Cycloheximide produces amnesia for extinction and reconsolidation in an appetitive odor discrimination task in rats

Gotthard, Gretchen Hanson; Knoppel, Alexandra B.

doi:10.1016/j.nlm.2009.09.002

Cited by 9 publications

(10 citation statements)

References 46 publications

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“…: 55–63]. There are also reports of impairment of extinction in appetitive tasks [50,64], and it will be important to assess the nature of neurobiological bases of arousal in these conditions.…”

Section: Discussionmentioning

confidence: 99%

Cycloheximide impairs and enhances memory depending on dose and footshock intensity

Gold

Wrenn

2012

Behavioural Brain Research

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This experiment examined the effects on memory of interactions of cycloheximide dose and training foot shock intensity. Mice received injections of cycloheximide (120 mg/kg, s.c.) or saline 30 min prior to inhibitory avoidance training with shock intensities of 100, 150, 250 or 300 µA (1 sec duration). Memory was tested 48 hr later. The saline control mice showed increasing memory latencies as a function of shock intensity. The ability of cycloheximide to impair memory increased as the training shock intensity increased. In a second experiment, mice were trained with a 200 µA (1 sec duration) shock and received injections of saline or cycloheximide at one of several doses (30, 60 or 120 mg/kg). Under these training conditions, cycloheximide enhanced memory in an inverted-U dose-response manner. These findings are consistent with prior findings suggesting that protein synthesis inhibitors act on memory by altering modulators of memory formation as a secondary consequence of the inhibition of protein synthesis rather than by interfering with training-initiated synthesis of proteins required for memory formation.

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Section: Discussionmentioning

confidence: 99%

Cycloheximide impairs and enhances memory depending on dose and footshock intensity

Gold

Wrenn

2012

Behavioural Brain Research

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“…If the hypothesis that protein synthesis is essential for memory of extinction learning is correct [12,[14][15][16], then protein synthesis inhibition should impede this process, regardless of the animal . Cycloheximide did not interfere with acquisition, as avoidance performance during training did not differ significantly from that of the vehicle group.…”

Section: Administration Of Cxm Before the Extinction Sessionsmentioning

confidence: 99%

“…In many studies, PSIs have been found to interfere with extinction [11][12][13][14][15][16][17][18][19][20][21], although it has also been reported that PSIs facilitate [18,22] or have no effect [23,24] on this type of learning.…”

Section: Introductionmentioning

confidence: 99%

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

González-Salinas

Medina

Marín-Vignando

et al. 2015

Behavioural Brain Research

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“…The vast majority of reconsolidation studies employed aversive paradigms, including active avoidance learning (Flood, Jarvik, Bennett, Orme, & Rosenweig, 1977), conditioned fear (Dêbiec et al, 2002; Nader et al, 2000), spatial learning in the Morris water maze (Lattal & Abel, 2004), and conditioned taste aversion (Flint & Marino, 2007). Reconsolidation deficits were also shown in studies using appetitive paradigms, including odor discriminations (Gotthard & Knöppel, 2010) and operant lever pressing (Exton-McGuinness, Patton, Sacco, & Lee, 2014; Wang, Ostlund, Nader, & Balleine, 2005). The present study expands the literature on appetitive reconsolidation disruption by employing a reward-based operant digging task followed by administration of the protein synthesis inhibitor CHX.…”

mentioning

confidence: 87%

Reconsolidation of appetitive odor discrimination requires protein synthesis only when reactivation includes prediction error.

Gotthard¹,

Kenney²,

Zucker³

2018

Behavioral Neuroscience

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Reconsolidation theory has supported the notion that active memory is vulnerable to the effects of an amnesic agent. An extension of reconsolidation theory posits that active memory, while necessary for creating vulnerability in memory, is not sufficient. Prediction error (i.e., when expectation is inconsistent with reality) may be a key factor in the destabilization of memory. The present study examined the role of prediction error in appetitive memory reconsolidation. Rats learned to dig in cups of scented sand to retrieve buried sweet cereal rewards. Forty-eight hours following acquisition, a single reactivation trial was given during which a prediction error or no prediction error was included. The prediction error consisted of a single extinction trial, while the no prediction error condition consisted of an additional reinforced trial. Cycloheximide (CHX; 1 mg/kg) or vehicle (VEH: distilled water; 1 mg/kg) was administered intraperitoneally immediately following reactivation. One week following reactivation, rats received 2 nonreinforced test trials. Results showed longer latencies to dig for rats that received CHX following a prediction error (CHX/PE) compared to rats that received VEH (VEH/PE) or did not receive a prediction error (CHX/NoPE or VEH/NoPE). These results add to a growing literature demonstrating that protein synthesis is necessary in appetitive memory reconsolidation only when reactivation includes a prediction error. (PsycINFO Database Record

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Cycloheximide produces amnesia for extinction and reconsolidation in an appetitive odor discrimination task in rats

Cited by 9 publications

References 46 publications

Cycloheximide impairs and enhances memory depending on dose and footshock intensity

Cycloheximide impairs and enhances memory depending on dose and footshock intensity

Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

Reconsolidation of appetitive odor discrimination requires protein synthesis only when reactivation includes prediction error.

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