Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop

Xin, Shuyu; Liu, Lingzhi; Li, Yanling; Yang, Jing; Zuo, Lielian; Cao, Pengfei; Yan, Qijia; Shen, Li; Li, Yang; Cui, Taimei; Lu, Jianhong

doi:10.1016/j.virs.2022.09.001

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Virologica Sinica

2022

DOI: 10.1016/j.virs.2022.09.001

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Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop

Shuyu Xin

Lingzhi Liu²,

Yanling Li³

et al.

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Cited by 3 publications

References 56 publications

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The effects of CypA on apoptosis: potential target for the treatment of diseases

Chen,

Zeng,

Luo

et al. 2023

Appl Microbiol Biotechnol

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The effects of CypA on apoptosis: potential target for the treatment of diseases

Chen,

Zeng,

Luo

et al. 2023

Appl Microbiol Biotechnol

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Update on the Regulation and Maintenance of Epstein-Barr Virus Latency

Chen,

Li,

Qin

et al. 2024

Curr Clin Micro Rpt

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A Proteomic Analysis of Nasopharyngeal Carcinoma in a Moroccan Subpopulation

Reffai,

Hori,

Adusumilli

et al. 2024

Cancers

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Background: Nasopharyngeal carcinoma (NPC) is a distinct cancer of the head and neck that is highly prevalent in Southeast Asia and North Africa. Though an extensive analysis of environmental and genetic contributors has been performed, very little is known about the proteome of this disease. A proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissues can provide valuable information on protein expression and molecular patterns for both increasing our understanding of the disease and for biomarker discovery. To date, very few NPC proteomic studies have been performed, and none focused on patients from Morocco and North Africa. Methods: Label-free Liquid Chromatography–Tandem Mass Spectrometry (LC-MS/MS) was used to perform a proteomic analysis of FFPE tissue samples from a cohort of 41 NPC tumor samples of Morocco and North Africa origins. The LC-MS/MS data from this cohort were analyzed alongside 21 healthy controls using MaxQuant 2.4.2.0. A differential expression analysis was performed using the MSstats package in R. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional annotations were carried out using the DAVID bioinformatic tool. Results: 3341 proteins were identified across our NPC cases, revealing three main clusters and five DEPs with prognostic significance. The sex disparity of NPC was investigated from a proteomic perspective in which 59 DEPs were found between males and females, with significantly enriched terms associated with the immune response and gene expression. Furthermore, 26 DEPs were observed between patients with early and advanced stages of NPC with a significant cluster related to the immune response, implicating up-regulated DEPs such as IGHA, IGKC, and VAT1. Across both datasets, 6532 proteins were quantified between NPC patients and healthy controls. Among them, 1507 differentially expressed proteins (DEPs) were observed. GO and KEGG pathway analyses showed enriched terms of DEPs related to increased cellular activity, cell proliferation, and survival. PI3K and MAPK proteins as well as RAC1 BCL2 and PPIA were found to be overexpressed between cancer tissues and healthy controls. EBV infection was also one of the enriched pathways implicating its latent genes like LMP1 and LMP2 that activate several proteins and signaling pathways including NF-Kappa B, MAPK, and JAK-STAT pathways. Conclusion: Our findings unveil the proteomic landscape of NPC for the first time in the Moroccan population. These studies additionally may provide a foundation for identifying potential biomarkers. Further research is still needed to help develop tools for the early diagnosis and treatment of NPC in Moroccan and North African populations.

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Cyclophilin A binds to AKT1 and facilitates the tumorigenicity of Epstein-Barr virus by mediating the activation of AKT/mTOR/NF-κB positive feedback loop

Cited by 3 publications

References 56 publications

The effects of CypA on apoptosis: potential target for the treatment of diseases

The effects of CypA on apoptosis: potential target for the treatment of diseases

Update on the Regulation and Maintenance of Epstein-Barr Virus Latency

A Proteomic Analysis of Nasopharyngeal Carcinoma in a Moroccan Subpopulation

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