Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Abstract

A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic estrogen hormone used as contraceptive, from water was tested. The yarns were prepared by spinning a deep eutectic solution (DES) of cellulose in choline chloride-urea. Despite their high porosity and water sorption capacity (5 g/g), the spun fiber yarns displayed high wet strength, up to 60% of that recorded in dry condition (128 MPa with 17% strain at break). Cyclodextrin irreversible attachment on the yarns was achieved with adsorbed chitosan and the conjugation reactions and capture of EE2 by the cyclodextrin-modified cellulose were confirmed via online detection with Surface Plasmon Resonance (SPR). The facile synthesis of the bioactive yarns and EE2 binding capacity from aqueous matrices (as high as 2.5 mg/g) indicate excellent prospects for inexpensive platforms in disposable affinity filtration. The study presents a strategy to produce a wood fiber based yarn to be used as a platform for human and veterinary pharmaceutical hormone capture.

Absorbent Filaments from Cellulose Nanofibril Hydrogels through Continuous Coaxial Wet Spinning

“…Furthermore, these filaments absorb significantly more water than a fiber yarn spun from macroscopic cellulose fibers (5 g/g), 16 or even fluff pulp (12 g/g), 48 which is a typical component in commercial absorbent products. This highlights the benefits of the increased surface area by disintegration of wood fibers to the nanoscale.…”

Polymer Science and Engineering Using Deep Eutectic Solvents

“…Following this new development, Wang et al and Mendonça et al published the first studies on the use of different DES as ligand [77], as 100% solvent for SARA ATPR [78] or both [77]. Other studies also reported the use of DES as solvent medium for polymer synthesis [46,79,80,81,82,83,84,85,86,87,88,89,90]. In particular, the communication of Park and Lee on the polymerization of 3-octylthiophene in DES presented interesting features regarding the use of DES as a solvent in polymerization.…”

Spinning Approach for Cellulose Fiber Yarn Using a Deep Eutectic Solvent and an Inclined Channel

“…Given the range of attainable properties, the yarns can be further developed in an application-oriented approach. For example, Orelma et al 43 produced fiber yarns with a similar process. The open inner structure and good water absorption capability of the fiber yarns enabled their use in cyclodextrin-based capture of synthetic estrogen hormones from water.…”