CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study

Salinero, Juan José; Lara, Beatriz; Ruiz-Vicente, Diana; Areces, Francisco; Puente-Torres, Carlos; Gallo-Salazar, César; Pascual, Teodoro; Coso, Juan Del

doi:10.3390/nu9030269

Cited by 61 publications

(98 citation statements)

References 39 publications

(74 reference statements)

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“…In a recent study of 19 basketball players, acute ingestion of 3 mg/kg of caffeine produced similar effects on vertical jump performance in individuals with the AA genotype and AC/CC genotypes [11]. These results are in accord with a study that utilized a 30-s Wingate sprint test, while improvement in peak and mean power output was noted following caffeine ingestion, the researchers did not find differences in responses between genotypes [12]. Based on the results of these two studies, it seems variations in the CYP1A2 genotype may not affect the ergogenic effects of caffeine ingestion on high-intensity exercise performance.…”

Section: Introductionsupporting

confidence: 54%

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Grgić

Pickering

Bishop

et al. 2020

Journal of the International Society of Sports Nutrition

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Background: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.Methods: Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test.Results: Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20-0.61; p < 0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27-0.85; p < 0.001 for all); (c) vertical jump height (ES: 0.15; p = 0.017); and (d) power output in the Wingate test (ES: 0.33-0.44; p < 0.05 for all). We did not find a significant genotype × caffeine interaction effect (pvalues ranged from 0.094 to 0.994) in any of the analyzed performance outcomes.Conclusions: Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences.

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Section: Introductionsupporting

confidence: 54%

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Grgić

Pickering

Bishop

et al. 2020

Journal of the International Society of Sports Nutrition

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“…However, although we were not able to conduct a comparison with similar studies in the sports branches under consideration, there are similarities in the literature in general. In other studies, in a comparison of the data related to the rs762551 polymorphism in endurance athletes, the results from the long-distance runners of our study group have strong similarities with the genotype data from the study of Soutward (2016) on athletes and the results of the study of Salinero et al (17).…”

Section: Distribution Of Cyp1a2 Gene Related To Caffeine Metabolism Isupporting

confidence: 81%

Determination of the Distribution of the rs2069514 and rs762551 Alleles of the Cyp1a2 Gene Related to Caffeine Metabolism in Professional Athletes

Yucesoy¹,

Kapıcı²,

Sercan³

et al. 2017

Eur J Biol

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The objective of this study is to investigate allele distributions of the rs2069514 and rs762551 polymorphisms of the CYP1A2 gene which affect caffeine metabolism in long-distance and short-distance runners in the Turkish population. 20 professional athletes in total were included in the study within the age range of 18-24, 10 of whom were long-distance (female, n=5; Male, n=5) and 10 of whom were short-distance (Female, n=5; Male, n=5) runners. DNA isolation from the athletes was performed from peripheral blood samples and genotyping was determined using the technique of Real Time-PCR. According to the obtained data, the ratio of individuals having AA (n=6), GG (n=9) and AG (n=5) genotype for the region of rs2069514 was found as 30%, 45% and 25% respectively. On the other hand, the ratio for AA (n=4), CC (n=9) and AC (n=7) genotypes in the region of rs762551 allele was determined as 20%, 45% and 35%. According to the results, no significant variance regarding gender was found for either of the different polymorphisms under study in long-distance and short-distance runners while the genotype distributions varied between short and long-distance runners only in the rs2069514 polymorphism. The GG genotype was observed in 9 short-distance runners while it was observed in none of the long-distance runners. As a result, the fact that the GG genotype in case of the Rs2069514 polymorphism was observed in nine of the ten short-distance runners suggests that the athletes in this group metabolize caffeine slowly and this should be considered in the caffeine intake.

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“…All these outcomes indicate that caffeine might be effective to increase performance in the 15‐s adapted version of the Wingate anaerobic test during the menstrual cycle. Measuring individual responses to caffeine should be conducted before caffeine is recommended as a substance to increase anaerobic performance in women, as it has been reported that some individuals do not positively respond to caffeine …”

Section: Discussionmentioning

confidence: 99%

“…Despite the initial controversy on this topic, the effectiveness of acute caffeine ingestion to improve peak and mean cycling power in the Wingate anaerobic performance test has been well established by recent investigations and meta‐analytic data . However, evidence also suggests that doses <3 mg of caffeine/kg of body mass or the use of coffee as the form caffeine administration might be less effective than the use of 3–9 mg/kg via pure anhydrous caffeine or caffeinated energy drinks . Caffeine ergogenicity for the Wingate test might persist with daily ingestion of 3 mg/kg of caffeine for 15–18 days; however, the magnitude of its ergogenic effect is higher the first day of ingestion, suggesting tolerance to this substance .…”

Section: Introductionmentioning

confidence: 99%

“…The above‐mentioned investigations have been carried out using samples of only male participants or women represented a low proportion of the study subjects, impeding a subanalysis of caffeine effects on female participants . The meta‐analysis of the caffeine ergogenic effect on Wingate performance carried out by Grgic 5 included 16 studies with 246 male participants and only 47 female participants.…”

Section: Introductionmentioning

confidence: 99%

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Acute caffeine intake increases performance in the 15‐s Wingate test during the menstrual cycle

Lara

Gutiérrez-Hellín

Ruíz-Moreno

et al. 2020

Brit J Clinical Pharma

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Aims In male athletes, caffeine is considered an ergogenic aid to increase anaerobic performance during the Wingate anaerobic test (WANT). However, information about the effect of caffeine on WANT performance in female athletes is contradictory. Furthermore, it is unknown whether the ergogenicity of caffeine is present during all the phases of the menstrual cycle. The aim of this study was to investigate the effects of caffeine intake on WANT performance during 3 phases of the menstrual cycle. Methods Thirteen well‐trained eumenorrhoeic triathletes participated in a double‐blind, placebo‐controlled, cross‐over experimental trial. On 2 different days in each phase, and in randomized order, participants ingested caffeine (3 mg kg−1) or a placebo (cellulose). The menstrual cycle phases were individually characterized as follows: (i) early follicular; (ii) preovulatory; and (iii) midluteal. In each trial, participants performed a 15‐s adapted version of the WANT. Results In comparison to the placebo, caffeine increased peak power during the WANT in the early follicular (8.6 ± 0.8 vs 8.9 ± 0.9 W/kg, P = .04; effect size [d] = 0.45), preovulatory (8.6 ± 0.9 vs 8.9 ± 0.9 W/kg, P = .04; d = 0.23) and mid‐luteal phases (8.6 ± 0.8 vs 8.9 ± 0.9 W/kg, P < .01; d = 0.52). Conclusion The ergogenic effect of caffeine on WANT peak cycling power was of a similar magnitude in the follicular, preovulatory, and mid‐luteal phases. These results suggest that caffeine increases performance in the 15‐s Wingate test in women athletes and it might be considered an ergogenic aid to increase anaerobic performance in eumenorrhoeic women during their menstrual cycle.

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CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study

Cited by 61 publications

References 39 publications

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Determination of the Distribution of the rs2069514 and rs762551 Alleles of the Cyp1a2 Gene Related to Caffeine Metabolism in Professional Athletes

Acute caffeine intake increases performance in the 15‐s Wingate test during the menstrual cycle

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