CYP3A4 Expression in Breast Cancer and its Association with Risk Factors in Mexican Women

Floriano-Sánchez, Esaú; Cárdenas-Rodríguez, Noemi; Bandala, Cindy; Coballase-Urrutía, Elvia; Lopez-Cruz, J.

doi:10.7314/apjcp.2014.15.8.3805

Cited by 31 publications

(32 citation statements)

References 29 publications

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“…Regarding the results of the current study, the most important barriers besides the barriers already discussed are: procrastination, embarrassment, long wait for getting an appointment, language barriers, and previous negative experiences that are indicated in various studies (Feng et al, 2014;Floriano et al, 2014). To surmount these barriers we recommend: identification of high risk women and their follow-up to prevent procrastination, providing private service places and appropriate time for service provision to solve the embarrassment problem, management of health service providers having the same language with people, providing the women with translators or teaching the native languages to the service providers to eliminate the language barriers, and presentation of good quality services and appropriate behavior with the patients to prevent negative screening experiences.…”

Section: Discussionmentioning

confidence: 81%

Breast Cancer Screening Barriers from the Womans Perspective: a Meta-synthesis

Azami-Aghdash¹,

Ghojazadeh²,

Sheyklo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: The principal aim of health service providers in the field of breast cancer is to detect and treat lesions at an appropriate time. Therefore, identification of barriers to screening can be very helpful. The present study aimed to systematically review the qualitative studies for extracting and reporting the barriers of screening for breast cancer from the womans perspective. Materials and Methods: In this systematic review; Pubmed, Google Scholar, Ovid Scopus, Cochrane Library, Iranmedex, and SID were searched using the keywords: screening barriers, cancer, qualitative studies, breast and their Persian equivalents, and the needed data were extracted and analyzed using an extraction table. To assess the quality of the studies, the Critical Appraisal Skills Programme (CASP) tool was used. Results: From 2,134 related articles that were found, 21 articles were eventually included in the study. The most important barriers from the point of view of 1,084 women were lack of knowledge, access barriers (financial, geographical, cultural), fear (of results and pain), performance of service providers, women's beliefs, procrastination of screening, embarrassment, long wait for getting an appointment, language problems, and previous negative experiences. Articles' assessment score was 68.9. Conclusions: Increasing women's knowledge, reducing the costs of screening services, cultural promotion for screening, presenting less painful methods, changing beliefs of health service providers, provision of privacy for giving service, decreasing the waiting time, and providing high quality services in a respectful manner can be effective ways to increase breast cancer screening.

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Section: Discussionmentioning

confidence: 81%

Breast Cancer Screening Barriers from the Womans Perspective: a Meta-synthesis

Azami-Aghdash¹,

Ghojazadeh²,

Sheyklo³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…While CYP2J2 does not appear to be widely expressed in breast cancer, CYP3A4 appears to be associated with breast cancer and widely expressed (Murray et al, 2010). CYP3A4 expression in breast cancer has also been recently associated with risk factors for breast cancer development and progression (Floriano-Sanchez et al, 2014) and is increased in breast tumors, but is also widely expressed in normal mammary tissue (Kapucuoglu et al, 2003). Breast cancer is also an admixture of malignant epithelia, stroma, blood vessels, and, not uncommonly, ductal carcinoma in situ (DICS).…”

Section: Introductionmentioning

confidence: 99%

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo

Sevrioukova

Denisov

et al. 2017

Cell Chemical Biology

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Summary The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport chain/respiration and inhibited AMPKα. CYP3A4 knockdown activated AMPKα, promoted autophagy, and prevented mammary tumor formation. The diabetes drug metformin inhibited CYP3A4-mediated EET biosynthesis and depleted cancer cell-intrinsic EETs. Metformin bound to the active site heme of CYP3A4 in a co-crystal structure, establishing CYP3A4 as a biguanide target. Structure-based design led to discovery of N1-hexyl-N5-benzyl-biguanide (HBB), which bound to the CYP3A4 heme with higher affinity than metformin. HBB potently and specifically inhibited CYP3A4 AA epoxygenase activity. HBB also inhibited growth of established ER+ mammary tumors and suppressed intratumoral mTOR. CYP3A4 AA epoxygenase inhibition by biguanides thus demonstrates convergence between eicosanoid activity in mitochondria and biguanide action in cancer, opening a new avenue for cancer drug discovery.

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“…In a study on Mexican patients with breast cancer, significant CYP3A4 overexpression was found in breast cancer stroma and gland regions in comparison with healthy tissue [80]. Similarly, studies have also observed CYP3A4 overexpression in tumor breast tissue when compared to normal tissues [81,82].…”

Section: Breast Cancermentioning

confidence: 92%