Cyclotron production and radiochemical purification of 88,89Zr via α-particle induced reactions on natural strontium

Ivanov, P.; Jerome, S M; Bozhikov, G. A.; Maslov, O. D.; Starodub, G. Ya.; Дмитриев, С. Н.

doi:10.1016/j.apradiso.2014.04.018

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…The suitable nuclear characteristics of 89 Zr (supplementary Table-1) makes it a promising radionuclide in nuclear medicine for immuno-PET, bio-distribution studies, tracking and quantification of monoclonal antibodies (mAbs) 5 .Ever since its first utilization by Link et al in 1986, 89 Zrbased PET imaging has been investigated for a wide variety of cancer-related targets, including human epidermal growth factor receptor 2, prostate-specific membrane antigen, splice variant v6 of CD44, vascular endothelial growth factor, etc 6 . Another radioisotope of Zr; 88 Zr (T½ =83.4 d) is used as tracers for Zr radiochemistry studies and also for studying the radiochemistry and electrophoretic behavior of Zr(IV) at nanogram amounts 7 . 88,89 Zr may also be suitable therapeutic radionuclide in cellular level, since both of these radionuclides have high intensity auger electrons (supplementary Table1).…”

Section: Introductionmentioning

confidence: 99%

Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides

Kalpita¹,

Naskar²,

Choudhury³

et al. 2019

Preprint

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This paper exploits the affinity of bio-flavonoid hesperidin, isolated from orangepeel, towards the separation of clinically important 88Zr radionuclide from high energy proton bombarded yttrium target. The extraction of Zr with hesperidin was studied by solid-liquid extraction (SLX) technique over a wide pH range. The advantage of hesperidin is that it acts as separating agent as well as free-radical scavenging agent upon injection of the radionuclidehesperidin complex in-vivo. The stability of isolated hesperidin under strong radiation field was also studied. The selectivity of the bio-flavonoid towards 88Zr was maximum at pH=4 where in >78% Zr was extracted with <1% contamination from bulk yttrium target.

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Section: Introductionmentioning

confidence: 99%

Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides

Kalpita¹,

Naskar²,

Choudhury³

et al. 2019

Preprint

View full text Add to dashboard Cite

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Separation of 89Zr from irradiated yttrium targets by extraction chromatography

Kazakov

Алиев

Ostapenko

et al. 2018

J Radioanal Nucl Chem

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Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

Mansel

Franke

2021

J Radioanal Nucl Chem

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The chemical separation of zirconium from lanthanides by liquid–liquid extraction is challenging but critical for medical and technological applications. Using the example of 89Zr, we optimize the liquid–liquid-extraction process by means of the radiotracer technique. We produced 89Zr by proton irradiation of a metallic yttrium target at a cyclotron. The purification of the radionuclide was performed by a UTEVA resin. 89Zr was separated in no-carrier-added form in a sulfuric acid solution. 89Zr was successfully used in solvent extraction tests with calixarenes for the separation of zirconium from lanthanides. This reaction is suitable for the efficient extraction and purification of lanthanides.

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Cyclotron production and radiochemical purification of 88,89Zr via α-particle induced reactions on natural strontium

Cited by 8 publications

References 28 publications

Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides

Natural Flavonoids as Superior Reagents for Separation of Clinically Important Zr Radionuclides

Separation of 89Zr from irradiated yttrium targets by extraction chromatography

Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

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