CypA: A Potential Target of Tumor Radiotherapy and/or Chemotherapy

Abstract

: Cyclophilin A (CypA) is a ubiquitous and highly conserved protein. CypA, the intracellular target protein for the immunosuppressant cyclosporine A (CsA), plays important cellular roles through peptidyl-prolyl cis-trans isomerase (PPIase). Increasing evidence shows that CypA is up-regulated in a variety of human cancers. In addition to being involved in the occurrence and development of multiple tumors, overexpression of CypA also has been shown to be strongly associated with malignant transformation. Surgery, chemotherapy and radiotherapy are the three main treatments for cancer. Chemotherapy and radiotherapy are often used as direct or adjuvant treatments for cancer. However, various side effects and resistance to both chemotherapy and radiotherapy bring great challenges to these two forms of treatment. According recent reports, CypA can improve the chemosensitivity and/or radiosensitivity of cancers, possibly by affecting the expression of drug-resistant related proteins, cell cycle arrest and activation of the mitogen-activated protein kinase (MAPK) signaling pathways. In this review, we focus on the role of CypA in cancer, the impact on cancer chemotherapeutic and radiotherapy sensitivity, and the mechanism of action. It is suggested that CypA may be a novel potential therapeutic target for cancer chemotherapy and/or radiotherapy.

A novel necroptosis related gene signature and regulatory network for overall survival prediction in lung adenocarcinoma

“…Another report showed that PPIA could promote cancer metastasis in NSCLC through p38 MAPK 55 . In addition, the expression of PPIA is affected by chemotherapeutic drugs, and the overexpression of PPIA can render an organism resistant to chemotherapeutic drugs, which in turn become ineffective 56 , 57 .…”

Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop

“…Whereas, the mechanism of this unique virus in NPC have not been fully illustrated. CYPA has been found to be overexpressed and involved in the development of several cancers such as colorectal cancer and breast cancer ( Chu et al., 2021 ; Davra et al., 2020 ; Yamamoto et al., 2020 ), and is regarded as a key player of human diseases ( Nigro et al., 2013 ). In the previous work of our laboratory, CYPA was found to be upregulated in both NPC tissues and sera exosomes ( Liu et al., 2019a ; Yang et al., 2014 ).…”

Fabrication of a Novel Au Star@AgAu Yolk-Shell Nanostructure for Ovarian Cancer Early Diagnosis and Targeted Therapy

“…According to previous reports and our research, the concentration of CYPA in patients with early ovarian cancer was significantly increased, compared with healthy women and benign group, and the proportion of CYPA positive reaction was higher in I/II stage. [8][9][10] In addition, the secretion of CYPA in serous ovarian cancer is much higher than that in nearby tissues, and the advanced of ovarian cancer is also closely related to the expression of CYPA. 10 All these indicate that the overexpression of CYPA is intimately associated with the occurrence of ovarian cancer.…”