Cylindroxanthones A–C, three new xanthones and their cytotoxicity from the stem bark of Garcinia cylindrocarpa

Sukandar, Edwin Risky; Ersam, Taslim; Fatmawati, Sri; Siripong, Pongpun; Aree, Thammarat; Tip‐pyang, Santi

doi:10.1016/j.fitote.2015.11.017

Cited by 21 publications

(27 citation statements)

References 17 publications

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“…These results suggest the presence of phenolic compounds could be major contributor to antioxidant activity. The phenolic compounds including xanthone [37] or stilbene [38] have been reported as a potent antioxidant activity. Based on this study, the phenolic compounds of C. odorata could be extracted by the polar and semipolar solvents very well.…”

Section: Discussionmentioning

confidence: 99%

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

Putri

Fatmawati

2019

Evidence-Based Complementary and Alternative Medicine

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Chromolaena odorata L. (Asteraceae) is one of the tropical plants which is widely used as traditional medicines for diabetes and soft tissue wounds treatment in some regions in East Indonesia. The present study was aimed at determining the bioactive compounds of C. odorata leaves. The methanol and ethyl acetate extracts of C. odorata leaves have the inhibitory activity against 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and 2,2’-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals as well as α-glucosidase rat intestine enzyme. A new flavanone was isolated from the methanol extract and elucidated as 5,3’-dihydroxy-7,6’-dimethoxyflavanone or, namely, odoratenin (1) together with two known compounds: isosakuranetin (2) and subscandenin (3). The antioxidant activity of odoratenin (1) exhibited very potent ABTS radical inhibitory activity with IC50 value of 23.74 μM which is lower than that of trolox (IC50 31.32 μM) as a positive control. The result showed that a new flavanone, odoratenin (1), should be potential as an antioxidant source.

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Section: Discussionmentioning

confidence: 99%

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

Putri

Fatmawati

2019

Evidence-Based Complementary and Alternative Medicine

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“…Cylindroxanthones A–C ( 34 , 35 and 36 ) ( Figure 3 ) were gained from G. cylindrocarpa [ 180 ], along with the increase of methoxy, the anti-proliferative potency against oral epidermoid KB cell line (IC 50 : 2.36, 59.05 and 57.24 μM for 34 , 35 and 36 respectively) increased. The results indicated that the oxidation of the unsaturated isoprenyl group reduced anti-proliferative activity.…”

Section: Bioactivities Of Xanthonesmentioning

confidence: 99%

Chemical and Biological Research on Herbal Medicines Rich in Xanthones

Ruan¹,

Zheng²,

Liu³

et al. 2017

Molecules

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Xanthones, as some of the most active components and widely distributed in various herb medicines, have drawn more and more attention in recent years. So far, 168 species of herbal plants belong to 58 genera, 24 families have been reported to contain xanthones. Among them, Calophyllum, Cratoxylum, Cudrania, Garcinia, Gentiana, Hypericum and Swertia genera are plant resources with great development prospect. This paper summarizes the plant resources, bioactivity and the structure-activity relationships (SARs) of xanthones from references published over the last few decades, which may be useful for new drug research and development on xanthones.

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“…[4][5] The medicinal properties of traditional medicinal plants have been investigated in the recent scientific developments for treatment of many metabolic diseases. The extract of these plants from various places in the world are reported to possess several pharmacological activities including anti-inflammatory, [6][7] antidiabetic, [8][9][10][11] antimalarial, 12 antimicrobial, [13][14] anti TB, 15 anthelmintic activity, 16 anticancer, [17][18] cylindroxanthones A-C (1-3 etc. Traditional medicinal plants derived natural product such as alkaloids, flavonoids and terpenes.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Capacity of Some Selected Medicinal Plants in East Nusa Tenggara, Indonesia: The Potential of Sterculia quadrifida R.Br.

Lulan¹,

Fatmawati

Santoso

et al. 2018

FRA

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Background:Medicinal plants derived natural product such as alkaloids, flavonoids and terpenes. The traditional uses claim that medicinal plants of NTT are potential folk medicine but very little research has been conducted on these plants. Objective: The present study is directed towards evaluating naturally effective antioxidant of twenty-four traditional medicinal plants collected from Kupang, East Nusa Tenggara (NTT) using in vitro models. Method: The antioxidant activities were determined by using the free radical scavenging assays 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2-2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS). Analysis of total flavonoid and phenolic contents were expressed as Quercetin Equivalent (QE) and Gallic Acid Equivalent (GAE), respectively. Statistical methods are used in data analysis include mean or standard deviation, and regression analysis. Result: Methanol extract of Sterculia quadrifida R. Br. root exhibited the highest DPPH radical scavenging activity with IC 50 value of 3.11μg/mL, followed by Schleichera oleosa and Euphorbia hirta L. extracts with IC 50 values of 10.05 and 10.09 μg/mL, respectively. Methanol extract of S. quadrifida also showed highest ABTS radical scavenging activity with IC 50 value of 7.29 μg/mL, followed by Eugenia jambolana Lam. and Lamea grandus with IC 50 value of 9.15 and 12.29 μg/mL, respectively. S. quadrifida extract showed high flavonoid and phenolic content with 661.85 mg of GAE and 116.84 mg of QE per 100 g of extracts. Conclusion: The present study gives scientific evidences that twenty four samples of NTT plants have high free radical scavenging capacity. Strong radical scavenging activity of these plants especially S. quadrifida could be considered as a potential source of natural antioxidants.

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Cylindroxanthones A–C, three new xanthones and their cytotoxicity from the stem bark of Garcinia cylindrocarpa

Cited by 21 publications

References 17 publications

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

A New Flavanone as a Potent Antioxidant Isolated from Chromolaena odorata L. Leaves

Chemical and Biological Research on Herbal Medicines Rich in Xanthones

Antioxidant Capacity of Some Selected Medicinal Plants in East Nusa Tenggara, Indonesia: The Potential of Sterculia quadrifida R.Br.

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