Testicular deficiency associated with exposure to cypermethrin, imidacloprid, and chlorpyrifos in adult rats

Abdel-Razik, Reda; Mosallam, Eman; Hamed, Nadia; Badawy, Mohamed E.I.; Abo-El-Saad, Mahmoud M.

doi:10.1016/j.etap.2021.103724

Cited by 17 publications

(9 citation statements)

References 65 publications

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Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

“…Table 1 [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] includes a summary of the effects of several CECs grouped as pesticides and pharmaceuticals on male fertility (e.g., hormone levels, testis size and structure, and sperm characteristics) in different species. Example of CECs listed in Table 1 [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] included both in vivo and in vitro treatments and illustrates the broad negative reproductive effects that CECs have. Overall, collective findings indicate defects in reproductive function across a wide range of marine and terrestrial animals including fish [70], birds [71], alligators, turtles, salamanders [72], mice [73], and panthers [74], when exposed to CECs.…”

Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

“…Therefore, CECs causing hormone disruption or direct damage to spermatogenesis may be responsible for changes in male reproduction (Figure 2) [13,75]. Table 1 [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69] includes a summary of the effects of several CECs grouped as pest cides and pharmaceuticals on male fertility (e.g., hormone levels, testis size and structure and sperm characteristics) in different species. Example of CECs listed in Table 1 [54-69 included both in vivo and in vitro treatments and illustrates the broad negative reproduc tive effects that CECs have.…”

Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

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Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Marcu

Keyser

Petrik

et al. 2023

Toxics

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Approximately 9% of couples are infertile, with half of these cases relating to male factors. While many cases of male infertility are associated with genetic and lifestyle factors, approximately 30% of cases are still idiopathic. Contaminants of emerging concern (CECs) denote substances identified in the environment for the first time or detected at low concentrations during water quality analysis. Since CEC production and use have increased in recent decades, CECs are now ubiquitous in surface and groundwater. CECs are increasingly observed in human tissues, and parallel reports indicate that semen quality is continuously declining, supporting the notion that CECs may play a role in infertility. This narrative review focuses on several CECs (including pesticides and pharmaceuticals) detected in the nearshore marine environment of False Bay, Cape Town, South Africa, and deliberates their potential effects on male fertility and the offspring of exposed parents, as well as the use of spermatozoa in toxicological studies. Collective findings report that chronic in vivo exposure to pesticides, including atrazine, simazine, and chlorpyrifos, is likely to be detrimental to the reproduction of many organisms, as well as to sperm performance in vitro. Similarly, exposure to pharmaceuticals such as diclofenac and naproxen impairs sperm motility both in vivo and in vitro. These contaminants are also likely to play a key role in health and disease in offspring sired by parents exposed to CECs. On the other side of the double-edged sword, we propose that due to its sensitivity to environmental conditions, spermatozoa could be used as a bioindicator in eco- and repro-toxicology studies.

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Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

Section: Impact Of Cecs On Male Fertilitymentioning

confidence: 99%

See 1 more Smart Citation

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Marcu

Keyser

Petrik

et al. 2023

Toxics

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“…Furthermore, amitraz (AMZ), a formamidine pesticide widely used as an insecticide and acaricide, has been shown to induce alterations in bovine sperm, potentially affecting male fertility at concentrations found in the environment ( 307 ). Similarly, exposure to other pesticides such as diazinon (DZN) ( 308 ), pyridaben (PDB) ( 309 ), bifenthrin (BF) ( 310 ), flurochloridone (FLC) ( 311 ), fipronil (FPN) ( 312 ), etoxazole (ETX) ( 313 ), imidacloprid (IMI) ( 314 , 315 ), atrazine (ATR) ( 316 , 317 ), cypermethrin (CYP) ( 314 , 318 ), chlorpyrifos (CPF) ( 314 , 319 – 322 ), chlorpyrifos ( 323 , 324 ), simazine ( 325 ), endosulfan ( 191 ), and deltamethrin ( 318 ) could lead to a significant decrease in sperm count, motility, normality, vitality, and an increase in deformity rates. Moreover, a significant decrease in daily sperm production, epididymal sperm count, motile, viable, and hypo-osmotic swelling-tail swelled sperm was observed in mancozeb-treated rats ( 326 ).…”

Section: Introductionmentioning

confidence: 99%

The adverse role of endocrine disrupting chemicals in the reproductive system

Pan,

Liu,

et al. 2024

Front. Endocrinol.

