Cyclodextrin functionalization of several cellulosic substrates for prolonged release of antibacterial agents

Abstract

Several cellulosic substrates have been surface-functionalized with cyclomaltoheptaose (b-cyclodextrin, b-CD) using citric acid as a crosslinker agent to obtain new surface-modified materials able to release antiseptic molecules over a prolonged period, in view of their use in medical domain. Three different commercial cellulosic substrates were used, namely: (i) an uncoated paper, (ii) a crepe paper, and (iii) a medical bandage. They were successfully grafted by a crosslinked polymer consisting on b-CD molecules as assessed by scanning electron microscopy and Fourier transform infrared spectroscopy analysis. Several time–temperature kinetic cycles were performed to reach the optimum curing parameters. The grafted and nongrafted samples were loaded with chlorhexidine digluconate (digCHX), a widely used antiseptic agent. The drug-delivery kinetics of the encapsulated digCHX was carried out by immersing the sample under investigation into an aqueous medium, and the quantity of the released digCHX was measured, as a function of time, by UV spectroscopy. The optimal grafting conditions were established on the basis of the highest weight gain. These samples did not give the best release performance. Nevertheless, several grafted substrates were able to uptake an appreciable amount of active molecules and release them over a prolonged time of about 20 daysPostprint (published version

Screening Fungal Endophytes Derived from Under-Explored Egyptian Marine Habitats for Antimicrobial and Antioxidant Properties in Factionalised Textiles

“…On the other hand, the efficacy of the imparted antimicrobial activity, expressed as the size of inhibition zone, against the targeted microorganisms was determined by the type of target microorganism, e.g., bacteria or fungi, their cell wall structure, their amenability to damage, and their capability to inactivate bioactive ingredients present in the bioactive extracts tested. The encapsulated bioactive extracts had practically no (in the case of M113 or 7S4) or only moderate inhibitory effects (as in the case of 13A) against the E. coli strain [ 38 , 39 , 40 , 41 , 42 ].…”

β-Cyclodextrin Grafted Cellulose and Cationic Starch for Antibacterial Paper Products: A Comparative Study

“…Cationic starch, a chemically modified starch, is widely used as an additive, for example in papermaking to improve mechanical strength, retention of fines, dyes, and fillers, faster drainage, runability of the paper machine, and to decrease biological oxygen demand of paper mill effluent (Kuo and Lai 2007). To combine the advantages of both CDs and polysaccharides, the CD grafted polysaccharides, such as cellulose and cationic starch, have gained interest because they can be widely used in various fields (Buschmann et al 1998;Gao and Zhao 2004;Martel et al 2002;Ozmen and Yilmaz 2007;Xiao et al 2007;Grigoriu et al 2011;Cusola et al 2013). Therefore, the introduction of CD moieties into the polysaccharide backbone may lead to a molecular carrier that possesses the cumulative effects of inclusion, size specificity, and transport properties of CDs as well as the biocompatible and renewable properties of the polymeric matrix.…”

Polymers for biomedical applications

“…This can include polymeric particles specifically targeted for release in specific conditions, such as the pH-sensitive carriers shown by Kong and coworkers, 1 or thermal-sensitive carriers as shown by Teixeira et al 2 Tissue engineering scaffolds are another area in which polymeric materials are widely employed, as in the work by Vozzi et al 3 Electrospun polymeric nanofibers also come in handy when designing vascular prostheses, as shown by Mazalevska et al 4 At the same time, topical applications such as wound dressings are feasible and they have generated an enormous body of literature, especially with respect to textiles and nonwoven fibrous materials. This is shown in the work of McCord and coworker 5 about nanofiber wound dressings, as well as in the article by Cusola et al 6 exemplifying long-term release of antibacterials.…”