Cyclodextrin modified hydrogels of PVP/PEG for sustained drug release

Abstract

Hydrogels are water swollen networks of polymers and especially hydrogels consisting of poly vinylpyrrolidone/poly ethyleneglycol-dimethacrylate (PVP/PEG-DMA) blends show promising wound care properties. Enhanced functionality of the hydrogels can be achieved by incorporating drugs and other substances that may assist wound healing into the gel matrix. Controlling the release of active compounds from the hydrogels may be possible by carefully modifying the polymer matrix. For this purpose, cyclodextrins (CD) were grafted to the polymer matrix in 4-5 w/w% in an attempt to retard the release of water-soluble drugs. Ibuprofenate (IBU) was chosen as model drug and loaded in IBU/CD ratios of 0.6, 1.2, and 2.5. Vinyl derivatives of α-, β-and γ-CD were produced, added to the prepolymer blend and cured by UV-light. During this curing process the CD derivatives were covalently incorporated into the hydrogel matrix. The modified hydrogels were loaded with ibuprofenate by swelling. The release of the model drug from CD modified hydrogels show that especially covalently bonded β-cyclodextrin can change both the release rate and the release profile of ibuprofen.

Cyclodextrin-polyhydrazine degradable gels for hydrophobic drug delivery

“…The release rate of the drug was essentially limited by its solubility and continued for two weeks without showing an initial burst effect [28]. [29]. However, the preparation of in-situ forming hydrogels which are biodegradable and biocompatible to deliver hydrophobic drugs over an extended period is still needed.…”

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

“…Covalently bound hydrogel networks based on CD have been prepared via many methods, including the use of di‐functional cross‐linkers (e.g., diisocyanates), covalent linking of CD derivatives with functional polymers, and through the copolymerization of appropriate monomers with vinylic and acryloyl‐functionalized CD. By using these approaches, networks have been obtained that can be applied to a wide range of applications, including separation and absorption technologies (i.e., chiral separation and absorption of heavy metal ions for pollutant capture and removal, respectively), materials science, soft contact lenses, and sustained drug delivery systems . This section gives a general overview of the progress of the respective fields by focusing primarily on recent examples in the literature.…”

“…By using these approaches, networks have been obtained that can be applied to a wide range of applications, including separation and absorption technologies (i.e., chiral separation and absorption of heavy metal ions for pollutant capture and removal, respectively), [ 1,45,46 ] materials science, [ 47 ] soft contact lenses, [ 48,49 ] and sustained drug delivery systems. [50][51][52][53][54][55][56] This section gives a general overview of the progress of the respective fi elds by focusing primarily on recent examples in the literature.…”

Hydrogelexpander als Medikamentenabgabe-System für Antibiotika

“…Publizierte augenärztlich motivierte pharmakologische Untersuchungen beziehen sich hauptsächlich auf die Medikamentenabgabe aus Kontaktlinsen. Untersucht sind beispielsweise die Speicherung und Freisetzung von: β-Blockern [10,11], Kortisonpräparaten [11], Polymyxin [12] und Ibuprofen [13]. Mechanismen, die für die Aufnahme, Speicherung und Freigabe eine Rolle spielen, umfassen Diffusion des Pharmakons, Beeinflussung der Schwellungsfähigkeit der Hydrogelmatrix und mögliche chemische Reaktion des Pharmakons mit der Speichermatrix [13].…”

“…Untersucht sind beispielsweise die Speicherung und Freisetzung von: β-Blockern [10,11], Kortisonpräparaten [11], Polymyxin [12] und Ibuprofen [13]. Mechanismen, die für die Aufnahme, Speicherung und Freigabe eine Rolle spielen, umfassen Diffusion des Pharmakons, Beeinflussung der Schwellungsfähigkeit der Hydrogelmatrix und mögliche chemische Reaktion des Pharmakons mit der Speichermatrix [13]. Hydrogelkontaktlinsen können, bedingt durch ihren hohen Wassergehalt und die hohe intermolekulare Porengröße, wasserlösliche Pharmaka aufnehmen und wieder freisetzen [7,14].…”