Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release

Xu, Jinku; Li, Xinsong; Sun, Fang

doi:10.1016/j.actbio.2009.07.021

Cited by 153 publications

(80 citation statements)

References 28 publications

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“…Even the ingenious approaches (e.g. molecular functionalisation, molecular imprinting, drug encapsulation, use of carriers and incorporation of diffusion barriers 35,[50][51][52][53][54] ) that have been currently envisaged as methods of producing enhanced control of drug delivery from the lens ultimately involve diffusion of drug through the lens material. It is therefore essential to understand the factors related to partition and diffusional release in order to design effective systems.…”

Section: Resultsmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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The poor retention and efficacy of instilled drops as a means of delivering drugs to the ophthalmic environment is well-recognised. The potential value of contact lenses as a means of ophthalmic drug delivery and consequent improvement of pre-corneal retention is one obvious route to the development of a more effective ocular delivery system. Furthermore, the increasing availability and clinical use of daily disposable contact lenses provides the platform for the development of viable single-day use drug delivery devices based on existing materials and lenses. In order to provide a basis for the effective design of such devices, a systematic understanding of the factors affecting the interaction of individual drugs with the lens matrix is required. Because a large number of potential structural variables are involved it is necessary to achieve some rationalisation of the parameters and physicochemical properties (such as molecular weight, charge, partition coefficients) that influence drug interactions. Ophthalmic dyes and structurally related compounds based on the same core structure were used to investigate these various factors and the way in which they can be used in concert to design effective release systems for structurally different drugs. Initial studies of passive diffusional release form a necessary precursor to the investigation of the features of the ocular environment that over-ride this simple behaviour. Commercially available contact lenses of differing structural classifications were used to study factors affecting the uptake of the surrogate actives and their release under "passive" conditions. The interaction between active and lens material shows considerable and complex structure dependence which is not simply related to equilibrium water content (EWC). The structure of the polymer matrix itself was found to have the dominant controlling influence on active uptake; hydrophobic interaction with the ophthalmic dye playing a major role.3

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Section: Resultsmentioning

confidence: 99%

The design of contact lens based ocular drug delivery systems for single-day use: Part (I) Structural factors, surrogate ophthalmic dyes and passive diffusion studies

Mahomed

Tighe

2014

J Biomater Appl

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“…Furthermore, the microbiological test showed better antimicrobial activity for complexcoated vascular prostheses, and also showed that a wide range of antibiotics can be included into CDs, which makes them potential for the treatment of multigerm vascular prostheses infections. 56,60,61 Not only are CDs used alone as a carrier, but they are also incorporated into other carriers, such as bioactive glasses 62 and polymers, 63 to obtain an extended release.…”

Section: Antibiotic Materials Extended-release Dds P Gao Et Almentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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“…51 The role of cyclodextrins has also been commented in other studies. 52 To enhance the potential of pHEMA hydrogels as an effective biomaterial for contact lens-based ophthalmic drug delivery system, 4-vinylpyridine (VP) and N-(3-aminopropyl)methacrylamide (APMA) were incorporated into the network and prolonged drug delivery was seen.…”

mentioning

confidence: 97%