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Reproductive system diseases pose prominent threats to human physical and mental well-being. Besides being influenced by genetic material regulation and changes in lifestyle, the occurrence of these diseases is closely connected to exposure to harmful substances in the environment. Endocrine disrupting chemicals (EDCs), characterized by hormone-like effects, have a wide range of influences on the reproductive system. EDCs are ubiquitous in the natural environment and are present in a wide range of industrial and everyday products. Currently, thousands of chemicals have been reported to exhibit endocrine effects, and this number is likely to increase as the testing for potential EDCs has not been consistently required, and obtaining data has been limited, partly due to the long latency of many diseases. The ability to avoid exposure to EDCs, especially those of artificially synthesized origin, is increasingly challenging. While EDCs can be divided into persistent and non-persistent depending on their degree of degradation, due to the recent uptick in research studies in this area, we have chosen to focus on the research pertaining to the detrimental effects on reproductive health of exposure to several EDCs that are widely encountered in daily life over the past six years, specifically bisphenol A (BPA), phthalates (PAEs), polychlorinated biphenyls (PCBs), parabens, pesticides, heavy metals, and so on. By focusing on the impact of EDCs on the hypothalamic-pituitary-gonadal (HPG) axis, which leads to the occurrence and development of reproductive system diseases, this review aims to provide new insights into the molecular mechanisms of EDCs’ damage to human health and to encourage further in-depth research to clarify the potentially harmful effects of EDC exposure through various other mechanisms. Ultimately, it offers a scientific basis to enhance EDCs risk management, an endeavor of significant scientific and societal importance for safeguarding reproductive health.

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“…It has been reported that with the wide use of pesticides in the control of agriculture and residential pests, organophosphate (OP) insecticides, a largest and most diverse group, cause the adverse effects on the reproductive system of consumers (Fucic et al, 2021). An increasing number of reports has demonstrated that OP insecticides destroy the functions of ovary and testis, and increase the risk of infertility (Nishi and Hundal, 2013;Abdel-Razik et al, 2021;Ubaid Ur Rahman et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Pterostilbene Alleviates Chlorpyrifos-Induced Damage During Porcine Oocyte Maturation

Guo¹,

Zhao²,

Ye³

2021

Front. Cell Dev. Biol.

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Chlorpyrifos (CPF), a widely used organophosphate pesticide, is reported to severely impair mammalian reproductive system. Pterostilbene (PTS), an effective free radical scavenger, is considered as beneficial for mammalian reproduction. However, the toxicity of CPF on oocyte maturation and whether PTS can eliminate the detrimental effect of CPF on oocytes remain unclear. Here, porcine oocytes were applied to investigate the potential effect and possible mechanism of CPF and PTS during oocyte maturation. This work demonstrated that CPF significantly delayed the meiotic progression and decreased the polar body extrusion by disturbing spindle assembly and chromosome alignment and causing DNA damage in oocytes (p < 0.05). And, CPF significantly impaired oocyte cytoplasmic maturation by inducing the high level of reactive oxygen species and decreasing glutathione content (p < 0.05). Moreover, CPF significantly triggered embryo apoptosis and reduced the blastocyst rate and cell number following parthenogenetic activation (p < 0.05). Whereas CPF-exposed oocytes were treated with PTS, these defects caused by CPF were obviously rescued, and oocyte maturation and subsequent embryonic development were also significantly ameliorated (p < 0.05). In conclusion, these results revealed that CPF exerted the toxic effect on porcine oocytes, while PTS effectively alleviated CPF-induced damage on oocytes. This work provides a potential strategy to protect oocyte maturation in mammalian species.

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Testicular deficiency associated with exposure to cypermethrin, imidacloprid, and chlorpyrifos in adult rats

Cited by 17 publications

References 65 publications

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

The adverse role of endocrine disrupting chemicals in the reproductive system

Pterostilbene Alleviates Chlorpyrifos-Induced Damage During Porcine Oocyte Maturation

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