Cypermethrin and chlorpyrifos raises serum urea level and causes abnormal sperm morphology in Wistar rats

Abstract

Chlorpyrifos (organophosphate) and cypermethrin (pyrethroid) are insecticides, which are widely used for agricultural as well as for domestic purposes. This study investigated the toxicological effect of chlorpyrifos and cypermethrin on selected organs and tissues of male Wistar rats. Nine (9) male Wistar rats were randomly grouped into three and were orally given chlorpyrifos or cypermethrin, while the control group was given distilled water for 28 days. The results revealed a significant increase (p<0.05) in rat serum AST activity for the chlorpyrifos and cypermethrin groups. Also, there was significant elevation in serum urea following oral exposure to either chlorpyrifos or cypermethrin. Conversely, a reduction in the rat liver ALP activity for treatment with cypermethrin or chlorpyrifos was recorded. The histology results revealed that the administration of chlorpyrifos but not cypermethrin for 28 days has no significant effect on the biochemical properties and sperm morphology of the rats. Taken together, findings indicate that cypermethrin and chlorpyrifos exposure in rats predisposes to renal injury, while altering sperm morphology.

Impact of Watermelon (Citrallus lanatus) on Male Fertility

“…Globally, over 50 million couples report being affected by fertility challenges, with about 30-50 % citing male reproductive disorders as the underlying issue (Fainberg & Kashanian, 2019;Olaolu et al, 2018). Major causes of male infertility include reduced semen quality, dysfunctional hypothalamic-pituitary-gonadal axis, infections, and endocrine disorders (Gunes et al, 2015;Iyiola et al, 2019;Kayode et al, 2020a;Musavi et al, 2018;Nwonuma et al, 2021;Olaolu & Rotimi, 2017;Pourmasumi et al, 2017). Potential treatment options include surgical interventions, hormone therapy, and specialized assisted reproductive technology (ART).…”