CYP1A1 CYP2E1 and GSTM1 polymorphisms are not associated with susceptibility to squamous-cell carcinoma of the esophagus

Abstract

We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n 5 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms. There were no significant differences in the frequency distribution of any one of the 3 polymorphisms between esophageal cancer patients and 132 healthy Japanese controls. The genotype distributions in tobacco smokers or alcohol drinkers were also quite similar for male patients and male controls. The age at onset of esophageal cancer was also similar for patients with any genotype of the 3 polymorphisms. We conclude that the 3 polymorphisms are unlikely to be associated with esophageal cancer susceptibility. Int.

Genetic polymorphisms of cytochrome P4501A1 and oesophageal squamous-cell carcinoma in Taiwan

“…In contrast, the CYP1A1 MspI genetic polymorphism was not found to be associated with elevated oesophageal cancer risk. Several studies on ethnic Japanese populations reported no association between CYP1A1 MspI and exon 7 polymorphisms and risk of oesophageal cancer (Hori et al, 1997;Morita et al, 1997;van Lieshout et al, 1999). However, their small case popula- CYP1A1 and oesophageal cancer M-T Wu et al tion (less than 100 oesophageal cancer cases were investigated) may not be sufficient to make a scientific determination regarding genotype significance.…”

“…Previous studies have suggested that variant alleles of CYP1A1 MspI polymorphism are associated with malignancies, particularly lung cancer (Kawarjiri et al, 1990;Nakachi et al, 1991;Hayashi et al, 1992;Xu et al, 1996). As reported by Bartsch et al (2000), no association was identified between CYP1A1 MspI and exon 7 polymorphisms and oesophageal cancer risk in a series of studies done on populations of Caucasians and Japanese (Lucas et al, 1996;Hori et al, 1997;Morita et al, 1997;van Lieshout et al, 1999). However, Nimura et al (1997) studied 89 oesophageal carcinoma patients and 137 cancer-free control patients in an ethnically Chinese population and reported that heavy smokers with Val/Val genotypes of CYP1A1 exon 7 had a three-fold risk of developing oesophageal cancer as compared to those with Ile/Ile genotypes.…”

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

“…Increased risk of oral (Hung et al, 1997), nasopharyngeal (Hildesheim et al, 1997) and liver (Ladero et al, 1996) cancers were observed in rare genotype or allele carriers in another few studies. However, many other studies did not find any significant association between the CYP2E1 polymorphisms and cancer risks of the oral cavity and pharynx (Matthias et al, 1998), oesophagus (Morita et al, 1997), stomach (Kato et al, 1995;Nishimoto et al, 2000), lung (Kato et al, 1992;Hirvonen et al, 1993;London et al, 1993;Persson et al, 1993), and bladder (Anwar et al, 1996).…”

Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer

“…Individuals with the CYP2E1*c1*c1 genotype possessed a much greater risk of developing ESCC compared with those carrying the CYP2E1*c2 allele among Chinese drinkers; Furthermore, CYP2E1*c1*c1 exhibits a synergistic interaction with ALDH2*1*2 and methylenetetrahydrofolate reductase (MTHFR)677 (C/T+T/T) (62,63). However, in several cases, particularly in Caucasians, gene polymorphisms of CYP2E1 have no association with esophageal cancer (64)(65)(66)(67).…”