Cypermethrin toxication leads to histopathological lesions and induces inflammation and apoptosis in common carp ( Cyprinus carpio  L.)

Arslan, Harun; Özdemir, Selçuk; Altun, Serdar

doi:10.1016/j.chemosphere.2017.04.057

Cited by 51 publications

(21 citation statements)

References 62 publications

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“…Cypermethrin was also reported to increase the expression of p53 (along with caspase-3) in rat striatum and substantia nigra (19,20), and these findings were associated with apoptosis. One in vitro study in common carp brain cells (30) suggested that cypermethrin could induce apoptosis through the extrinsic pathway, judging by the elevated caspase 8 levels.…”

Section: Apoptosismentioning

confidence: 99%

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Mohammadi

Ghassemi-Barghi

Malakshah

et al. 2019

Archives of Industrial Hygiene and Toxicology

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Pyrethroids are a class of synthetic insecticides that are used widely in and around households to control the pest. Concerns about exposure to this group of pesticides are now mainly related to their neurotoxicity and nigrostriatal dopaminergic neurodegeneration seen in Parkinson’s disease. The main neurotoxic mechanisms include oxidative stress, inflammation, neuronal cell loss, and mitochondrial dysfunction. The main neurodegeneration targets are ion channels. However, other receptors, enzymes, and several signalling pathways can also participate in disorders induced by pyrethroids. The aim of this review is to elucidate the main mechanisms involved in neurotoxicity caused by pyrethroids deltamethrin, permethrin, and cypermethrin. We also review common targets and pathways of Parkinson’s disease therapy, including Nrf2, Nurr1, and PPARγ, and how they are affected by exposure to pyrethroids. We conclude with possibilities to be addressed by future research of novel methods of protection against neurological disorders caused by pesticides that may also find their use in the management/treatment of Parkinson’s disease.

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Section: Apoptosismentioning

confidence: 99%

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Mohammadi

Ghassemi-Barghi

Malakshah

et al. 2019

Archives of Industrial Hygiene and Toxicology

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“…Later, the quality of total RNA samples was evaluated with gel electrophoresis ( Figure S1). cDNA synthesis was done with QuantiTect reverse transcription (Qiagen, Cat: 330411 Germany) [16,17]. measures the transcript levels of TCONS_00042053, TCONS_00055411, TCONS_00068290, TCONS_00071212, TCONS_00158814, TCONS_00135045, FCGR2B, CENPE, RETSAT, ACSBG2, TBC1D1, MAP3K1, UGDH, and NUCB2 in the milk-derived exosomes using a ROTOR-GENE Q 5plex HRM Real-Time PCR Detection System (Qiagen, Germany).…”

Section: Total Rna Extraction and Cdna Processesmentioning

confidence: 99%

“…2x QuantiTect SYBR Green PCR Master Mix (Qiagen, Cat: 330500, Germany) was used for qPCR. The qPCR products were evaluated with agarose gel electrophoresis and melting curve analysis [16,17], and the expression fold changes were determined in accordance with the 2 -ΔΔCT method [18].…”

Section: Total Rna Extraction and Cdna Processesmentioning

confidence: 99%

Expression profiles of lincRNA and mRNA related to milk yield and milk composition traits in the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı cows

Özdemir¹,

Eltas²,

Çulha³

2020

Turk J Vet Anim Sci

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Introduction Several nutrients, growth factors, metabolic hormones, and cytokines are found in bovine milk; it is well known that bovine milk contains important nutrients for humans [1,2]. Milk yield is one of the most important issues faced by dairy cattle farms [3]. In addition, factors such as protein and fat percentage are important determinants of milk quality [4]. Breeding studies to increase milk yield are very important for the continuity of dairy cattle farms. In recent years, the most common breeding technique used for this purpose is genomic selection, including genomewide association studies (GWASs) [3], gene expression [4], and quantitative trait locus (QTL) [5]. Milk produced by humans and several other animal species such as cows, swine, and yaks contains different types of extracellular vesicles (EVs), such as microvesicles, exosomes, and apoptotic bodies, which play a role in several biological pathways. Moreover, EVs are related to mammary gland health. Most exosomes, which are a type of EV, are from 30 to 100 nm in size, and are released from different populations of cells into the microenvironment, under both normal and pathological events [6,7]. When proteomic analysis is performed, exosomes derived from milk can be distinguished from milk fat globule membranes by their enzymatic and transport differences [8]. Exosomes carry circulating nucleic acids, including mRNA, microRNA (miRNA), ribosomal RNA, long noncoding RNA (lncRNA), transfer RNA, and variably DNA, all of which also carry proteins. These nucleic acids, which are found in exosomes, can pass from one cell to another and affect protein production in cells [9]. With new sequencing technology, a growing number of transcripts have been identified in humans and animals. The most prominent of these transcripts are noncoding RNAs (ncRNAs). ncRNAs are miRNA, tRNA halves (tiRNAs), and Piwi-interacting RNA (piRNAs) with lengths of less than 200 bp and lncRNAs with lengths of more than 200 bp. lncRNAs can be characterized as antisense lncRNAs, intronic lncRNAs, bidirectional lncRNAs, intergenic lncRNAs (lincRNA), and senseoverlapping lncRNAs based on their locations. Recent studies have revealed the discovery of several lncRNAs in eukaryotic organisms, especially lincRNA, which play a role in chromatin modification, epigenetic regulation, genomic imprinting, and transcriptional control. Preand posttranslational mRNA processing has also been

