Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule

Bayala, Bagora; Bassolé, Imaël Henri Nestor; Maqdasy, Salwan; Baron, Silvère; Simporé, Jacques; Lobaccaro, Jean-Marc A.

doi:10.1016/j.biochi.2018.02.013

Cited by 76 publications

(52 citation statements)

References 33 publications

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“…We did not test for cytotoxicity at these concentrations but there are no reports of cytotoxicity of these concentrations in somatic cells. In terms of selectivity, a number of studies have shown that non-cancer cells are less sensitive to plant extracts than tumor cell lines, which can be explained by the growth rate of tumor cells compared with non-cancer cells [25]. In addition, a toxicity study suggested that myricetin, a compound present in L. apiculata extract, does not exert cytotoxicity towards normal breast epithelial MCF10A cells, hence, researchers concluded that the compound is safe for further in vivo studies [26].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of Luma apiculata against resistant strains of Staphylococcus aureus and Klebsiella pneumoniae

Treulén¹,

Salcedo

Paz

et al. 2019

PAB

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Bacterial resistance is the mechanism through which the bacteria can decrease the action of antimicrobial agents. Studies have reported an antimicrobial action of Luma apiculata, however, there are no in vitro studies demonstrating the effect of this plant against multidrug-resistant bacteria. The objective of this study was to explore the antimicrobial properties of alcoholic extract of Luma apiculata against standard multi-resistant bacterial pathogens. Multidrug-resistant strains of Staphylococcus aureus ATCC 43300 (MRSA) and Klebsiella pneumoniae ATCC BAA 1705 (CRKP) were incubated independently for 72 h at 37ºC with different concentrations (1-10,000 µg/mL) of alcoholic extract of Luma apiculata. The growth curve was studied up to 72 hours. The minimum inhibitory concentration (MIC) was determined by broth macrodilution method. The agar diffusion method was used to examine bacteriostatic activity and bactericidal activity was evaluated by a commercial kit and analyzed by flow cytometry. Analyses of chromatographic data, as well as mass spectrometry, were performed to determine the main compounds present in the extracts. Luma apiculata leaves extracts showed bactericidal activity and was effective attenuating growth in both bacterial strains. Thus, Luma apiculata could represent a natural alternative against multidrug-resistant bacterial strains. However, further studies should be undertaken to test their clinical utility.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of Luma apiculata against resistant strains of Staphylococcus aureus and Klebsiella pneumoniae

Treulén¹,

Salcedo

Paz

et al. 2019

PAB

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“…JAMUNA et al (2017) assessed the scavenging activity of the essential oil from C. citratus against DPPH and observed that the highest essential oil concentration (100g ml -1 ) led to better DPPH scavenging activity than other concentration levels. BAYALA et al (2018) observed the antioxidant activity of C. citratus scavenging DPPH and recorded 67.58% inhibition at 8mg mL -1 . REYES-SOLANO (2017) analyzed the essential oil from L. alba and reported IC 50 =12.45mg mL -1 in the DPPH assay.…”

Section: Antioxidant Activitymentioning

confidence: 94%

Antioxidant activity of essential oils from condiment plants and their effect on lactic cultures and pathogenic bacteria

et al. 2019

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Studies about preservative and antioxidant activity of essential oils have been encouraged in recent years, given their importance to food industry. The aim of the current study was to evaluate the antioxidant properties and antimicrobial activity of essential oils deriving from Syzygium aromaticum, Cymbopogon citratus and Lippia alba against lactic and pathogenic bacteria responsible for food-borne diseases. Essential oil antibacterial activity was assessed through disc diffusion and macrodilution tests conducted in a mixed lactic culture of Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus (YF-L903) and of Escherichia coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), Salmonella enterica (ATCC 6017) strains. Based on the chromatographic analysis results, the essential oils shown to be composed of eugenol (79.41%) which was the prevalent compound in S. aromaticum, geranial (31.89%), neral (24.52%) and β-myrcene (25.37%) in C. citratus, as well as of geranial (33.80%) and neral (25.63%) in L. alba. The observed antibacterial activity confirmed the dose-dependent effect of these three oils on all the assessed bacteria; there was halo inhibition at concentration 20μL mL-1. The essential oil of S. aromaticum presented better antioxidant activity, with IC50 equal to 5.76μg mL-1 and antioxidant activity index of 6.94, and it was considered strong (AAI>2.0) in comparison to the other evaluated oils. This essential oil also presented excellent antioxidant activity at concentrations lower than the one required to inhibit lactic cultures. Based in this outcome, the essential oil from S. aromaticum can be used as preservative agent in processed food whose formulation presents lactic cultures.

