Cyclospora Infection in Adults Infected with HIV: Clinical Manifestations, Treatment, and Prophylaxis

Pape, Jean William; Verdier, Rose-Irene; Boncy, Madeleine; Boncy, Jacques; Johnson, Warren D.

doi:10.7326/0003-4819-121-9-199411010-00004

Cited by 222 publications

(95 citation statements)

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“…In the early 1980s, Cyclospora was recognized as a pathogen in patients with AIDS. It is now known that Cyclospora is endemic in many parts of the world, with a higher prevalence in tropical and subtropical countries (Ashford, 1979;Hart et al, 1990;Pape et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

“…If not treated, the illness may last for a few days to a month or longer. The symptoms associated with infection with the organism have been reported to resemble those of cryptosporidial infection, including watery diarrhoea, nausea, weight loss and abdominal pain (Hart et al, 1990;Pape et al, 1994;Albert et al, 1994;Shields & Olson, 2003). Because Cyclospora resembles the Cryptosporidium oocyst in modified Kinyoun's acid-fast stain, it is strongly recommended that all laboratories screening for the latter parasite make precise measurements of oocysts.…”

Section: Introductionmentioning

confidence: 99%

“…It is quite possible that many cases of diarrhoea reported to be due to Cryptosporidium might actually be due to Cyclospora. Because Cyclospora organisms have now been isolated from patients with AIDS and chronic diarrhoea, this infection should be carefully distinguished from cryptosporidiosis (Long et al, 1990;Ortega et al, 1993;Pape et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Cyclosporiasis associated with diarrhoea in an immunocompetent patient in Turkey

Türk

Türker

et al. 2004

Journal of Medical Microbiology

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cyclosporiasis associated with diarrhoea in an immunocompetent patient in Turkey

Türk

Türker

et al. 2004

Journal of Medical Microbiology

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“…Apart from the intrinsic need to contribute to the pool of knowledge, such a diagnosis is necessary as there is specific chemotherapy available against Cyclospora cayetanensis which can alleviate the symptoms promptly and effect a radical medical cure as was demonstrated clearly in all our cases. Cyclospora organisms have also been isolated in chronic diarrhoea and this infection should be carefully distinguished from cryptosporidiosis [20,21,22].…”

Section: Discussionmentioning

confidence: 99%

Cyclospora cayetanensis: First report of imported and autochthonous infections in Kuwait

Iqbal

Hira

Al-Ali

et al. 2011

J Infect Dev Ctries

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Introduction: The intestinal coccidian parasites Cryptosporidium spp. and Cyclospora cayetanensis have emerged as significant human pathogens worldwide. The reports of Cyclospora cayetanensis infection in the Middle East are sporadic and no case has been reported from Kuwait. Methodology: Stool specimens were collected from six individuals presenting with watery diarrhoea of varying degree and severity at the District General hospitals, Kuwait. Four patients were male, two were female and their ages ranged from 5 to 64 years. Three cases were seen among the migrant population from the Indian subcontinent who had recently returned to Kuwait and two cases were seen in the local population with no history of travel abroad. The stool smears were stained with modified acid-fast stain and examined under ultraviolet (UV) fluorescence illumination. . Results: Cyclospora cayetanensis oocysts with variable staining characteristics were detected by microscopy. Two of the cases were also associated with other enteric pathogens. Clinical suspicion of Cyclospora infection was not recorded for any of the cases. All patients showed remarkable symptomatic and parasitologic improvements upon treatment with trimethoprim/sulfamethoxazole. Conclusion: Cyclospora spp. are important aetiological agents of diarrhoea in the Middle East. An awareness of the parasitic infection and use of appropriate diagnostic modalities are essential to elucidate the clinical and epidemiological significance of the parasitosis in this geographic area.

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“…Cuando los pacientes no consultan tempranamente, la diarrea persiste por varias semanas; se puede dar la El tratamiento más utilizado es el trimetoprimsulfametoxazole que se ha empleado también para profilaxis. Esta asociación de medicamentos se considera el tratamiento de elección para Cyclospora y, además, se utiliza en los pacientes con sida en el tratamiento de la isosporosis y toxoplasmosis (33,34), pero no es efectivo para Cryptosporidium (35,36). La nitazoxanida, un medicamento reciente ya comercializado en México, útil contra protozoos y helmintos intestinales, fue efectiva en el único paciente al cual se le administró para Cyclospora; también se considera promisoria en el tratamiento de criptosporidiosis (37,38).…”

Section: Identificación De Cyclosporaunclassified

Infección por Cyclospora sp. en tres pacientes inmunocompetentes

et al. 2000

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ResumenSe presentan tres casos de pacientes inmunocompetentes con síndrome diarreico que consultaron al Instituto Colombiano de Medicina Tropical en Medellin. El único agente patógeno aislado de sus muestras fecales fue Cyclospora sp. Una paciente fue tratada con un medicamento antiparasitario experimental, la nitazoxanida, y los otros dos pacientes con trimetroprim-sulfametoxazole, todos con buenos resultados. Se presenta una revisión de algunos aspectos de la enfermedad y se recomienda que, en casos de diarrea prolongada, se disponga de un protocolo completo para estudio de parásitos en materia fecal, además de capacitar muy bien al personal de salud que lee los coprológicos para establecer un diagnóstico diferencial entre el grupo de las coccidias.Palabras clave: coccidia, Cyclospora, diarrea crónica Cyclospora sp. infection i n three immunocompetent patients We describe three patients seen at the Instituto Colombiano de Medicina Tropical in Medellin, in whose case the only parasitic agent incriminated as the cause of prolonged diarrhea was the protozoan Cyclospora sp. One patient was treated with a new antiparasitic drug, nitazoxanide, and the other two with trimethoprim-sulfamethoxazole, al1 with good results. A revision of some aspects of the illness is presented. It is recommended that in cases of prolonged diarrhea, a complete protocol for the study of parasites in faeces be established and that the microscopists be trained to identify the coccidian pathogens.

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Cyclospora Infection in Adults Infected with HIV: Clinical Manifestations, Treatment, and Prophylaxis

Abstract: Cyclospora infection is common in Haitian patients with HIV infection, responds to trimethoprim-sulfamethoxazole therapy, and has a high recurrence rate that can be largely prevented with long-term trimethoprim-sulfamethoxazole prophylaxis.

Cited by 222 publications

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Cyclosporiasis associated with diarrhoea in an immunocompetent patient in Turkey

Cyclosporiasis associated with diarrhoea in an immunocompetent patient in Turkey

Cyclospora cayetanensis: First report of imported and autochthonous infections in Kuwait

Infección por Cyclospora sp. en tres pacientes inmunocompetentes

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