Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus <i>Beauveria felina</i> EN-135

Du, Feng‐Yu; Zhang, Peng; Li, Xiaoming; Li, Chun‐Shun; Cui, Chuan‐Ming; Wang, Bin‐Gui

doi:10.1021/np4011037

Cited by 51 publications

(47 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports revealed that IDTs possessed various bioactivities including antibiotic [4,5] and anti-insectan potency [6,7] as well as tremorgenic mammalian mycotoxicity [8,9]. During our investigation on marine-derived fungi, a series of structurally interesting secondary metabolites such as cyclohexadepsipeptides [10], diketopiperazine alkaloids [11], and diphenylketones [12] were discovered. Recently, we focused our attention on Penicillium sp.…”

Section: Introductionmentioning

confidence: 97%

Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

Meng

et al. 2017

Marine Drugs

Self Cite

View full text Add to dashboard Cite

Three new indolediterpenoids, namely, 22-hydroxylshearinine F (1), 6-hydroxylpaspalinine (2), and 7-O-acetylemindole SB (3), along with eight related known analogs (4–11), were isolated from the sea-anemone-derived fungus Penicillium sp. AS-79. The structures and relative configurations of these compounds were determined by a detailed interpretation of the spectroscopic data, and their absolute configurations were determined by ECD calculations (1 and 2) and single-crystal X-ray diffraction (3). Some of these compounds exhibited prominent activity against aquatic and human pathogenic microbes.

show abstract

Section: Introductionmentioning

confidence: 97%

Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

Meng

et al. 2017

Marine Drugs

Self Cite

View full text Add to dashboard Cite

show abstract

“…Chloramphenicol and amphotericin B were used as positive controls against the bacteria and fungi, respectively. Evaluation of brine shrimp lethality against A. salina was performed as previously reported [17]. …”

Section: Methodsmentioning

confidence: 99%

20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment

Liu

et al. 2018

Marine Drugs

Self Cite

View full text Add to dashboard Cite

Four new uncommon 20-nor-isopimarane diterpenoid epimers, aspewentins I−L (1–4), together with a new methylated derivative of 3, aspewentin M (5), were isolated from the deep sea sediment-derived fungus Aspergillus wentii SD-310. The very similar structures of these epimers made the separation and purification procedures difficult. The structures of compounds 1–5 were illustrated based on spectroscopic analysis, and the absolute configurations of compounds 1–5 were unambiguously determined by the combination of NOESY, time-dependent density functional (TDDFT)-ECD calculations, and X-ray crystallographic analysis. These metabolites represented the rare examples of 20-nor-isopimarane analogues possessing a cyclohexa-2,5-dien-1-one moiety. These compounds were tested for antimicrobial activities against human and aquatic pathogenic bacteria, as well as plant-pathogenic fungi. While compounds 1 and 2 exhibited inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio harveyi, and V. parahaemolyticus, compound 5 showed potent activity against the plant pathogen Fusarium graminearum.

show abstract

“…and B. felina fungi. Du et al [169] reported the isolation of three new isaridins, namely, isaridin G, desmethylisaridin G, and desmethylisaridin C1. The structures of these compounds were elucidated by the X-ray crystallographic method.…”

Section: Classification Of Marine Resourcesmentioning

confidence: 99%

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

2017

View full text Add to dashboard Cite

Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market.

show abstract

Cyclohexadepsipeptides of the Isaridin Class from the Marine-Derived Fungus Beauveria felina EN-135

Cited by 51 publications

References 19 publications

Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79

20-Nor-Isopimarane Epimers Produced by Aspergillus wentii SD-310, a Fungal Strain Obtained from Deep Sea Sediment

Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications

Contact Info

Product

Resources

About