CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: Study of population from a high- incidence area in north China

Wang, Lidong; Zheng, Shusen; Liu, Bin; Zhou, Jianrong; Li, Yanjie; Li, Jixue

doi:10.3748/wjg.v9.i7.1394

Cited by 55 publications

(47 citation statements)

References 14 publications

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“…No results have been thus far reported for association between EPHX1 activity and gastric cancer. Interestingly, a marked decreased risk for slow EPHX1 activity has been often observed for respiratory tumors strongly related to smoking, such as lung (35) and larynx (36), whereas an increased risk for slow activity has been reported for digestive tumors, such as esophagus (37) and colorectal adenoma (38), the latter was significant only among smokers.…”

Section: Discussionmentioning

confidence: 96%

“…36 Metabolic gene allele nomenclature according to that recommended by Garte et al (11) is also provided. 37 Other Factors. Subjects were classified according to smoking habit at recruitment as current, former, or never smokers of any type of tobacco products, although the majority of them smoked cigarettes exclusively or in addition to cigars and/or pipe.…”

Section: Methodsmentioning

confidence: 99%

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Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Agudo¹,

Sala

Pera³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Metabolizing enzymes, which often display genetic polymorphisms, are involved in the activation of compounds present in tobacco smoke that may be relevant to gastric carcinogenesis. We report the results of a study looking at the association between risk of gastric adenocarcinoma and polymorphisms in genes CYP1A1, CYP1A2, EPHX1, and GSTT1. A nested case-control study was carried out within the European Prospective Investigation into Cancer and Nutrition, developed in 10 European countries. The study includes 243 newly diagnosed cases of histologically confirmed gastric adenocarcinoma and 946 controls matched by center, age, sex, and date of blood collection. Genotypes were determined in nuclear DNA from WBCs. We found an increased risk of gastric cancer for homozygotes for C (histidine) variant in Y113H of EPHX1 (odds ratio, 1.91; 95% confidence interval, 1.19-3.07) compared with subjects with TC/TT. There was also a significant increased risk for smokers carrying at least one variant allele A in Ex7+129C>A (m4) of CYP1A1 and never smokers with null GSTT1 and allele A in the locus À3859G>A of CYP1A2. Most of these genes are involved in the activation and detoxification of polycyclic aromatic hydrocarbons, suggesting a potential role of these compounds in gastric carcinogenesis. (Cancer Epidemiol Biomarkers Prev

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Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Agudo¹,

Sala

Pera³

et al. 2006

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…In contrast, Wang et al (2003) found cases with CYP1A1 Ile/Val polymorphism had no significant difference of developing esophageal squamous cell carcinoma compared to controls in Northern China. A study of Wang et al (2002a) .…”

Section: Discussionmentioning

confidence: 51%

“…Guo et al (2005) found that individuals with the MspI T/C or C/C genotype had a higher risk of developing esophageal cancer than those with the T/T genotype (OR:1.93,95%CI:1.01-3.84). However, the study results of Wang et al (2003) suggested that the genotype of MspI T/C (OR:0.41,95%CI:0.17-0.99) or (T/C+C/C) (OR:0.41,95%CI:0.17-0.99) might be protective factor for developing esophageal cancer. The heterozygosis genotype T/C of CYP1A1 MspI genetic polymorphism was found to be associated with elevated esophageal cancer risk in the study of van Lieshout et al (1999).…”

Section: Discussionmentioning

confidence: 88%

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CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

Yun

Wang

et al. 2013

Asian Pacific Journal of Cancer Prevention

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The purpose of this study was to evaluate the associations of CYP1A1 genetic polymorphisms with the risk of developing esophageal cancer (EC). A case-control study was carried out in a Chinese population in which 157 hospital based EC cases and 157 population based healthy controls with 1:1 match by age and sex were included. PCR based restriction fragment length polymorphisms (PCR-RFLP) were used to detect genotypes in case and control groups.

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Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children

Silveira

Canalle

Scrideli

et al. 2009

Environ and Mol Mutagen

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Polymorphic variations of several genes associated with dietary effects and exposure to environmental carcinogens may influence susceptibility to leukemia development. The objective of the present study was to evaluate the effect of the polymorphisms of debrisoquine hydroxylase (CYP2D6), epoxide hydrolase (EPHX1), myeloperoxidase (MPO), and quinone-oxoreductase (NQO1), which have been implicated in xenobiotic metabolism, on the risk of childhood acute lymphoblastic leukemia (ALL). We evaluated the frequency of polymorphisms in the CYP2D6 (*3 and *4), EPHX1 (*2 and *3), MPO (*2), and NQO1 (*2) genes in 206 patients with childhood ALL and in 364 healthy individuals matched for age and gender from a Brazilian population separated by ethnicity (European ancestry and African ancestry), using the PCR-RFLP method. The CYP2D6 polymorphism variants were associated with an increased risk of ALL. The EPHX1, NQO1, and MPO variant genotypes were significantly associated with a reduced risk of childhood ALL. A significantly stronger protective effect is observed when the EPHX1, NQO1, and MPO variant genotypes are combined suggesting that, CYP2D6 polymorphisms may play a role in the susceptibility to pediatric ALL, whereas the EPHX1, NQO1, and MPO polymorphisms might have a protective function against leukemogenesis.

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CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: Study of population from a high- incidence area in north China

Cited by 55 publications

References 14 publications

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

Polymorphisms in Metabolic Genes Related to Tobacco Smoke and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition

CYP1A1 Genetic Polymorphisms and Risk for Esophageal Cancer: a Case-control Study in Central China

Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children

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