Abstract:Recently, active pharmaceutical ingredients (APIs) have been dramatically expanding from low-molecular weight drugs to peptides, proteins, antibodies, genes, oligonucleotides, cells, and machines. Therefore to develop pharmaceutical technologies and drug delivery systems (DDS) for these APIs, advanced molecules and novel concepts are needed. In this review, we introduce cyclodextrin-based supramolecular accessories such as molecular necklace, molecular earring, and intelligent molecular necklace, and describe … Show more
“…Cyclodextrins are still regarded as "novel" excipients, active ingredients, drug delivery vehicles and anti-aggregation agents (Conceição et al 2018). New formulations continue to be reported, generating new interests in medicine and biomedicine (Higashi et al 2018;Higashi 2019;Menezes et al 2019;Pawar and Shende 2019). The 18 ongoing clinical trials in 2019 give the promise of new marketed formulations (Cyclodextrin News, CycloLab Ltd., Hungary).…”
Section: Cyclodextrins: Trends and Outlookmentioning
Cyclodextrins are a group of cyclic oligosaccharides obtained by enzymatic degradation of starch. They are remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health science, and agriculture. Their molecular structure is composed of a hydrophobic cavity that can encapsulate other compounds to form inclusion complexes through host-guest interactions. This unique feature is at the origin of many applications. Cyclodextrins and their derivatives have a wide variety of practical applications in almost all sectors of the industry, including pharmacy, medicine, foods, cosmetics, chromatography, catalysis, biotechnology, and the textile industry. Villiers published the first reference to cyclodextrins in 1891, and since then, these molecules have continued to fascinate academia and industry. Currently, more than 2000 publications on cyclodextrins are published each year. On the occasion of the 130th anniversary of their discovery, in this review, we present an historical overview of the development and applications of cyclodextrins. First, we present the discovery and first chemical studies on cyclodextrins. Then, the main results obtained during the 1911-1970 exploration period are discussed. A third part presents the historical landmarks in the development of cyclodextrins from 1970 to the present day.
“…Cyclodextrins are still regarded as "novel" excipients, active ingredients, drug delivery vehicles and anti-aggregation agents (Conceição et al 2018). New formulations continue to be reported, generating new interests in medicine and biomedicine (Higashi et al 2018;Higashi 2019;Menezes et al 2019;Pawar and Shende 2019). The 18 ongoing clinical trials in 2019 give the promise of new marketed formulations (Cyclodextrin News, CycloLab Ltd., Hungary).…”
Section: Cyclodextrins: Trends and Outlookmentioning
Cyclodextrins are a group of cyclic oligosaccharides obtained by enzymatic degradation of starch. They are remarkable macrocyclic molecules that have led major theoretical and practical advances in chemistry, biology, biochemistry, health science, and agriculture. Their molecular structure is composed of a hydrophobic cavity that can encapsulate other compounds to form inclusion complexes through host-guest interactions. This unique feature is at the origin of many applications. Cyclodextrins and their derivatives have a wide variety of practical applications in almost all sectors of the industry, including pharmacy, medicine, foods, cosmetics, chromatography, catalysis, biotechnology, and the textile industry. Villiers published the first reference to cyclodextrins in 1891, and since then, these molecules have continued to fascinate academia and industry. Currently, more than 2000 publications on cyclodextrins are published each year. On the occasion of the 130th anniversary of their discovery, in this review, we present an historical overview of the development and applications of cyclodextrins. First, we present the discovery and first chemical studies on cyclodextrins. Then, the main results obtained during the 1911-1970 exploration period are discussed. A third part presents the historical landmarks in the development of cyclodextrins from 1970 to the present day.
“…Cyclodextrins (CD, Figure 2), cyclic oligosaccharides derived from starch, are the most popular and developed drug delivery systems [22,23]. CDs have a hydrophilic shell and hydrophobic core suitable for the inclusion of lipophilic “guest” molecules of appropriate size.…”
Carotenoids are natural dyes and antioxidants widely used in food processing and in therapeutic formulations. However, their practical application is restricted by their high sensitivity to external factors such as heat, light, oxygen, metal ions and processing conditions, as well as by extremely low water solubility. Various approaches have been developed to overcome these problems. In particular, it was demonstrated that application of supramolecular complexes of “host-guest” type with water-soluble nanoparticles allows minimizing the abovementioned disadvantages. From this point of view, nanoencapsulation of carotenoids is an effective strategy to improve their stability during storage and food processing. Also, nanoencapsulation enhances bioavailability of carotenoids via modulating their release kinetics from the delivery system, influencing the solubility and absorption. In the present paper, we present the state of the art of carotenoid nanoencapsulation and summarize the data obtained during last five years on preparation, analysis and reactivity of carotenoids encapsulated into various nanoparticles. The possible mechanisms of carotenoids bioavailability enhancement by multifunctional delivery systems are also discussed.
“…Recent findings have also suggested that polypseudorotaxane hydrogels consisting of α- or γ-CD and PEG (mw 20,000 Da) markedly improved stabilities of human IgG against heating and shaking ( Higashi et al, 2015 ), suggesting them as stabilizers for antibody drugs without changing their pharmacokinetics ( Fig. 4 B) ( Higashi, 2019 ). Fig.…”
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