Cycloheximide induced amnesia and recovery as a function of training parameters

Quinton, Elton E.

doi:10.1016/0091-3057(74)90049-5

Cited by 18 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mice administered CYC either before or immediately after training performed poorly on the test trial 72 hr after training. These results are consistent with earlier reports of CYC-induced amnesia of passive avoidance tasks (Flood, Bennett, Rosenzweig, & Orme, 1972;Geller, Robustelli, Barondes, Cohen, & Jarvik, 1969;Quinton, 1974). However, the administration of 5 mg/kg d-amp immediately after training seemed to protect against the amnesic effect of CYC.…”

Section: Discussionsupporting

confidence: 93%

“…When DDC is administered either shortly before or after training, the degree of resultant memory impairment appears to be comparable with that of CYC given under similar conditions. However, DDC also impairs memory when it is adminis-tered up to 3 hr after training, whereas CYC is not effective when administered 1 hr after training (Quinton, 1974). Furthermore, pretest administration of d-amp induces a partial recovery of memory in DDC-pretreated mice but has no effect on CYC-pretreated mice.…”

Section: Discussionmentioning

confidence: 94%

“…We suggest that the difference in the effectiveness of pretest d-amp in the two studies is due to the difference in relative permanence of CYC-induced amnesia observed in the two studies. Pretest administration of d-amp, and other adrenergic stimulants, may facilitate apparent recovery in situations in which "memory," or more probably performance (Quinton, 1974), is temporarily impaired but spontaneously recovers at some later time. However, in situations in which spontaneous recovery of memory does not normally occur, as in the present study, then pretest administration of d-amp does not improve test performance.…”

Section: Discussionmentioning

confidence: 99%

“…In these studies transitory amnesia was observed 24 hr after training, and recovery 48 hr 1390 after training. It seems plausible to suggest that the combination of immediate posttraining and pretest administration of adrenergic stimulants does not prevent the development of some transitory amnesia or facilitate retrieval of memory in amnesic animals, but rather it counteracts the impairment of learned performance by CYC or AXM 24 hr after administration (Quinton, 1974) and permits the overtrained animals to perform normally, as they do 48 hr after CYC.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.

Quinton¹,

Bloom²

1977

Journal of Comparative and Physiological Psychology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.

Quinton¹,

Bloom²

1977

Journal of Comparative and Physiological Psychology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The present study was initiated to test this prediction, using the antibiotic cycloheximide (CYC). When administered prior to training, CYC is a very effective amnesic agent (Quinton, 1974;Quinton & Bloom, 1977). Furthermore, the degree of amnesia after pretraining administration of CYC is dose dependent and strongly correlated with the degree of inhibition of protein synthesis at the time of training (Quinton & Kramarcy, 1977).…”

mentioning

confidence: 99%

Subamnesic cycloheximide treatment delays consolidation in mice.

Quinton¹

1978

Journal of Comparative and Physiological Psychology

Self Cite

View full text Add to dashboard Cite

In the first experiment, groups of C57 BL/6J mice were given passive avoidance training and then administered different doses of cycloheximide (CYC) immediately, 30 min, or 1 hr after training. Only the highest dose (150 mg/kg) administered immediately or 30 min after training impaired memory when the mice were tested 72 hr after training. In the second experiment, mice were given a nonamnesic administration of CYC (30 mg/kg) or saline immediately after training and another injection of CYC (15 mg/kg, 30 mg/kg, or 75 mg/kg) or saline 1 hr after training. Single injections of CYC and the combination of 30 mg/kg +15 mg/kg did not impair memory, but the combinations of 30 mg/kg + 30 mg/kg and 30 mg/kg + 75 mg/kg did impair memory. The third experiment demonstrated that brief carbon dioxide anesthetization initiated immediately after training impairs memory. In the fourth experiment, mice were given either saline or 30 mg/kg CYC immediately after training and then subjected to either air or CO2 anesthetization 30 min after training. Only the group given 30 mg/kg CYC + CO2 was amnesic when tested 72 hr after training. The results of these experiments indicate that the administration of a nonamnesic dose of CYC immediately after training renders the memory susceptible to disruption by additional doses of CYC or other amnesic treatments for a longer period of time than normal. It is suggested that CYC delays consolidation and prolongs the labile period of memory formation.Flood and his associates have reported subsequent injections of low doses of ANI data which indicate that prolonging the pe-every 2 hr. They generally found that the riod of inhibition of cerebral protein syn-degree of memory impairment was a functhesis (CPS) after a learning experience by tion of the duration of continuous inhibition repeated posttraining injections of an anti-(> 80%) of CPS. Neither a single pretrainbiotic increases the severity of the memory ing injection of the low dose of ANI nor impairment. These investigators conclude posttraining injections without the prethat their data indicate that CPS occurring training injection produced a memory dechours after behavioral training is directly rement (Flood et al., 1973(Flood et al., ,1975a(Flood et al., , 1975b. involved in memory formation for the These data do seem to support the contraining experience (Flood, Bennett, Orme, tention that the prolonged inhibition of CPS & Rosenzweig, 1975a, 1975b Flood, Bennett, after training impairs memory by sup-Rosenzweig, & Orme, 1973).pressing memory-related protein synthesis The paradigm employed by the previous for long periods of time after training, researchers typically involved the adminis-However, they do not necessarily indicate tration of a subamnesic dose of anisomycin that specific, memory-related protein syn-(ANI) shortly before training, followed by thesis normally occurs several hours after training. If long-term memory formation This research was supported by Grant NS-12129-02 involves some metabolic process, which from the Nation...

show abstract

Effect of activation and blockade of the GABAergic system on disturbance of memory trace reproduction

Дубровина¹,

Il'yuchenok²

1988

Neurosci Behav Physiol

View full text Add to dashboard Cite

Cycloheximide induced amnesia and recovery as a function of training parameters

Cited by 18 publications

References 24 publications

Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.

Effects of d-amphetamine and strychnine on cycloheximide- and diethyldithiocarbamate-induced amnesia in mice.

Subamnesic cycloheximide treatment delays consolidation in mice.

Effect of activation and blockade of the GABAergic system on disturbance of memory trace reproduction

Contact Info

Product

Resources

About