Cyclosporin A inhibits the replication of diverse coronaviruses

Wilde, Adriaan H. de; Zevenhoven-Dobbe, Jessika C.; Meer, Yvonne van der; Thiel, Volker; Narayanan, Krishna; Makino, Shinji; Snijder, Eric J.; Hemert, Martijn J. van

doi:10.1099/vir.0.034983-0

Cited by 228 publications

(272 citation statements)

References 44 publications

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“…Cyclosporin A also has activity against coronaviruses. 17 Studies on the mode of action of cyclosporin, and the later developed immunosuppressants from actinomycetes, such as sirolimus (a rapamycin) and FK-506 (tacrolimus), have markedly expanded current knowledge of T-cell activation and proliferation. These agents act by interacting with an intracellular protein (an immunophilin), thus forming a novel complex that selectively disrupts the signal transduction events of lymphocyte activation.…”

Section: Anti-rejection Drugs (Agents That Suppress the Immune System)mentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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where he has contributed in a major way to the reputation of this department for many years. He also served as an Adjunct Professor at the University of Geneva. Among Julian's areas of study and accomplishment are fungal toxins including α-sarcin, chemical synthesis of triterpenes, mode of action of streptomycin and other aminoglycoside antibiotics, biochemical mechanisms of antibiotic resistance in clinical isolates of bacteria harboring resistance plasmids, their origins and evolution, secondary metabolism of microorganisms, structure and function of bacterial ribosomes, antibiotic resistance mutations in yeast ribosomes, cloning of resistance genes from an antibiotic-producing microbe, gene cloning for industrial purposes, engineering of herbicide resistance in useful crops, bleomycin-resistance gene in clinical isolates of Staphylococcus aureus and many other topics. He has been an excellent teacher, lecturing in both English and French around the world, and has organized international courses. Julian has also served on the NIH study sections, as Editor for several international journals, and was one of the founders of the journal Plasmid. We expect the impact of Julian's accomplishments to continue into the future.

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Section: Anti-rejection Drugs (Agents That Suppress the Immune System)mentioning

confidence: 99%

Production of valuable compounds by molds and yeasts

Demain

Martens

2016

J Antibiot

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“…reported that CsA inhibited the replication of CoVs (SARS–CoV, human 229E CoV, and mouse hepatitis virus (MHV)-A59) using green fluorescence protein (GFP)-expressing recombinant CoVs [25]. Namely, they used Vero-E6 cells and 293/ACE2 cells (these cells stably express the SARS–CoV receptor, ACE2) for infection of SARS–CoV.…”

Section: Csa Inhibits the Replication Of Diverse Covsmentioning

confidence: 99%

“…Therefore, CsA and non-immunosuppressive compounds that bind to Cyps such as NIM811, Debio-025, and SCY-635 inhibit HIV-1 and HCV replication [20,21,22,23,24]. Also, several laboratories have reported that CsA suppresses the replication of various kinds of CoVs [25,26,27]. …”

Section: Introductionmentioning

confidence: 99%

Suppression of Coronavirus Replication by Cyclophilin Inhibitors

Tanaka

Sato

Sasaki

2013

Viruses

147

159

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Coronaviruses infect a variety of mammalian and avian species and cause serious diseases in humans, cats, mice, and birds in the form of severe acute respiratory syndrome (SARS), feline infectious peritonitis (FIP), mouse hepatitis, and avian infectious bronchitis, respectively. No effective vaccine or treatment has been developed for SARS-coronavirus or FIP virus, both of which cause lethal diseases. It has been reported that a cyclophilin inhibitor, cyclosporin A (CsA), could inhibit the replication of coronaviruses. CsA is a well-known immunosuppressive drug that binds to cellular cyclophilins to inhibit calcineurin, a calcium-calmodulin-activated serine/threonine-specific phosphatase. The inhibition of calcineurin blocks the translocation of nuclear factor of activated T cells from the cytosol into the nucleus, thus preventing the transcription of genes encoding cytokines such as interleukin-2. Cyclophilins are peptidyl-prolyl isomerases with physiological functions that have been described for many years to include chaperone and foldase activities. Also, many viruses require cyclophilins for replication; these include human immunodeficiency virus, vesicular stomatitis virus, and hepatitis C virus. However, the molecular mechanisms leading to the suppression of viral replication differ for different viruses. This review describes the suppressive effects of CsA on coronavirus replication.

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“…CsA reportedly inhibits the replication of various viruses such as human immunodeficiency virus type-1, hepatitis C virus, coronaviruses, vaccinia virus, vesicular stomatitis virus, herpes simplex virus, and BK polyomavirus (9)(10)(11)(12)(13)(14)(21)(22)(23)(24)(25)(26). CsA has antiviral effects on a wide range of viruses; therefore, we hypothesized that CsA would inhibit the multiplication of influenza virus.…”

Section: Discussionmentioning

confidence: 99%