Protein synthesis is not required for acquisition, consolidation, and extinction of high foot-shock active avoidance training

González-Salinas, Sofía; Medina, Andrea C.; Marín-Vignando, Vera; Ruiz-López, Clyo X.; Quírarte, Gina L.; Prado-Alcalá, Roberto A.

doi:10.1016/j.bbr.2015.03.031

Cited by 10 publications

(6 citation statements)

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“…Escape latency in an active avoidance test was used to measure coping style, using the method of a previous report with slight modifications (González-Salinas et al, 2015 ). The test was performed in a two-compartment shuttle box with steel grids on the floor and a guillotine door separating the two compartments.…”

Section: Methodsmentioning

confidence: 99%

Age-Related Decrease in Stress Responsiveness and Proactive Coping in Male Mice

Song

Kim

et al. 2018

Front. Aging Neurosci.

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Coping is a strategic approach to dealing with stressful situations. Those who use proactive coping strategies tend to accept changes and act before changes are expected. In contrast, those who use reactive coping are less flexible and more likely to act in response to changes. However, little research has assessed how coping style changes with age. This study investigated age-related changes in coping strategies and stress responsiveness and the influence of age on the processing of conditioned fear memory in 2-, 12- and 23-month-old male mice. Coping strategy was measured by comparing the escape latency in an active avoidance test and by comparing responses to a shock prod. The results showed that proactivity in coping response gradually decreased with age. Stress responsiveness, measured by stress-induced concentration of corticosterone, was also highest in 2-month-old mice and decreased with age. Consolidation of fear memory was highest in 12-month-old mice and was negatively correlated with the degree of stress responsiveness and proactivity in coping. Fear extinction did not differ among age groups and was not correlated with stress responsiveness or the proactivity of coping. However, the maintenance of extinct fear memory, which was best in 2-month-old mice and worst in 12-month-old mice, was negatively correlated with stress responsiveness but not with coping style. Age-dependent changes in the expression of glucocorticoid receptor (GR) and its regulatory co-chaperones, which are accepted mechanisms for stress hormone stimulation, were measured in the hippocampus. The expression of GR was increased at 12 months compared to other age groups. There were no differences in Hsp70 and BAG1 expression by age. These results can be summarized as follows: (1) stress responsiveness and proactivity in coping decreased with age class; (2) consolidation of fear memory was negatively correlated with both stress responsiveness and proactivity; however, maintenance of extinct fear memory was negatively correlated with stress responsiveness only; and (3) consolidation and maintenance of extinct fear memory appeared to be more influenced by factors other than stress reactivity and proactivity in coping, such as the amount of hippocampal glucocorticoid expression.

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Section: Methodsmentioning

confidence: 99%

Age-Related Decrease in Stress Responsiveness and Proactive Coping in Male Mice

Song

Kim

et al. 2018

Front. Aging Neurosci.

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“…In the study of Diaz-Trujillo et al 2009, higher shock intensities overrode the effects of protein synthesis inhibition (cycloheximide) on memory. Similarly, other studies have demonstrated that the amnesic effects of cycloheximide decrease with increased shock intensity (Flood et al, 1972;Gonzalez-Salinas et al, 2015). Together, these findings suggest that cycloheximide memory impairment is evident only at moderate shock levels but not at high shock levels.…”

Section: Discussionsupporting

confidence: 66%

“…De maneira similar, outros estudos demonstram que a cicloheximida tem seus efeitos amnésicos diminuídos com o aumento da intensidade do choque (Flood et al, 1972;Gonzalez-Salinas et al, 2015). Juntos, esses achados sugerem que o prejuízo na memória causado pela cicloheximida é evidente somente quando a intensidade do choque é moderada, e não intensa.…”

Section: Os Resultados Obtidos No Nosso Estudo São Opostos Aos Obtidounclassified

“…Neste sentido, alguns autores demonstraram que ratos apresentaram prejuízo na consolidação da memoria induzida por inibidores de síntese proteica somente quando submetidos ao protocolo de condicionamento com intensidade moderada (e não elevada) de choque nas patas (Diaz-Trujillo et al, 2009;Gonzalez-Salinas et al, 2015), enquanto que Gold e Wrenn (2012) descreveram que camundongos apresentaram amnésia induzida por inibidores de síntese proteica somente quando a intensidade do choque nas patas foi elevada.…”

Section: Introdução Memóriaunclassified

“…Paradigms similar to this have been used to investigate the interaction between protein synthesis inhibitors and the intensity of the US on memory consolidation. Some authors found that consolidation impairment induced by protein synthesis inhibitors only occurs with moderate, not high, foot-shocks (Diaz-Trujillo et al, 2009;Gonzalez-Salinas et al, 2015), while Gold and Wrenn (2012) reported an amnestic effect only in the case of high foot-shock intensity.…”

Section: Introductionmentioning

confidence: 99%

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