Cyclodextrin-based nanostructures

Narayanan, Ganesh; Shen, Jialong; Matai, Ishita; Sachdev, Abhay; Boy, Ramiz; Tonelli, Alan E.

doi:10.1016/j.pmatsci.2021.100869

Cited by 62 publications

(38 citation statements)

References 416 publications

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“…In this context, cyclodextrins can adopt a variety of nanometric forms beside their intrinsic ability to act as capping or reducing agents for metallic nanoparticles. CDs can also form stable nanoparticles/fibers or nanomicelles, which can be subsequently utilized for plenty of applications, including active food packaging [ 138 ]. An interesting work in this regard has been reported by Lin et al, who detailed different nanoencapsulation strategies for natural compounds based on liposomes and chitosan nanogels [ 139 ].…”

Section: Methods Of Incorporating Cds In Polymer-based Active Food Packagingmentioning

confidence: 99%

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

et al. 2021

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Using cyclodextrins (CDs) in packaging technologies helps volatile or bioactive molecules improve their solubility, to guarantee the homogeneous distribution of the complexed molecules, protecting them from volatilization, oxidation, and temperature fluctuations when they are associated with polymeric matrices. This technology is also suitable for the controlled release of active substances and allows the exploration of their association with biodegradable polymer targeting to reduce the negative environmental impacts of food packaging. Here, we present a fresh look at the current status of and future prospects regarding the different strategies used to associate cyclodextrins and their derivatives with polymeric matrices to fabricate sustainable and biodegradable active food packaging (AFP). Particular attention is paid to the materials and the fabrication technologies available to date. In addition, the use of cutting-edge strategies, including the trend of nanotechnologies in active food packaging, is emphasized. Furthermore, a critical view on the risks to human health and the associated updated legislation is provided. Some of the more representative patents and commercial products that currently use AFP are also listed. Finally, the current and future research challenges which must be addressed are discussed.

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Section: Methods Of Incorporating Cds In Polymer-based Active Food Packagingmentioning

confidence: 99%

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

et al. 2021

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“…Several colloidal delivery systems such as micro- and nanoemulsions [ 52 ], liposomes [ 53 , 54 , 55 ], solid lipid nanoparticles (SLNPs) [ 56 , 57 ], nanostructured lipid carriers (NLCs) [ 58 , 59 , 60 ], liquid crystalline NPs [ 61 ], biopolymer microgels [ 62 ], nanocapsules [ 63 ], cyclodextrins (CDs) [ 64 , 65 , 66 , 67 ], smart responsive materials polymer-based NPs [ 68 , 69 , 70 , 71 ] or dendrimers [ 72 , 73 ] can be used for encapsulation of pharmacologically active compounds. By internalization of drugs to nanocarriers (NCs) their stability, bioavailability, cellular uptake/internalization, and pharmacokinetic profile can be ameliorated along with the reduction of their toxicity [ 42 , 74 , 75 , 76 ].…”

Section: Nanosystems and Their Benefitsmentioning

confidence: 99%

“…These inorganic carriers are usually functionalized with the above-mentioned organic polymers, resulting in hybrid NCs, in which active molecules are trapped. Depending on the used material, different NCs are formed, such as liposomes/lipid-based delivery systems, polymeric NPs (micelles, spheres, capsules), dendrimers, polymeric complex NPs, CDs, nanocrystals, electrospun nanofibers, electro-sprayed NPs, nano-spray dried particles, covalent organic frameworks, hydrogels, inorganic nanosystems (quantum dots, carbon based NPs) [ 41 , 45 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 117 , 118 , 119 , 120 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 143 ]. Table 1 provides an overview of the types of nanoformulations discussed and their basic building blocks, while Figure 2 , Figure 3 , Figure 4 and Figure 5 illustrate the individual anti-infective drugs listed in this review.…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Nanostructures for Antimicrobial Therapy

Jampílek

Kráľová

2022

Materials

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Microbial infections caused by a variety of drug-resistant microorganisms are more common, but there are fewer and fewer approved new antimicrobial chemotherapeutics for systemic administration capable of acting against these resistant infectious pathogens. Formulation innovations of existing drugs are gaining prominence, while the application of nanotechnologies is a useful alternative for improving/increasing the effect of existing antimicrobial drugs. Nanomaterials represent one of the possible strategies to address this unfortunate situation. This review aims to summarize the most current results of nanoformulations of antibiotics and antibacterial active nanomaterials. Nanoformulations of antimicrobial peptides, synergistic combinations of antimicrobial-active agents with nitric oxide donors or combinations of small organic molecules or polymers with metals, metal oxides or metalloids are discussed as well. The mechanisms of actions of selected nanoformulations, including systems with magnetic, photothermal or photodynamic effects, are briefly described.

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“…In spite of α-,β-,δ-CDs being the most common CDs, a variety of CD derivatives have been developed with the objective of enhancing the physicochemical properties of natural CDs. For example, to increase the water solubility of β-CD (1.85% w / v , T = 25 °C [ 19 ], chemically modified β-CDs (hydroxypropyl (HP), randomly methylated (RM) β-CDs with aqueous solubilities > 600% w / v and >500, respectively, T = 25 °C [ 166 ] have been synthesized and widely used in the pharmaceutical and food industries. Due to their physical characteristics and chemical stability, (CDs) are widely employed as carrier systems to deliver the needed amount of bio-active compound to the targeted site for the necessary period of time [ 166 , 167 , 168 ].…”

Section: Some Common Delivery Systemsmentioning

confidence: 99%

Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena

et al. 2021

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Toxicity caused by the exposure to human-made chemicals and environmental conditions has become a major health concern because they may significantly increase the formation of reactive oxygen species (ROS), negatively affecting the endogenous antioxidant defense. Living systems have evolved complex antioxidant mechanisms to protect cells from oxidative conditions. Although oxidative stress contributes to various pathologies, the intake of molecules such as polyphenols, obtained from natural sources, may limit their effects because of their antioxidant and antimicrobial properties against lipid peroxidation and against a broad range of foodborne pathogens. Ingestion of polyphenol-rich foods, such as fruits and vegetables, help to reduce the harmful effects of ROS, but the use of supramolecular and nanomaterials as delivery systems has emerged as an efficient method to improve their pharmacological and therapeutic effects. Suitable exogenous polyphenolic antioxidants should be readily absorbed and delivered to sites where pathological oxidative damage may take place, for instance, intracellular locations. Many potential antioxidants have a poor bioavailability, but they can be encapsulated to improve their ideal solubility and permeability profile. Development of effective antioxidant strategies requires the creation of new nanoscale drug delivery systems to significantly reduce oxidative stress. In this review we provide an overview of the oxidative stress process, highlight some properties of ROS, and discuss the role of natural polyphenols as bioactives in controlling the overproduction of ROS and bacterial and fungal growth, paying special attention to their encapsulation in suitable delivery systems and to their location in colloidal systems where interfaces play a crucial role.

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Cyclodextrin-based nanostructures

Cited by 62 publications

References 416 publications

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

Cyclodextrins in Polymer-Based Active Food Packaging: A Fresh Look at Nontoxic, Biodegradable, and Sustainable Technology Trends

Advances in Nanostructures for Antimicrobial Therapy

Polyphenols as Antioxidants for Extending Food Shelf-Life and in the Prevention of Health Diseases: Encapsulation and Interfacial Phenomena

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