Cyclooxygenase Inhibition Potentiates the Pulmonary Vascular Responses to Ethanol in Dogs

Abstract

The effects of ethanol on pulmonary hemodynamics and the role of arachidonic acid metabolites in mediating these responses were studied in the isolated, blood-perfused canine lung lobe. Ethanol added directly to the venous reservoir at a concentration of 0.01 or 0.1 % did not alter the pulmonary vascular resistance, however, 1.0% ethanol increased (p < 0.05) the pulmonary resistance. Indometacin, a cyclooxygenase inhibitor, significantly increased baseline pulmonary vascular resistance and markedly potentiated the pulmonary vascular responses to the three concentrations of ethanol. Addition of nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, followed by indometacin, did not diminish the indometacin-induced increases in basal tone or enhancement of the responses to ethanol indicating that leukotrienes are not involved in mediating the responses to ethanol. These results suggest that in isolated, blood-perfused dog lung lobe, a high concentration of ethanol increases the pulmonary vascular resistance and that cyclooxygenase inhibition markedly potentiated the responses to ethanol by reducing the production of vasodilator prostaglandin, most probably prostacyclin.

Study of the structure and refractive parameters of diethylamine and triethylamine

“…At optical high frequencies the permittivity of a material cannot be measured by the use of electrical methods. However, it is known from Maxwell's theory for electromagnetic waves that for non-magnetic materials the permittivity is related to the refractive index as follows [3][4][5][6]:…”

“…In the VIS range the spectrum of the refractive index, n l ; has been described by the use of the well-known Cauchy equation [11], truncated to a three-parameter form: A, B and C constants are determined by using Cauchy's equation (4) for four wavelengths at 20 C. We obtain the following relation for diethylamine and triethylamine, respectively, n ¼ 1:3690 þ 3153:0173=l 2 þ À2:618 Â 10 8 =l 4 ; …”

“…[3][4][5][6]. Additionally, Hawranek and co-workers have studied liquid triethylamine by using a Bellingham+Stanley model 60/ED high-accuracy Abbe refractometer [7,8].…”