Cyclooxygenase Inhibition for Postoperative Analgesia

McCrory, Connail; Lindahl, Sten G. E.

doi:10.1097/00000539-200207000-00030

Cited by 65 publications

(31 citation statements)

References 103 publications

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“…Preemptive analgesic effect was obvious with NSAIDs due to their mode of action, competing with arachidonic acid for binding to cyclooxygenase and decreasing the formation of prostaglandins (23). Treatment with NSAIDs should be started as early as possible and should be initiated before the input of nociceptive stimuli.…”

Section: Discussionmentioning

confidence: 99%

The comparison of preemptive analgesic effects of curcumin and diclofenac

Nurullahoglu¹,

Okudan²,

Belviranlı³

et al. 2014

BLL

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Abstract:Objective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and infl ammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw fl inching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg -1 , p.o.) and diclofenac (10 mg kg -1 , i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was signifi cant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of fl inches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcumin had preemptive analgesic effects on acute thermal, and infl ammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.

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Section: Discussionmentioning

confidence: 99%

The comparison of preemptive analgesic effects of curcumin and diclofenac

Nurullahoglu¹,

Okudan²,

Belviranlı³

et al. 2014

BLL

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“…Los anestesiólogos tienen un rol central en el manejo del dolor postoperatorio agudo, y su manejo efectivo ha demostrado mejorar los resultados clínicos en los pacientes sometidos a procedimientos quirúrgicos [3,9]. Cada paciente tiene una única percepción del dolor que requiere un plan individualizado para el manejo del mismo [10].…”

Section: Segúnunclassified

“…La meta a alcanzar en el manejo del dolor postoperatorio es obtener un nivel óptimo de analgesia, facilitando que el paciente regrese rápidamente a sus funciones fisiológicas normales, con los mínimos efectos adversos [9,12].…”

Section: Segúnunclassified

“…El uso conjunto de AINEs incrementa el riesgo de presentar: sangrado en el sitio de la operación, sangrado gastrointestinal, disfunción renal, reacciones alérgicas, broncoespasmo, e hipertensión [9,12,19,23,24,36,37]. Además, durante el período postoperatorio hay factores tales como ayuno y alta prevalencia de hipovolemia, los cuales pueden potenciar los efectos adversos gástricos y renales.…”

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Caracterización del uso de analgésicos y antiinflamatorios en el postoperatorio inmediato de pacientes adultos intervenidos quirúrgicamente en un Hospital privado de Costa Rica en el período Noviembre 2008 - Abril 2009

et al. 2010

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“…Prostanoids generated by COX-2 play an important role in inflammatory and painful reactions to tissue damage (Ferreira, 2002;McCrory and Lindahl, 2002). Apart from their positive effects, NSAIDs may also have numerous negative effects, impairment of kidney function being among the most severe.…”

mentioning

confidence: 99%

Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs

Raušer¹,

Stehlík²,

Proks³

et al. 2010

Vet. Med.

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Carprofen or meloxicam are nonsteroidal anti-inflammatory drugs (NSAIDs), which may elicit a variety of renal disturbances. Prior to this study, the effects of carprofen or meloxicam on renal function in pigs were unknown. A total of 21 clinically healthy Goettingen miniature pigs (36.9 ± 7.22 kg) were divided into three groups based on what they were administered -carprofen, meloxicam or saline. First, blood was collected from the jugular vein and urine by ultrasound-guided cystocentesis. Serum urea (U) and creatinine (CR), fractional clearance of sodium (FCNa), urine gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities, urine protein/creatinine ratio (UP/UC), urine gamma-glutamyltransferase/creatinine ratio (GGT/CR) and urine alkaline phosphatase/creatinine ratio (ALP/CR) and urine analysis -urine specific gravity (USG) and sediment microscopy were assessed before and seven days after daily intramuscular administration (IM) of saline (1.5 ml per animal), carprofen (2 mg/kg) or meloxicam (0.1 mg/kg). All animals had identical housing, feeding and unlimited water intake and had not undergone surgery or been administered any medication for three months prior to this. All pigs served as control groups for an experimental study of fracture healing using transplantation of mesenchymal stem cells and scaffolds. The data were analyzed using a one way ANOVA and a Mann-Whitney test (P < 0.05). In pigs receiving carprofen, serum urea and creatinine were significantly decreased, compared to the control (P < 0.01) or meloxicam (P < 0.05) groups. In animals receiving meloxicam FCNa was significantly increased (P < 0.05) and urine specific gravity significantly decrease (P < 0.05) compared to the pretreatment values. Two carprofentreated pigs had a slight increase in renal tubular epithelial cells upon urine sediment examination. Intramuscular administration of carprofen or meloxicam in healthy miniature pigs for seven days causes no clinically important changes in selected renal parameters (without azotemia). However these changes indicate mild damage of renal tubules. Despite these findings, meloxicam or carprofen are recommended for analgesia in healthy pigs.

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Cyclooxygenase Inhibition for Postoperative Analgesia

Cited by 65 publications

References 103 publications

The comparison of preemptive analgesic effects of curcumin and diclofenac

The comparison of preemptive analgesic effects of curcumin and diclofenac

Caracterización del uso de analgésicos y antiinflamatorios en el postoperatorio inmediato de pacientes adultos intervenidos quirúrgicamente en un Hospital privado de Costa Rica en el período Noviembre 2008 - Abril 2009

Effect of seven-day administration of carprofen or meloxicam on renal function in clinically healthy miniature pigs

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