CYP2E1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan

Hildesheim, Allan; Anderson, Lucy M.; Chen, Chien-Jen; Cheng, Yiping; Brinton, Louise A.; Daly, Ann K.; Reed, Casie; Chen, I-How; Caporaso, Neil E.; Hsu, Mow‐Ming; Chen, Jen‐Yang; Idle, Jeffrey R.; Hoover, Robert N.; Yang, Czau‐Siung; Chhabra, Saranjit K.

doi:10.1093/jnci/89.16.1207

Cited by 191 publications

(144 citation statements)

References 31 publications

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“…Although the literature remains controversial, it has been reported that alterations of GSTM1 and CYP2E1 are associated with a moderate increased risk of NPC [28,29].…”

Section: Gstm1 and Cyp2e1 Polymorphismsmentioning

confidence: 99%

An Update on Epstein-Barr Virus and Nasopharyngeal Carcinogenesis

Perez-Ordoñez

2007

Head and Neck Pathol

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“…Although the literature remains controversial, it has been reported that alterations of GSTM1 and CYP2E1 are associated with a moderate increased risk of NPC [28,29].…”

Section: Gstm1 and Cyp2e1 Polymorphismsmentioning

confidence: 99%

An Update on Epstein-Barr Virus and Nasopharyngeal Carcinogenesis

Perez-Ordoñez

2007

Head and Neck Pathol

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“…Commonly suspected risk factors for NPC include Epstein-Barr virus (EBV) infection, environmental factors, and genetic susceptibility. Associations between NPC risk and certain genetic variations, such as polymorphisms in the CYP2E1 (Hildesheim et al, 1995;Jia et al, 2009) and HLA genes (Tse et al, 2009;Bei et al, 2010), have been suggested by previous studies. EBV has been identified consistently as an important risk factor and in patients with nasopharyngeal carcinoma from regions of high and low incidence, with a dose-response relationship between the EBV antibody level and NPC risk (Chen et al, 1985;Wei and Sham, 2005;Chang and Adami, 2006;Han et al, 2012;Tsao et al, 2014).…”

Section: Discussionmentioning

confidence: 75%

Time Trends of Nasopharyngeal Carcinoma in Urban Guangzhou over a 12-Year Period (2000-2011): Declines in Both Incidence and Mortality

Lin²,

Shen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Nasopharyngeal carcinoma (NPC) is an uncommon disease in most countries but occurs with much greater frequency in southern China. This study aimed to examine the secular trends of NPC in urban Guangzhou over the time period of 2000-2011 using data from the Guangzhou Cancer Registry. Age-adjusted annual incidence rates of NPC were calculated by the direct method using the WHO World Standard Population (1960) as the reference. The average annual percentage change (AAPC) was used as an estimate of the trend. A total of 7,532 new cases of NPC and 3,449 related deaths were registered. In both genders, the peak incidence occurred in the 50-to 59-year age group, and this age distribution pattern remained similar throughout. The AAPC in NPC incidence rates was -3.26% (95% CI: -5.4%--1.1) for males and -5.74% (95% CI: -8.9%--2.5) for females, resulting in a total decrease of 39.3% (from 22.14 to 13.44 per 100,000 population) for males and 48.6% (from 10.1 to 5.18 per 100,000 population) for females over this 12-year period. The AAPCs in NPC mortality rates were -4.62% (95%CI: -3.5%--5.7) for males and -6.75% (95% CI: -5.2%--8.3) for females, resulting in a total decrease of -46.1% (from 12.1 to 6.54 per 100,000 population) for males and 51.7% (from 4.14 to 2.00 per 100,000 population) for females. The age-adjusted incidence and mortality rates of NPC declined during 2000-2011 in urban Guangzhou but remained high. Future efforts to improve prevention, early detection and treatment strategies are needed.

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“…CYP2E1 may be less efficiently expressed among carriers of the c2 mutation, making them less susceptible to xenobiotic bioactivation (64). Examination of CYP2E1 variants in nasopharyngeal cancer cases and controls showed an RFLP distribution similar to the Japanese population but higher than in the Finnish or Swedish population (67). A 5-to 7.7-fold increase in cancer risk was found in subjects homozygous for these CYP2E1 variants.…”

Section: Analysis Of Variability and Susceptibilitymentioning

confidence: 65%

Human variability and susceptibility to trichloroethylene.

Pastino

Yap

Carroquino

2000

Environ Health Perspect

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Although humans vary in their response to chemicals, comprehensive measures of susceptibility have generally not been incorporated into human risk assessment. The U.S. EPA dose-response-based risk assessments for cancer and the RfD/RfC (reference dose-reference concentration) approach for noncancer risk assessments are assumed to protect vulnerable human subgroups. However, these approaches generally rely on default assumptions and do not consider the specific biological basis for potential susceptibility to a given toxicant. In an effort to focus more explicitly on this issue, this article addresses biological factors that may affect human variability and susceptibility to trichloroethylene (TCE), a widely used halogenated industrial solvent. In response to Executive Order 13045, which requires federal agencies to make protection of children a high priority in implementing their policies and to take special risks to children into account when developing standards, this article examines factors that may affect risk of exposure to TCE in children. The influence of genetics, sex, altered health state, coexposure to alcohol, and enzyme induction on TCE toxicity are also examined.

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CYP2E1 Genetic Polymorphisms and Risk of Nasopharyngeal Carcinoma in Taiwan

Abstract: Our findings suggest that the CYP2E1 genotype is a determinant of nasopharyngeal carcinoma risk.

Cited by 191 publications

References 31 publications

An Update on Epstein-Barr Virus and Nasopharyngeal Carcinogenesis

An Update on Epstein-Barr Virus and Nasopharyngeal Carcinogenesis

Time Trends of Nasopharyngeal Carcinoma in Urban Guangzhou over a 12-Year Period (2000-2011): Declines in Both Incidence and Mortality

Human variability and susceptibility to trichloroethylene.

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