Cyclodextrins as food ingredients

Szente, Lajos; Szejtli, J.

doi:10.1016/j.tifs.2003.09.019

Cited by 616 publications

(427 citation statements)

References 4 publications

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“…A linear relationship between the amount of dissolved yarrow oil and the concentration of HPβCD in this study with slope less than one was classified as a typical A L -type (type A reveals an inclusion complex formation where the amount of entrapped essential oil increases as the HPβCD concentration increases, subscript L indicates a 1:1 molecular ratio formation of soluble complexes) (Higuchi & Connors, 1965). A 1:1 inclusion complex formation can be observed when the major entrapped compounds are monoterpenoids/sesquiterpenoids or phenylpropane derivatives with an average molecular weight of 120-160 g/mol (Szente & Szejtli, 2004). The molar ratio of host-to-guest molecules is usually 1:1 for inclusion complexes formed in solution, except for complexes with long-chain or bifunctional guest molecules (e.g.…”

Section: Phase Solubility Studymentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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Essential oil from yarrow (Achillea millefolium L. s. l.) has a broad spectrum of pharmacological activities. However, active chemical components of yarrow oil are sensitive to environmental factors such as, light, oxygen and temperature. Encapsulation of essential oil offers solutions for the limitation. Yarrow oil was encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) through freezedrying technique with encapsulation efficiency of 45%. Inclusion complex formation was examined by scanning electron microscope, Fourier transformed infrared spectroscopy and UV-vis analysis and phase solubility study. Yarrow oil gave strong antioxidant activity of 72% DPPH scavenging at 50 μg/mL. HPβCD could protect active compounds of essential oil and retained antioxidant activity after sunlight exposure. Yarrow oil also exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with the minimum inhibitory concentration (MIC) values of 250 μg/mL and 500 μg/mL, respectively. The antibacterial efficacy was much improved after encapsulation against both S. aureus and E. coli with the MIC value of 62.5 μg/mL.Encapsulación de aceite esencial de milenrama en hidroxipropil-beta-ciclodextrina. Caracterización fisicoquímica y evaluación de bioeficiencia. RESUMENEl aceite esencial de la milenrama (Achillea millefolium L. s. l.) presenta un amplio espectro de actividades farmacológicas. Sin embargo, los componentes químicos activos del aceite son sensibles a factores ambientales tales como, luz, oxígeno y temperatura. La encapsulación del aceite esencial ofrece soluciones para esta limitación. El aceite se encapsuló en hidroxipropil-β-ciclodextrina (HPβCD) mediante la técnica de liofilización con un rendimiento del 45%. La formación del complejo de inclusión se analizó mediante técnicas de SEM, FT-IR y UV-vis y se realizó un estudio de solubilidad. El aceite presentó una fuerte actividad antioxidante de 72% de DPPH. HPβCD protege los compuestos activos de aceite esencial y retoene la actividad antioxidante después de la exposición a luz solar. El aceite también exhibió actividad antibacteriana contra Staphylococcus aureus y Escherichia coli con valores mínimos de concentración inhibitoria (MIC) de 250 μg/mL y 500 μg/mL, respectivamente. La eficacia antibacteriana mejoró mucho después de la encapsulación contra S. aureus y E. coli con un valor de CIM de 62,5 μg /ml. ARTICLE HISTORY

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Section: Phase Solubility Studymentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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“…β-CD is also easy to recover industrially through the crystallization process [103], and it has the lowest solubility and an intermediate size ( Table 1). In addition, β-CD production is the most economically viable, with an industrial cost per kilogram approximately 20 times lower than that of the other CD types [104].…”

Section: Cyclodextrinsmentioning

confidence: 99%

“…Szente and Szejtli [104] studied the toxicity of CDs and demonstrated that oral administration of high doses of CDs does not cause any harm. Several studies have shown that CDs are nontoxic and do not present intoxication risks, because they are not absorbed in the gastrointestinal tract or through lipophilic biological membranes, and the same results have been obtained with regard to teratogenicity and mutagenicity [124][125][126][127][128].…”

Section: Cyclodextrinsmentioning

confidence: 99%

β-Cyclodextrins as Encapsulating Agents of Essential Oils

Capelezzo¹,

Mohr²,

Dalcanton³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Many scientific studies have made advances in the ability to encapsulate natural extracts by cyclodextrins. These studies have addressed the physical and chemical conditions of the encapsulation reactions, employed several types of essential oils and characterized the microcapsules as to their ability to release encapsulated active principles. The essential oils studies with cyclodextrin encapsulation processes have been highly varied. However, the most studied are the essential oils with antimicrobial and antioxidant capacities. The essential antimicrobial and antioxidant oils are easily degraded. In the presence of oxygen, they are oxidized, and at low temperatures, they are volatilized and decomposed. Thus, cyclodextrins are coatings capable of protecting these essential oils from environmental conditions and agents capable of promoting oil degradation, in addition to controlling their release. In this chapter of the book, we review scientific papers that examine the encapsulation of antimicrobial essential oils and antioxidant essential oils with β-cyclodextrins.

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“…The most known and studied members of this family are α-CD, β-CD and γ-CD which can complex a broad array of organic molecules through host-guest inclusion systems. CDs are widely used in various fields such as food technology, pharmaceutical, cosmetics and textile industry, [7][8][9][10][11][12][13] their cone-shaped structures enclose a hydrophilic external surface and a relatively hydrophobic inner cavity, resulting in the ability of CDs to encapsulate small hydrophobic organic guest molecules.…”

Section: Introductionmentioning

confidence: 99%