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“…Піретроїдні інсектициди є високотоксичними для риб [9,10]. Показаний нейротоксичний ефект у дорослих особин риб Poecilia reticulata за дії бета-циперметрину, що проявлявся у зміні їхніх поведінкових реакцій [11].…”

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Evaluation of neurotoxic effect of synthetic pyrethroids: comparative characteristics of neurotoxic action of cypermethrin and zeta-cypermethrin in pre- and postnatal period

Rashkivska

2018

UJMTA

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Synthetic pyrethroids (SPs) are insecticides used in everyday life, in rural and forestry farms. The wide use of SPs is due to their ability to rapidly biodegradate, relatively low toxicity to mammals and high insecticidal activity. Due to the similarity of neurochemical processes, these compounds may also exhibit their neurotoxic properties in non-target objects, in addition to the effects on pests. An overview ofscientific literature has shown that the best biological model for investigating the potential neurotoxic effects of SPs and extrapolation of obtained experimental data to humans is the rat. Objective — to investigate the effect of cypermethrin and zeta-cypermethrin in pre- and postnatal development; to conduct a comparative study of the neurotoxic properties of cypermethrin and zeta-cypermethrin. Methods —the article presents the data of two conducted experiments studying the neurotoxic activity of representatives ofpyrethroid insecticides — cypermethrin and zeta-cypermethrin. Results — it was found that cypermethrin and zeta-cypermethrin exhibit gender-related sensitivity: young male rats were more susceptible to cypermethrin and zeta-cypermethrin compared to females. The effect of cypermethrin and zeta-cypermethrin in the pre-and postnatal period is dose-dependent. Effect of cypermethrin in doses of 17,5 and 35 mg/kg and zeta-cypermethrin at a dose of 12,5 mg/kg in the pre- and postnatal period does not cause a neurotoxic effect in offspring. Cypermethrin exposure at a dose of 70 mg/ kg and zeta-cypermethrin exposure in doses of 35 and 70 mg/kg causes changes in behavioural reactions of offspring of both genders. Administration of cypermethrin at a dose of 70 mg/kg in the- pre and postnatal period affects motor activity and cognitive activity of young male rats (in terms of increasing the latent period of the first movement and decreasing the number of crossed squares). Administration of zeta-cypermethrin at a dose of 70 mg/kg causes in the offspring of both genders disorders in the psycho-emotional state (decrease in the parameters of the grooming), inhibition of motor and cognitive activity (decrease of the number of crossed squares and pointing for males, decrease of the number of crossed squares for females), and reduction of adaptive properties (increase of latent period of the first movement for males). Under the action of zeta-cypermethrin at a dose of 35 mg/kg in males, an increase in anxiety was observed (decrease in the total duration of the grooming). Zeta-cypermethrin showed a greater neurotoxicity on offspring compared with cypermethrin. Key words: pesticides, synthetic pyrethroids, cypermethrin, zeta-cypermethrin, nervous system, prenatal period, postnatal period, behavioural reactions.

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Cypermethrin toxication leads to histopathological lesions and induces inflammation and apoptosis in common carp ( Cyprinus carpio L.)

Cited by 51 publications

References 62 publications

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Pyrethroid exposure and neurotoxicity: a mechanistic approach

Expression profiles of lincRNA and mRNA related to milk yield and milk composition traits in the milk-derived exosomes of Holstein and Doğu Anadolu Kırmızısı cows

Evaluation of neurotoxic effect of synthetic pyrethroids: comparative characteristics of neurotoxic action of cypermethrin and zeta-cypermethrin in pre- and postnatal period

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