Cyclodextrin-containing poly(ethyleneoxide) tablets for the delivery of poorly soluble drugs: Potential as buccal delivery system

Cappello, B; Rosa, Giuseppe De; Giannini, Lucia; Rotonda, Maria Immacolata La; Mensitieri, Giuseppe; Miro, Agnese; Quaglia, Fabiana; Russo, R.

doi:10.1016/j.ijpharm.2006.03.031

Cited by 47 publications

(15 citation statements)

References 20 publications

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“…20 The hydrophobic cavity in CDs can partially accommodate low molecular lipophilic drug molecule and polymers. 21 Hydrophilic drug-CD complexes are formed by inclusion of lipophilic drug or lipophilic drug molecule in the central cavity. The lipophilic cavity thus protects the lipophilic guest molecule from aqueous environment, while the outer polar surface of the CD provides the solubilizing effect.…”

Section: Structure Of Cdsmentioning

confidence: 99%

“…Cappello et al 21 prepared tablet for the buccal delivery of the poorly soluble drug carvedilol containing poly (ethyleneoxide) as bioadhesive material for sustained-release and hydroxypropyl-β-cyclodextrin as modulator for enhancing drug release. The results confirmed that the prepared hydroxypropyl-β-cyclodextrin containing tablets showed increase in drug dissolution.…”

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

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Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Maheriya¹

2017

MOJBB

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Most of the drugs administered through oral route have poor aqueous solubility and dissolution rate. Cyclodextrin and its derivates represent as pharmaceutical adjuvants to overcome this challenges and helps in development of stable formulation with enhanced bioavailability. Cyclodextrins are unique structure with versatile physicochemical properties which aids the pharmaceutical scientists to overcome drug delivery challenges for poorly aqueous soluble drugs. Cyclodextrin and its derivates are widely useful as solubilizers, assisting in preparation of various dosage forms such as liquid oral, solid, and parenteral preparations. Cyclodextrins interacts with appropriately sized guest molecules to form inclusion complex and enhance the aqueous solubility, physical chemical stability, and bioavailability of drugs. Through the various reported literatures, the review highlights the concept of cyclodextrin and its derivatives in enhancing solubility and bioavailability of poorly aqueous soluble drugs.

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Section: Structure Of Cdsmentioning

confidence: 99%

Section: Figure 1 Depicts the Guest-host Inclusion Complexes Formationmentioning

confidence: 99%

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Maheriya¹

2017

MOJBB

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“…It has been shown that carvedilol forms 1:2 drug/cyclodextrin complexes with the natural β-cyclodextrin (βCD; 3). 2-Hydroxypropyl-βCD (HPβCD) and sulfobutylether βCD (SBEβCD) have been used as complexing agent in carvedilol buccal and sustained release tablets (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

et al. 2008

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“…PEO have recently received wide attention as sustained-release bioadhesive platform due to its safety, ease of processing and possibility to control drug release. In medicine, the polymer has been incorporated in several drugs such as oral sustainedrelease tablets [1][2][3][4][5] and ocular inserts. 6 in addition, it has been shown that particles with poly(ethylene oxide) surfaces have great potential as long circulating systems after intravenous administration [7][8][9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Solvent-Free Synthesis of New Bis(Benzimidazole-2-Alkylthio) Polyethylene Oxides Starting from Dithiols

Akremi¹,

Noubigh²

2017

Orient. J. Chem

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Polyethylene oxide (PEO) could be incorporated in molecular structure by several ways. A series of diacid S-alkylpolyethylene oxides 4a-i have been prepared from dithiols 1a-c through multistep reaction sequence. Novel symmetric bis-benzimidazoles (polyethylene oxide) 6a-i have been synthesized over green route. The condensation of the title compounds 4a-i on o-phenylenediamine 5, via the further deamination reaction and without catalyst, afforded the corresponding bisbenzimidazoles 6a-i in acceptable yields. The new compounds were established on the basis of their elemental analysis, IR, 1 H NMR, 13C NMR and mass spectral data.

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Cyclodextrin-containing poly(ethyleneoxide) tablets for the delivery of poorly soluble drugs: Potential as buccal delivery system

Cited by 47 publications

References 20 publications

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Cyclodextrin: A Promising Candidate in Enhancing Oral Bioavailability of poorly Water Soluble Drugs

Carvedilol: Solubilization and Cyclodextrin Complexation: A Technical Note

Solvent-Free Synthesis of New Bis(Benzimidazole-2-Alkylthio) Polyethylene Oxides Starting from Dithiols

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