CYP1A2 genotype and acute effects of caffeine on resistance exercise, jumping, and sprinting performance

Abstract

Background: It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. The purpose of this study was to explore the acute effects of caffeine on resistance exercise, jumping, and sprinting performance in a sample of resistance-trained men, and to examine the influence of genetic variation of CYP1A2 (rs762551) on the individual variation in responses to caffeine ingestion.Methods: Twenty-two men were included as participants (AA homozygotes n = 13; C-allele carriers n = 9) and were tested after the ingestion of caffeine (3 mg/kg of body mass) and a placebo. Exercise performance was assessed with the following outcomes: (a) movement velocity and power output in the bench press exercise with loads of 25, 50, 75, and 90% of one-repetition maximum (1RM); (b) quality and quantity of performed repetitions in the bench press exercise performed to muscular failure with 85% 1RM; (c) vertical jump height in a countermovement jump test; and (d) power output in a Wingate test.Results: Compared to placebo, caffeine ingestion enhanced: (a) movement velocity and power output across all loads (effect size [ES]: 0.20-0.61; p < 0.05 for all); (b) the quality and quantity of performed repetitions with 85% of 1RM (ES: 0.27-0.85; p < 0.001 for all); (c) vertical jump height (ES: 0.15; p = 0.017); and (d) power output in the Wingate test (ES: 0.33-0.44; p < 0.05 for all). We did not find a significant genotype × caffeine interaction effect (pvalues ranged from 0.094 to 0.994) in any of the analyzed performance outcomes.Conclusions: Resistance-trained men may experience acute improvements in resistance exercise, jumping, and sprinting performance following the ingestion of caffeine. The comparisons of the effects of caffeine on exercise performance between individuals with the AA genotype and AC/CC genotypes found no significant differences.

Caffeine improves various aspects of athletic performance in adolescents independent of their 163 C > A CYP1A2 genotypes

“…17 Interestingly, a recent study found that CAF improves jump performance in resistance-trained men, but this improvement was independent of CYP1A2 genotypes. 36 Together, our findings and those in the reviewed literature indicate that CAF may be ergogenic for jump performance in some circumstances, but it seems to be independent of CYP1A2 genotype.…”

“…Contradictory findings in relation to the influence of CYP1A2 genotypes on CAF‐induced improvements in muscular endurance have been reported, with one study showing an increased number of repetitions (85% of 1RM performed until failure) after CAF ingestion only in AA homozygotes (n = 14) 14 . In another study, CAF improved muscular endurance to a similar degree in both AA homozygotes and C allele carriers 36 . No prior study has investigated the effect of CAF ingestion separately in AC and CC genotype, so our findings expand our understanding by showing that CAF improves muscular endurance in all three variants of the CYP1A2 polymorphism.…”

Effects of CYP1A2 and ADORA2A Genotypes on the Ergogenic Response to Caffeine in Professional Handball Players

“…In the current investigation, acute caffeine intake (3 mg•kg −1 •bm) was effective to increase jump height in a countermovement jump (+3.9%). This ergogenic effect of caffeine is a recurrent finding in the literature as several investigations have found an effect of similar magnitude in basketball players [11], volleyball players [49], swimmers [13], and resistance-trained individuals [31]. Acute caffeine intake was also ergogenic to enhance sprint performance as it reduced the time to complete a 30-m sprint test (−2.6%).…”

“…However, to date, findings have been controversial, with some studies reporting a higher response to caffeine in AA athletes [22,29] and other studies showing a better response to caffeine in C-carrier athletes [30]. Overall, most of the investigations have found that the ergogenic response to caffeine is independent of the CYP1A2 −163 C > A polymorphism [11,23,24,[31][32][33][34][35][36].…”

Caffeine and Exercise Performance: Possible Directions for Definitive Findings

“…The results indicate that the caffeine intake increased the peak power (±682 W vs. ±667 W; p = 0.008) and the mean power during the Wingate test (±527 W vs. ±518 W; p < 0.001) without differences between A/A genotype and C-allele carriers (p > 0.05). These appointments were again confirmed by Grgic et al (2020b) using the same dosage of caffeine (3 mg.kg −1 ) in the morning before the Wingate test. Thus, there is no evidence that different genotyping for CYP1A2 can mediate increased performance from caffeine use in short duration, high-intensity exercises, at least in the doses used (3-6 mg.kg −1 ).…”