitourinary tract infection. We performed a spermogram, hormonal profile, and assessment of leukocytes and cystatin levels in the semen. Results: The ages in the case and control were similar (p = 0.060).The seminal cystatin was significantly different between the case group and control group (41.16 ± 26.59 vs. 79.00 ± 05.68 mg/l, respectively, p < 0.001) and between normospermia and oligospermia (83.50 ± 02.40 vs. 30.34 ± 02.52 mg/l, respectively, p < 0.001). The mean seminal cystatin levels identified by the degrees of oligospermia (severe, moderate, and slim) were similar to each other (p > 0.05) and significantly different (p < 0.05) in relation to normospermia in the case group. The seminal cystatin levels positively correlated (p < 0.05) with sperm motility and sperm density. Conclusion: Seminal cystatin levels are associated with the numerical and motility changes evidenced in the spermogram and may be of help in the initial evaluation of clinical suspicion of sub-fertility and infertility.

Prognostic capabilities of proteomic analysis of seminal plasma in males with azoospermia

“…G. P. Silva и соавт. обнаружили, что концентрация цистатина C в семенной жидкости пациентов на хроническом гемодиализе существенно снижена при олигозооспермии любой степени выраженности, но эти данные трудно экстраполировать на мужчин с сохранной функцией почек [15]. Та же группа авторов изучила концентрацию альфа-1-кислого гликопротеина (орозомукоида) в семенной плазме пациентов на хроническом гемодиализе, но не выявила никакой связи ни со степенью нарушения почечной функции, ни с показателями спермограммы [16].…”