Cypermethrin induced damage in genomic DNA and histopathological changes in brain and haematotoxicity in rats: The protective effect of sesame oil

Hussien, Hend M.; Abdou, Heba M.; Yousef, Mokhtar I.

doi:10.1016/j.brainresbull.2011.10.020

Cited by 70 publications

(39 citation statements)

References 46 publications

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“…Aphantoxins may reduce the synthesis of AChE in these neurons, thus inhibiting neurotransmission via voltage-gated sodium channels (Hussien et al, 2013). The present and previous results suggest that aphantoxins/PSPs may damage the structure and function of the liver by inhibiting AChE activity and thus affecting cholinergic neurotransmission in zebrafish liver (Azevedo et al, 2013).…”

Section: Ache Activitysupporting

confidence: 50%

“…MAO inhibition represents reduced inactivation of monoaminergic neurotransmitters (Hussien et al, 2013). MAO inhibition has previously been investigated mostly in the brains of mammals, including humans, while MAO activity in fish remains poorly understood (Yagodina et al, 2006).…”

Section: Mao Activitymentioning

confidence: 99%

“…Histological and/or ultrastructural alterations, and changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), reactive oxygen species (ROS), and total antioxidative capacity (T-AOC) represent valuable parameters that can be used to assess the effects of exposure to a variety of anthropogenic or natural pollutants in fish, which demonstrate representative physiological, biochemical and histopathological responses to stress (Abdel-Moneim, 2014;Bacchetta et al, 2014;Jia et al, 2014). Monoamine oxidase (MAO) and acetylcholinesterase (AChE) are crucial enzymes involved in the decomposition of monoamine neurotransmitters such as norepinephrine/epinephrine and others from sympathetic nerves, and cholinergic neurotransmitters from vagus nerves in animal liver (Askar et al, 2011;Hussien et al, 2013). Previous studies have investigated the effects of atrazine, pesticides and microcystins on these parameters in animals (Hussien et al, 2013;Vasanthi et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Monoamine oxidase (MAO) and acetylcholinesterase (AChE) are crucial enzymes involved in the decomposition of monoamine neurotransmitters such as norepinephrine/epinephrine and others from sympathetic nerves, and cholinergic neurotransmitters from vagus nerves in animal liver (Askar et al, 2011;Hussien et al, 2013). Previous studies have investigated the effects of atrazine, pesticides and microcystins on these parameters in animals (Hussien et al, 2013;Vasanthi et al, 2014). However, there is little information on the effects of cyanobacterial neurotoxins or PSPs on these markers of hepatic detoxification and metabolism in fish (Apte and Krishnamurthy, 2011;Azevedo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Zhang

et al. 2014

Aquatic Toxicology

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Section: Ache Activitysupporting

confidence: 50%

Section: Mao Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Zhang

et al. 2014

Aquatic Toxicology

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“…The fatty acid composition includes 43% oleic and linoleic each, 9% palmitic fatty acids, and 4% stearic. Sesame oil intake is related with a decreased risk of hypertensive and cardiovascular disease (Wu et al, 2009a), partial adhesive small bowel obstruction (Hsu et al, 2016), cypermethrin induced brain toxicity (Hussien et al, 2013), and it has positive effects on type 2 diabetes mellitus (Sankar et al, 2011), cough in children (Saab et al, 2006). On the other hand, sesame oil has beneficial effects on anticancer (Salerno & Smith, 1991), anti-inflammatory and antibacterial (Hsu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Effect of pre-emulsified sesame oil on physical-chemical and rheological properties of pork batters

Kang

Zhu

et al. 2017

Food Sci. Technol

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Physical-chemical and rheological properties of pork batters as affected by replacing pork back-fat with pre-emulsified sesame oil were investigated. Replacement of pork back-fat with pre-emulsified sesame oil, improved L* value, moisture and protein content, hardness, cohesiveness, and chewiness, declined a* value, fat content and energy, but not affect cooking yield. When used pre-emulsified sesame oil to replace pork back-fat 50%, the sample had the highest L* value and texture. According to the results of dynamic rheological, replaced pork back-fat by pre-emulsified sesame oil increased the storage modulus (G') values at 80 °C, and formed firm gel. The result of Low-field nuclear magnetic resonance (LF-NMR) shown that the batters with pre-emulsified sesame oil had higher water holding capacity than the control. Overall, the batters with pre-emulsified sesame oil enabled lowering of fat and energy contents, making the pork batter had better texture.

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Neurodevelopmental consequences of gestational and lactational exposure to pyrethroids in rats

2015

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Indiscriminate use of pyrethroids has raised serious health related concerns, especially about their effects on children. The present study was designed to assess the developmental neurotoxicity of two pyrethroids; bifenthrin (BIF) and β-cyfluthrin (CYF) administered at 1/15 of LD in rats. Pregnant females were exposed to the test compounds orally throughout gestation and lactation periods. Neonates were weighed and sexed at birth and were observed for any gross abnormality. Growth, viability and weaning indices were calculated during the lactation period. Exposure to both the compounds did not alter the physical developmental parameters viz. eye opening, pinna detachment, and fur appearance. CYF significantly impaired growth and survivability of pups. Behavioral endpoints assessed in neonates (surface righting, pivoting, and negative geotaxis reflex) as well as adults (motor activity and motor coordination) exhibited marked effect of CYF treatment. Administration of BIF to pregnant dams impaired pivoting in neonates. Decreased locomotion in the open-field and impaired rota-rod performance were also witnessed in BIF-exposed animals. Enhanced oxidative stress was seen in corpus striatum, cerebellum, and hippocampus regions of the brain; reduced catalase, superoxide dismutase, and glutathione peroxidase activities were measured in BIF and CYF treated weanlings. Acetylcholinesterase activity was also found to be lowered following administration of both compounds at PND 21. The present results suggest that exposure to pyrethroids during critical periods of growth can induce long term effects on the behavior of animals. © 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1761-1770, 2016.

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Cypermethrin induced damage in genomic DNA and histopathological changes in brain and haematotoxicity in rats: The protective effect of sesame oil

Cited by 70 publications

References 46 publications

Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Morphological alterations and acetylcholinesterase and monoamine oxidase inhibition in liver of zebrafish exposed to Aphanizomenon flos-aquae DC-1 aphantoxins

Effect of pre-emulsified sesame oil on physical-chemical and rheological properties of pork batters

Neurodevelopmental consequences of gestational and lactational exposure to pyrethroids in rats

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