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“…Aussi le limonène (6,4%), un monoterpène hydrocarboné de l'huile, contribuerait à l'amélioration de l'activité antioxydante car il est un antistress significatif, à actions mesurables par des paramètres comportementaux et physiologiques, sous l'influence du système nerveux (Alessio et al, 2014). L'activité de l'huile essentielle de Cymbopogon citratus, s'expliquerait aussi par la présence d'aldéhydes et d'alcools (citral constituant majoritaire, géraniol...), qui utilisent divers mécanismes dans le processus de désactivation des radicaux (Bayala et al, 2018). L'activité antioxydante de nos huiles est plus faible que celle de l'acide ascorbique, composé de référence (CI50 = 20 µg/mL).…”

Section: Activité Antioxydante Des Huiles Essentiellesunclassified

Relations entre composition chimique, activité antioxydante et toxicité des huiles essentielles de deux espèces de <i>Cymbopogon</i> acclimatées au Bénin

Kpadonou¹,

Allanto²,

Kpadonou-Kpoviessi³

et al. 2019

Int. J. Bio. Chem. Sci

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Les plantes aromatiques jouent un rôle considérable dans plusieurs secteurs notamment dans la médicine traditionnelle. Dans le but de la valorisation de ces plantes, ce travail a pour objectif d'évaluer la relation composition chimique-activité antioxydante, et la toxicité des huiles essentielles de Cymbopogon citratus et Cymbopogon schoenantus acclimatées au Bénin. Les huiles essentielles (HE) ont été obtenues et analysées par CPG/DIF et CPG/SM. Le test antioxydant a été réalisé par la méthode de DPPH et celui de la toxicité sur les larves de crevette de Artémia salina Leach. L'analyse chimique a révélé plusieurs composés dont le citral à 75% dans l'HE de Cymbopogon citratus et la pipéritone à 60,3% dans celle de Cymbopogon schoenantus. L'activité antioxydante varie d'une plante à une autre avec l'huile de Cymbopogon schoenantus (CE50 = 5040 µg/mL) plus antioxydante que celle de Cymbopogon citratus (CE50 = 47860 µg/mL). Cette activité de l'huile de Cymbopogon schoenantus pourrait s'expliquer par la présence de constituants comme la pipéritone et le limonène, reconnus pour leurs propriétés antioxydantes. Toutes les huiles étudiées sont moins antioxydantes que le composé de référence (acide ascorbique; CE50 = 20 µg/mL), et moins toxiques (CL50 ˃30 µg/mL) que la camptothécine (CL50 = 13,27 µg/mL). Ces huiles essentielles, moins toxiques et déjà utilisées dans la médicine traditionnelle, pourraient également contribuer à la prise en charge des maladies dues aux radicaux libres.

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Cymbopogon citratus and Cymbopogon giganteus essential oils have cytotoxic effects on tumor cell cultures. Identification of citral as a new putative anti-proliferative molecule

Cited by 76 publications

References 33 publications

Antimicrobial activity of Luma apiculata against resistant strains of Staphylococcus aureus and Klebsiella pneumoniae

Antimicrobial activity of Luma apiculata against resistant strains of Staphylococcus aureus and Klebsiella pneumoniae

Antioxidant activity of essential oils from condiment plants and their effect on lactic cultures and pathogenic bacteria

Relations entre composition chimique, activité antioxydante et toxicité des huiles essentielles de deux espèces de <i>Cymbopogon</i> acclimatées au Bénin

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