Cypermethrin inhibits Leydig cell development and function in pubertal rats

Li, Shijun; Wang, Yun; Zou, Cheng; Zhu, Qiqi; Wang, Yiyan; Chen, Haiqiong; Yang, Wenjing; Tu, Yuhan; Yan, Haoni; Li, Xiaoheng; Ge, Ren‐Shan

doi:10.1002/tox.23473

Cited by 3 publications

(1 citation statement)

References 43 publications

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“…CYP is considered able to alter immune functionality in rats (Liu et al 2006 ) and exert myelotoxicity in human cells (Mandarapu and Mrakhya 2015 ). The endocrine effects of CYP are debated, and several evidences indicate its ability to interfere with the endocrine system (Jin et al 2011 ; Singh et al 2020 ; Irani et al 2022 ; Li et al 2022b ), but recently it has been classified as unlikely to cause endocrine disruption (EC 2019 ). Finally, VIN effects on the endocrine system have been reported, evidencing altered male reproduction as the main effect, inducing a lower sperm quality and number, epididymal morpholohical changes, and prostate abnormalities (Anway and Skinner 2008 ; Paoloni-Giacobino 2014 ; Feijó et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Maddalon,

Cari,

Iulini

et al. 2023

Arch Toxicol

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Humans can be exposed to endocrine disruptors (EDs) in numerous ways. EDs can interfere with endogenous hormones at different levels, resulting in numerous adverse human health outcomes, including immunotoxicity. In this regard, this study aimed to investigate in vitro the possible effects of EDs on immune cells and possible gender differences. Peripheral blood mononuclear cells from healthy humans, both males and females, were exposed to 6 different EDs, namely atrazine (herbicide), cypermethrin (insecticide), diethyl phthalate (plasticizer), 17α-ethynylestradiol (contraceptive drug), perfluorooctanesulfonic acid (persistent organic pollutant), and vinclozolin (fungicide). We evaluated the effect of EDs on RACK1 (receptor for activated C kinase 1) expression, considering it as a bridge between the endocrine and the immune system, and putatively used as screening tool of immunotoxic effects of EDs. The exposure to EDs resulted at different extent in alteration in RACK1 expression, pro-inflammatory activity, natural killer lytic ability, and lymphocyte differentiation, with sex-related differences. In particular, diethyl phthalate and perfluorooctanesulfonic acid resulted the most active EDs tested, with gender differences in terms of effects and magnitude. The results from our study evidenced the ability of EDs to directly affect immune cells.

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Section: Introductionmentioning

confidence: 99%

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Maddalon,

Cari,

Iulini

et al. 2023

Arch Toxicol

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Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches

Elblehi,

Hafez,

El-Far

2023

Environ Sci Pollut Res

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Cypermethrin (CYP) is a synthetic pyrethroid utilized as an insecticide in agriculture and various pest eradication programs. However, it induces numerous health hazards for animals and humans. Therefore, the current study used Panax ginseng root extract (ginseng) to reduce the hepatorenal damage caused by commercially used CYP. Thirty-two male Wistar albino rats were distributed into control, ginseng (300 mg/kg B.W/day), CYP (4.67 mg/kg B.W.), and Ginseng+CYP (rats received both CYP and ginseng). All treatments were administered orally for 30 consecutive days. Cypermethrin induced harmful effects on hepatic and renal tissues through a substantial decline in body weight in addition to a considerable increase in liver enzymes, functional renal markers, and cholesterol. Also, CYP significantly decreased acetylcholinesterase (AChE) activity and increased pro-inflammatory cytokines (interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α)). Moreover, a marked increase in malondialdehyde level with a significant drop in reduced glutathione level and total superoxide dismutase (T-SOD) and catalase (CAT) activities was reported in the CYP group in kidney and liver tissues. Additionally, CYP exhibited affinities to bind and inhibit AChE and antioxidant enzymes (T-SOD and CAT) in rats following the molecular docking modeling. The apparent hepatorenal oxidative damage was linked with obvious impairments in the liver and kidney histoarchitecture, immunohistochemical staining of B cell lymphoma-2 (Bcl-2), and caspase-3 proteins. Ginseng reduced CYP’s oxidative alterations by repairing the metabolic functional markers, improving antioxidant status, reducing the inflammatory response, and enhancing the molecular docking evaluation. It also ameliorated the intensity of the histopathological alterations and improved the immunohistochemical staining of Bcl-2 and caspase-3 proteins in the liver and kidney tissues. Finally, concomitant oral administration of ginseng mitigated CYP-prompted hepatorenal damage through its antioxidant, anti-inflammatory, and anti-apoptotic potentials. Graphical Abstract

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Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility

Uwamahoro,

Jo,

Jang

et al. 2024

IJMS

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Pesticides serve as essential tools in agriculture and public health, aiding in pest control and disease management. However, their widespread use has prompted concerns regarding their adverse effects on humans and animals. This review offers a comprehensive examination of the toxicity profile of pesticides, focusing on their detrimental impacts on the nervous, hepatic, cardiac, and pulmonary systems, and their impact on reproductive functions. Additionally, it discusses how pesticides mimic hormones, thereby inducing dysfunction in the endocrine system. Pesticides disrupt the endocrine system, leading to neurological impairments, hepatocellular abnormalities, cardiac dysfunction, and respiratory issues. Furthermore, they also exert adverse effects on reproductive organs, disrupting hormone levels and causing reproductive dysfunction. Mechanistically, pesticides interfere with neurotransmitter function, enzyme activity, and hormone regulation. This review highlights the effects of pesticides on male reproduction, particularly sperm capacitation, the process wherein ejaculated sperm undergo physiological changes within the female reproductive tract, acquiring the ability to fertilize an oocyte. Pesticides have been reported to inhibit the morphological changes crucial for sperm capacitation, resulting in poor sperm capacitation and eventual male infertility. Understanding the toxic effects of pesticides is crucial for mitigating their impact on human and animal health, and in guiding future research endeavors.

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Cypermethrin inhibits Leydig cell development and function in pubertal rats

Cited by 3 publications

References 43 publications

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Panax ginseng ameliorates hepatorenal oxidative alterations induced by commercially used cypermethrin in male rats: experimental and molecular docking approaches

Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility

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