The effects of CypA on apoptosis: potential target for the treatment of diseases

Chen, Li; Zeng, Zhuo; Luo, Haodang; Xiao, Hua; Zeng, Yanhua

doi:10.1007/s00253-023-12860-2

Cited by 1 publication

(1 citation statement)

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“…Modulation of apoptosis [ 66 ] and enhancement of proliferative cellular activity [ 67 ] can be considered as other important gero-protective effects of hypercapnia, including its combination with hypoxic exposure, shown in in vitro models on cultures of rat astrocytes and neurons, as well as in vivo in the peri-stroke area of the cerebral cortex. Under certain conditions, this mechanism may be the cause of malignant transformation of cells; however, in combination with the effective immune defense of the organism and reparative functions of the epigenomic apparatus of the cell, it may be a component of the strategy of protection against aging, especially of the brain and myocardium [ 68 , 69 ].…”

Section: Signaling Pathways Of the Gero-protective Potential Of Inter...mentioning

confidence: 99%

Relationship between Hypoxia and Hypercapnia Tolerance and Life Expectancy

Tregub,

Komleva,

Kulikov

et al. 2024

IJMS

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The review discusses the potential relationship between hypoxia resistance and longevity, the influence of carbon dioxide on the mechanisms of aging of the mammalian organism, and intermittent hypercapnic–hypoxic effects on the signaling pathways of aging mechanisms. In the article, we focused on the potential mechanisms of the gero-protective efficacy of carbon dioxide when combined with hypoxia. The review summarizes the possible influence of intermittent hypoxia and hypercapnia on aging processes in the nervous system. We considered the perspective variants of the application of hypercapnic–hypoxic influences for achieving active longevity and the prospects for the possibilities of developing hypercapnic–hypoxic training methods.

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