Cylindrospermopsin induces neurotoxicity in tilapia fish (Oreochromis niloticus) exposed to Aphanizomenon ovalisporum

Guzmán-Guillén, Remedios; Manzano, Inmaculada Lomares; Moreno, Isabel; Prieto, Ana I.; Moyano, Rosario; Blanco, Alfonso; Cameán, Ana M.

doi:10.1016/j.aquatox.2015.01.024

Cited by 49 publications

(40 citation statements)

References 52 publications

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“…CYN is cytotoxic, hepatoxic, neurotoxic, genotoxic and possibly induces carcinogenic effects [7,8]. The identification of CYN as a human health hazard was first noticed in an incident which occurred in Palm Island, Australia (1979); the illness included headache, fever, anorexia, vomiting, abdominal pain, constipation and hepatomegaly [1].…”

Section: Introductionmentioning

confidence: 99%

Influence of Cooking (Microwaving and Broiling) on Cylindrospermopsin Concentration in Muscle of Nile Tilapia (Oreochromis niloticus) and Characterization of Decomposition Products

Prieto

Guzmán-Guillén

Valderrama-Fernández

et al. 2017

Toxins

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Cylindrospermopsin (CYN) has become increasingly important as a freshwater algal toxin, showing cytotoxic effects. This toxin is able to bioaccumulate in freshwater food webs, representing a serious human health problem. Normally, fish is cooked before consumption, and CYN concentration can be altered. For the first time, the effects of microwaving and broiling for 1 and 2 min on CYN concentration and its decomposition products in fish muscle (Oreochromis niloticus) contaminated in the laboratory were investigated, using UPLC-MS/MS and Orbitrap. The results show that cooking the fish reduced unconjugated CYN levels by 11, 10 and 15% after microwaving for 1 and 2 min, and broiling for 2 min, respectively, compared to control fish. Different CYN decomposition products with m/z 416.1234 (7-epi-CYN) and m/z 336.16663 (diasteroisomers C-3A, C-3C, C-3D, C-3E, C-3F) are generated in fish samples submitted to cooking. Based on the relative abundance of the decomposition products, the possible degradation pathways taking place by microwaving may be through the formation of 7-epi-CYN and m/z 336.16663 compounds, whereas in the case of broiling the last route is the only one observed in this study. The influence of cooking and the toxicity characterization of the degradation products generated in CYN-contaminated fish are of importance for more realistic risk evaluation related to their consumption.

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Section: Introductionmentioning

confidence: 99%

Influence of Cooking (Microwaving and Broiling) on Cylindrospermopsin Concentration in Muscle of Nile Tilapia (Oreochromis niloticus) and Characterization of Decomposition Products

Prieto

Guzmán-Guillén

Valderrama-Fernández

et al. 2017

Toxins

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“…Liver and kidney have been described as the main target organs of this toxin in vivo. However, its toxic effects have also been found in other organs, such as heart, stomach, thymus, spleen, lungs, ovaries, and brain [8,130]. Moreover, in vitro studies carried out in various mammalian cell lines have reported disruption of cell growth or cytotoxicity [129,131,132,133,134].…”

Section: Cylindrospermopsinmentioning

confidence: 99%

“…Taking into account the protection offered by Trolox (vitamin E) in MC intoxications, Guzmán-Guillén et al [8] were pioneers in evaluating the protection offered by this chemoprotectant (700 mg vitamin E/kg bw/day, or 25 mg/fish/day, for 7 days) on the effects produced in liver and kidney of tilapia by acute exposure to CYN (Table 1 and Table 3). Changes induced in almost every oxidative stress biomarker were prevented by vitamin E supplementation in both organs studied, except in SOD activity, which was not prevented in kidney of pretreated, intoxicated fish (Table 3).…”

Section: Cylindrospermopsinmentioning

confidence: 99%

“…The resulting toxic effects are widely described in the scientific literature. These toxins have been shown to induce histopathological effects [3,4,5], genotoxicity [6,7], neurotoxicity [8,9], developmental toxicity [10,11,12], reproductive toxicity [13,14], etc. In this regard, Buratti et al [15] recently reviewed the most relevant aspects (producing organisms, biosynthesis/genetics and occurrence, toxicological profile) of various cyanotoxins, including MCs and CYN.…”

Section: Introductionmentioning

confidence: 99%

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Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review

Guzmán-Guillén

Puerto

Gutiérrez-Praena

et al. 2017

Toxins

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Cyanobacterial toxins, particularly microcystins (MCs) and cylindrospermopsin (CYN), are responsible for toxic effects in humans and wildlife. In order to counteract or prevent their toxicity, various strategies have been followed, such as the potential application of chemoprotectants. A review of the main substances evaluated for this aim, as well as the doses and their influence on cyanotoxin-induced toxicity, has been performed. A search of the literature shows that research on MCs is much more abundant than research on CYN. Among chemoprotectants, antioxidant compounds are the most extensively studied, probably because it is well known that oxidative stress is one of the toxic mechanisms common to both toxins. In this group, vitamin E seems to have the strongest protectant effect for both cyanotoxins. Transport inhibitors have also been studied in the case of MCs, as CYN cellular uptake is not yet fully elucidated. Further research is needed because systematic studies are lacking. Moreover, more realistic exposure scenarios, including cyanotoxin mixtures and the concomitant use of chemoprotectants, should be considered.

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“…Some species can produce hepatotoxic and neurotoxic, such as aphantoxin, anatoxin-a, cylindrospermopsin, and saxitoxin, cyanobacterial secondary metabolites which can cause critical problems (Paerl and Huisman 2009;Ballot et al 2010;Zhang et al 2015). Therefore, it is very important for the accurate species identification of Aphanizomenon because of water bloom with several toxin-producing species (Guzmán-Guillén et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Morphology and taxonomy of the Aphanizomenon spp. (Cyanophyceae) and related species in the Nakdong River, South Korea

2016

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Background: The purpose of this study is to describe the morphological characteristics of the Aphanizomenon spp. and related species from the natural samples collected in the Nakdong River of South Korea. Aph. flos-aquae was similar to Aph. klebahnii, whereas these species differed from each other by the size and shape of fascicles, which was macroscopic in Aph. flos-aquae and microscopic in the Aph. klebahnii. One of their characteristics was that trichomes are easily disintegrating during microscopic examination. C. issatschenkoi could be clearly distinguished from other species by hair-shaped terminal cell. Its terminal cell was almost hyaline and markedly pointed. Young populations of the species without heterocytes run a risk of a misidentification. Aph. skujae was characterized by akinete. Morphological variability of akinetes from natural samples collected in the Nakdong River was rather smaller than those reported by previous study. Conclusions: C. issatschenkoi are described for the first time in the Nakdong River. In addition, Aph. klebahnii and Aph. skujae are new to South Korea.

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Cylindrospermopsin induces neurotoxicity in tilapia fish (Oreochromis niloticus) exposed to Aphanizomenon ovalisporum

Cited by 49 publications

References 52 publications

Influence of Cooking (Microwaving and Broiling) on Cylindrospermopsin Concentration in Muscle of Nile Tilapia (Oreochromis niloticus) and Characterization of Decomposition Products

Influence of Cooking (Microwaving and Broiling) on Cylindrospermopsin Concentration in Muscle of Nile Tilapia (Oreochromis niloticus) and Characterization of Decomposition Products

Potential Use of Chemoprotectants against the Toxic Effects of Cyanotoxins: A Review

Morphology and taxonomy of the Aphanizomenon spp. (Cyanophyceae) and related species in the Nakdong River, South Korea

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